questionsmedicales.fr
Facteurs biologiques
Protéines et peptides de signalisation intercellulaire
Cytokines
Chimiokines
Chimiokines CXC
Chimiokines CXC : Questions médicales fréquentes
Termes MeSH sélectionnés :
Matrix Metalloproteinase 3
Diagnostic
5
Chimiokines
Tests de laboratoire
Maladies auto-immunes
Inflammation
Biopsie
Immunohistochimie
Symptômes
5
Système nerveux
Inflammation cérébrale
Psoriasis
Maladies cutanées
Maladies inflammatoires de l'intestin
Symptômes digestifs
Prévention
5
Hygiène de vie
Gestion du stress
Alimentation
Antioxydants
Exercice physique
Santé immunitaire
Stress chronique
Inflammation
Traitements
5
Thérapies biologiques
Inhibiteurs
Corticostéroïdes
Inflammation
Traitements anti-inflammatoires
Symptômes inflammatoires
Essais cliniques
Traitements
Complications
5
Maladies auto-immunes
Infections chroniques
Cicatrisation
Inflammation
Maladies cardiovasculaires
Risque
Sclérose en plaques
Alzheimer
Facteurs de risque
5
Infections
Expression génique
Vieillissement
Inflammation
Diabète
Maladies métaboliques
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"name": "Comment diagnostiquer une dysrégulation des chimiokines CXC ?",
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"text": "Des tests sanguins et des analyses de cytokines peuvent aider à évaluer les niveaux de chimiokines."
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"@type": "Question",
"name": "Quels tests sont utilisés pour mesurer les chimiokines CXC ?",
"position": 2,
"acceptedAnswer": {
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"text": "Les dosages ELISA et les tests multiplex sont couramment utilisés pour mesurer les chimiokines."
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"@type": "Question",
"name": "Les chimiokines CXC sont-elles liées à des maladies spécifiques ?",
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"@type": "Question",
"name": "Peut-on détecter les chimiokines CXC dans les biopsies ?",
"position": 4,
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"@type": "Answer",
"text": "Oui, les chimiokines peuvent être détectées dans les tissus par immunohistochimie."
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"name": "Les niveaux de chimiokines CXC varient-ils selon l'âge ?",
"position": 5,
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"text": "Oui, les niveaux de chimiokines peuvent varier avec l'âge et l'état de santé général."
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"@type": "Question",
"name": "Quels symptômes sont associés à une surproduction de chimiokines CXC ?",
"position": 6,
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}
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"@type": "Question",
"name": "Les chimiokines CXC peuvent-elles causer des symptômes respiratoires ?",
"position": 7,
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"text": "Oui, elles sont impliquées dans des maladies respiratoires comme l'asthme et la BPCO."
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"@type": "Question",
"name": "Comment les chimiokines CXC affectent-elles le système nerveux ?",
"position": 8,
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"text": "Elles peuvent contribuer à des troubles neurologiques en modulant l'inflammation cérébrale."
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"@type": "Question",
"name": "Les chimiokines CXC sont-elles liées à des symptômes cutanés ?",
"position": 9,
"acceptedAnswer": {
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"text": "Oui, elles peuvent être impliquées dans des maladies cutanées inflammatoires comme le psoriasis."
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"@type": "Question",
"name": "Peut-on observer des symptômes digestifs liés aux chimiokines CXC ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent jouer un rôle dans des maladies inflammatoires de l'intestin."
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"@type": "Question",
"name": "Peut-on prévenir les maladies liées aux chimiokines CXC ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une bonne hygiène de vie et la gestion du stress peuvent aider à prévenir certaines maladies."
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"@type": "Question",
"name": "L'alimentation influence-t-elle les chimiokines CXC ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en antioxydants peut réduire l'inflammation et les chimiokines."
}
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"@type": "Question",
"name": "L'exercice physique affecte-t-il les niveaux de chimiokines CXC ?",
"position": 13,
"acceptedAnswer": {
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"text": "Oui, l'exercice régulier peut moduler les niveaux de chimiokines et améliorer la santé immunitaire."
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"@type": "Question",
"name": "Le tabagisme influence-t-il les chimiokines CXC ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme augmente les niveaux de chimiokines et contribue à l'inflammation."
}
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"@type": "Question",
"name": "Le stress chronique affecte-t-il les chimiokines CXC ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut augmenter l'expression des chimiokines et aggraver l'inflammation."
}
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"@type": "Question",
"name": "Quels traitements ciblent les chimiokines CXC ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies biologiques et des inhibiteurs de chimiokines sont en développement."
}
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"@type": "Question",
"name": "Les corticostéroïdes affectent-ils les chimiokines CXC ?",
"position": 17,
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"@type": "Question",
"name": "Comment les inhibiteurs de chimiokines CXC fonctionnent-ils ?",
"position": 18,
"acceptedAnswer": {
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"text": "Ils bloquent les récepteurs des chimiokines, réduisant ainsi l'inflammation et la migration cellulaire."
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"@type": "Question",
"name": "Les traitements anti-inflammatoires influencent-ils les chimiokines CXC ?",
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"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des maladies auto-immunes, des infections chroniques et des cancers."
}
},
{
"@type": "Question",
"name": "Les chimiokines CXC sont-elles impliquées dans le cancer ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent favoriser la progression tumorale et la métastase dans certains cancers."
}
},
{
"@type": "Question",
"name": "Comment les chimiokines CXC affectent-elles la cicatrisation des plaies ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surproduction peut retarder la cicatrisation en exacerbant l'inflammation."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles liées aux chimiokines CXC ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux élevés de chimiokines sont associés à un risque accru de maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les chimiokines CXC peuvent-elles causer des troubles neurologiques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont impliquées dans des troubles comme la sclérose en plaques et l'Alzheimer."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque augmentent les niveaux de chimiokines CXC ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité, le tabagisme et le stress chronique sont des facteurs de risque connus."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles influencer les chimiokines CXC ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les infections aiguës et chroniques peuvent augmenter l'expression des chimiokines."
}
},
{
"@type": "Question",
"name": "L'exposition à des polluants affecte-t-elle les chimiokines CXC ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des polluants environnementaux peut augmenter les niveaux de chimiokines."
}
},
{
"@type": "Question",
"name": "Le vieillissement influence-t-il les chimiokines CXC ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut entraîner une augmentation des niveaux de chimiokines et de l'inflammation."
}
},
{
"@type": "Question",
"name": "Les maladies métaboliques sont-elles liées aux chimiokines CXC ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le diabète peuvent augmenter les niveaux de chimiokines et l'inflammation."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
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To develop a highly sensitive time-resolved fluorescence immunoassay (TRFIA) for the detection of serum matrix metalloproteinase-3 (MMP-3) and to assess MMP-3's clinical value in patients with colorec...
MMP-3 levels were established using the double antibody sandwich technique. The MMP-3 TRFIA technique was developed and optimized, and its linearity, sensitivity, accuracy, specificity, and recovery w...
The linear range of MMP-3 TRFIA was 0.73-500 ng/mL. MMP-3 TRFIA had an intra-batch precision range of 2.16%-7.10% percent and an inter-batch precision range of 3.99%-11.21%. MMP-3, tumor-associated tr...
A highly sensitive MMP-3 TRFIA assay was successfully developed, and serum MMP-3 may be associated with CRC invasion and metastasis. Therefore, MMP-3 can be used in the auxiliary diagnosis of CRC....
Anti-citrullinated protein antibodies (ACPAs) are highly specific for the diagnosis of rheumatoid arthritis (RA). However, about one-third of RA patients are negative for ACPAs, which presents a chall...
A highly sensitive and selective electrogenerated chemiluminescence (ECL) biosensor was developed for the determination of matrix metalloproteinase 3 (MMP-3) in serum via the target-induced cleavage o...
Metalloproteinases-3 (MMP3) are the main enzymes involved in cartilage degradation. Several genetic and non-genetic factors can increase the expression of MMP3 in patients with osteoarthritis (OA). Th...
A cross-sectional study was conducted at the orthopedic polyclinic Arifin Achmad Riau Province and Ibn Sina Hospital in Pekanbaru City. Ninety women who experienced knee OA were taken as samples by co...
The MMP3 rs679620 gene polymorphism of the mutant type was 88.9%, with the same proportion of AG and GG alleles (44.4%). Subjects aged ≥ 60 years were 53.3%, 85.6% did not work and 84.4% had menopause...
Diabetic neuropathy and nephropathy are common complications of type 1 diabetes (T1D). The symptoms are often elusive in the early stages, and available diagnostic methods can be improved using biomar...
Matrix metalloproteinase-3 (MMP-3) is a proteolytic enzyme involved in acute respiratory distress syndrome (ARDS) pathophysiology that may serve as a lung-specific biomarker in ARDS....
This study was a secondary biomarker analysis of a subset of Albuterol for the Treatment of Acute Lung Injury (ALTA) trial patients to determine the prognostic value of MMP-3. Plasma sample MMP-3 was ...
A total of 100 unique patient samples were evaluated and the AUROC analysis of day three MMP-3 showed an AUROC of 0.77 for the prediction of 90-day mortality (95% confidence interval: 0.67-0.87), corr...
Day three MMP-3 concentration and difference in day zero and three MMP-3 concentrations demonstrated acceptable AUROCs for predicting 90-day mortality with a cut-point of 18.4 ng/mL and + 9.5 ng/mL, r...
Studies using salivary inflammatory biomarkers for diagnosing and monitoring the progression of periodontal disease have garnered increased attention in recent years. The present study aimed to identi...
A 6-week NSPT program was applied to 51 adults aged ≥ 20 years. The program involved scaling, root planing, and professional toothbrushing for healthy participants and those with periodontal disease. ...
All clinical parameters were improved in the periodontal disease groups following the NSPT course. Compared with healthy participants, the patients with periodontal disease showed increased concentrat...
The present study found that NSPT resulted in reductions of salivary MMP-3, -8, and -9, and identified the potential of MMP-3 as a biomarker in the diagnosis of periodontal disease. These findings may...
Matrix metalloproteinases (MMPs) are widely expressed in atherosclerosis lesions. The disequilibrium of MMPs driving to an overexpression or a lack of its level can be influenced by genetic variations...
A total of 168 patients with CAD were prospectively followed up over a period of 5 years. Genotypes for the MMP-3 (-1612 5 A/6A) and MMP-9 (-1562 C/T) polymorphisms were performed using PCR-RFLP. Thei...
Our study suggests the disruption of the MMP-3 level may be due to the existence of the polymorphism - 1612 residing in its promoter region. MMP-3 can be considered as a marker of diagnosis and predic...
Matrix metalloproteinases (MMPs) are involved in extracellular matrix remodeling through the degradation of extracellular matrix components and are also involved in the inflammatory response by regula...
Alzheimer's disease (AD) can be characterised in vivo by biomarkers reflecting amyloid-β (Aβ) and tau pathology. However, there is a need for biomarkers reflecting additional pathological pathways. Ma...
In this cross-sectional study, we investigated nine MMPs and four tissue inhibitors of metalloproteinases (TIMPs) in the cerebrospinal fluid of 256 memory clinic patients with mild cognitive impairmen...
MMP-10 and TIMP-2 levels differed significantly between the memory clinic patients and the cognitively unimpaired controls. Furthermore, MMP- and TIMP-levels were generally strongly associated with ta...
Our results support the use of MMPs/TIMPs as markers of sex differences and progression in AD. Our findings show sex-specific effects of MMP-3 and TIMP-4 on amyloid pathology. Further, this study high...
