Comment le milrinone est-il diagnostiqué pour l'insuffisance cardiaque ?
Le milrinone n'est pas un diagnostic, mais un traitement pour l'insuffisance cardiaque.
Insuffisance cardiaqueMilrinone
#2
Quels tests précèdent l'administration de milrinone ?
Des tests comme l'échocardiogramme et les analyses sanguines sont effectués.
ÉchocardiographieAnalyses sanguines
#3
Quand envisager le milrinone dans le diagnostic ?
Il est envisagé en cas d'insuffisance cardiaque sévère ou réfractaire aux autres traitements.
Insuffisance cardiaqueTraitement
#4
Le milrinone est-il utilisé pour le diagnostic précoce ?
Non, il est utilisé comme traitement, pas pour le diagnostic précoce.
DiagnosticMilrinone
#5
Quels signes cliniques indiquent l'utilisation de milrinone ?
Des signes comme la dyspnée et la fatigue peuvent indiquer son utilisation.
DyspnéeFatigue
Symptômes
5
#1
Quels symptômes le milrinone aide-t-il à soulager ?
Il aide à soulager les symptômes d'insuffisance cardiaque comme l'essoufflement.
EssoufflementInsuffisance cardiaque
#2
Le milrinone peut-il provoquer des effets secondaires ?
Oui, des effets comme des palpitations ou des maux de tête peuvent survenir.
Effets secondairesPalpitations
#3
Quels symptômes nécessitent une attention médicale avec milrinone ?
Des symptômes comme des douleurs thoraciques ou des éruptions cutanées doivent être signalés.
Douleurs thoraciquesÉruptions cutanées
#4
Le milrinone affecte-t-il la pression artérielle ?
Oui, il peut provoquer une hypotension, nécessitant une surveillance.
HypotensionSurveillance
#5
Quels symptômes indiquent une surdose de milrinone ?
Des symptômes comme des nausées, des vomissements ou des troubles de la vision peuvent indiquer une surdose.
SurdoseNausées
Prévention
5
#1
Comment prévenir l'insuffisance cardiaque ?
Maintenir un mode de vie sain, contrôler la pression artérielle et éviter le tabac.
PréventionHypertension
#2
Le milrinone peut-il être utilisé en prévention ?
Non, il est utilisé pour traiter l'insuffisance cardiaque, pas pour la prévention.
PréventionMilrinone
#3
Quels facteurs de risque sont évitables ?
L'obésité, le tabagisme et une mauvaise alimentation sont des facteurs évitables.
ObésitéTabagisme
#4
Comment surveiller les signes d'insuffisance cardiaque ?
Surveiller les symptômes comme l'essoufflement et la fatigue pour une détection précoce.
SurveillanceInsuffisance cardiaque
#5
Les examens réguliers aident-ils à prévenir l'insuffisance cardiaque ?
Oui, des examens réguliers peuvent aider à détecter des problèmes cardiaques précocement.
Examens médicauxPrévention
Traitements
5
#1
Comment le milrinone est-il administré ?
Il est généralement administré par voie intraveineuse dans un cadre hospitalier.
Administration intraveineuseMilrinone
#2
Le milrinone est-il utilisé seul ou en combinaison ?
Il est souvent utilisé en combinaison avec d'autres médicaments pour l'insuffisance cardiaque.
MédicamentsInsuffisance cardiaque
#3
Quelle est la durée du traitement par milrinone ?
La durée dépend de la réponse du patient, souvent de quelques jours à plusieurs semaines.
Durée du traitementRéponse au traitement
#4
Le milrinone nécessite-t-il une surveillance ?
Oui, une surveillance régulière des signes vitaux et des effets secondaires est nécessaire.
SurveillanceSignes vitaux
#5
Quels autres traitements complètent le milrinone ?
Des diurétiques et des inhibiteurs de l'enzyme de conversion peuvent être utilisés en complément.
DiurétiquesInhibiteurs de l'enzyme de conversion
Complications
5
#1
Quelles complications peuvent survenir avec le milrinone ?
Des complications comme l'hypotension et les arythmies peuvent survenir.
HypotensionArythmies
#2
Le milrinone peut-il causer des problèmes rénaux ?
Oui, une utilisation prolongée peut affecter la fonction rénale, nécessitant une surveillance.
Fonction rénaleSurveillance
#3
Comment gérer les complications liées au milrinone ?
La gestion inclut l'ajustement de la dose et la surveillance des signes vitaux.
Gestion des complicationsSurveillance
#4
Le milrinone augmente-t-il le risque d'infections ?
Il peut augmenter le risque d'infections en raison de l'immunosuppression potentielle.
InfectionsImmunosuppression
#5
Quelles sont les complications à long terme du milrinone ?
Les complications à long terme incluent des problèmes cardiaques persistants et des effets secondaires.
Complications à long termeEffets secondaires
Facteurs de risque
5
#1
Quels sont les principaux facteurs de risque d'insuffisance cardiaque ?
Les facteurs incluent l'hypertension, le diabète, et les antécédents familiaux de maladies cardiaques.
HypertensionDiabète
#2
Le mode de vie influence-t-il le risque d'insuffisance cardiaque ?
Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.
Mode de vieAlimentation
#3
L'âge est-il un facteur de risque pour le milrinone ?
Oui, le risque d'insuffisance cardiaque augmente avec l'âge, influençant l'utilisation du milrinone.
ÂgeInsuffisance cardiaque
#4
Le stress peut-il affecter la santé cardiaque ?
Oui, le stress chronique peut contribuer à des problèmes cardiaques et à l'insuffisance cardiaque.
StressSanté cardiaque
#5
Les antécédents médicaux influencent-ils le traitement par milrinone ?
Oui, des antécédents de maladies cardiaques ou rénales peuvent influencer le traitement.
Antécédents médicauxMilrinone
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"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme des nausées, des vomissements ou des troubles de la vision peuvent indiquer une surdose."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'insuffisance cardiaque ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un mode de vie sain, contrôler la pression artérielle et éviter le tabac."
}
},
{
"@type": "Question",
"name": "Le milrinone peut-il être utilisé en prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il est utilisé pour traiter l'insuffisance cardiaque, pas pour la prévention."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont évitables ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité, le tabagisme et une mauvaise alimentation sont des facteurs évitables."
}
},
{
"@type": "Question",
"name": "Comment surveiller les signes d'insuffisance cardiaque ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller les symptômes comme l'essoufflement et la fatigue pour une détection précoce."
}
},
{
"@type": "Question",
"name": "Les examens réguliers aident-ils à prévenir l'insuffisance cardiaque ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des examens réguliers peuvent aider à détecter des problèmes cardiaques précocement."
}
},
{
"@type": "Question",
"name": "Comment le milrinone est-il administré ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est généralement administré par voie intraveineuse dans un cadre hospitalier."
}
},
{
"@type": "Question",
"name": "Le milrinone est-il utilisé seul ou en combinaison ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est souvent utilisé en combinaison avec d'autres médicaments pour l'insuffisance cardiaque."
}
},
{
"@type": "Question",
"name": "Quelle est la durée du traitement par milrinone ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La durée dépend de la réponse du patient, souvent de quelques jours à plusieurs semaines."
}
},
{
"@type": "Question",
"name": "Le milrinone nécessite-t-il une surveillance ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance régulière des signes vitaux et des effets secondaires est nécessaire."
}
},
{
"@type": "Question",
"name": "Quels autres traitements complètent le milrinone ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des diurétiques et des inhibiteurs de l'enzyme de conversion peuvent être utilisés en complément."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le milrinone ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme l'hypotension et les arythmies peuvent survenir."
}
},
{
"@type": "Question",
"name": "Le milrinone peut-il causer des problèmes rénaux ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une utilisation prolongée peut affecter la fonction rénale, nécessitant une surveillance."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées au milrinone ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut l'ajustement de la dose et la surveillance des signes vitaux."
}
},
{
"@type": "Question",
"name": "Le milrinone augmente-t-il le risque d'infections ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il peut augmenter le risque d'infections en raison de l'immunosuppression potentielle."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications à long terme du milrinone ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications à long terme incluent des problèmes cardiaques persistants et des effets secondaires."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque d'insuffisance cardiaque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'hypertension, le diabète, et les antécédents familiaux de maladies cardiaques."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque d'insuffisance cardiaque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le milrinone ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque d'insuffisance cardiaque augmente avec l'âge, influençant l'utilisation du milrinone."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter la santé cardiaque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut contribuer à des problèmes cardiaques et à l'insuffisance cardiaque."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux influencent-ils le traitement par milrinone ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de maladies cardiaques ou rénales peuvent influencer le traitement."
}
}
]
}
]
}
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
Department of Anesthesiology and Critical Care Division, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada. andre.denault@umontreal.ca.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
The role of nimodipine and milrinone in the management of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) was studied using clinical and TCD (transcranial Doppler) param...
In this prospective observational study, patients with DCI after aneurysmal SAH presenting between November 2020 and June 2021 who were treated by either intra-arterial nimodipine (IAN) or intravenous...
Thirty-four patients fulfilled the inclusion criteria (IVM, 13/34 [38%]; IAN, 21/34 [62%]); patients in the IVM group (vs. IAN group) had poorer median Glasgow Coma Scale score (12 vs. 13), poorer mot...
In this single-center small study, patients in the IAN group had significantly less mortality compared with the IVM group in the management of DCI after aneurysmal SAH....
The aim of this study was to assess the safety and efficacy of long-term milrinone therapy in children with acute decompensated heart failure due to dilated cardiomyopathy (DCM)....
A single-centre retrospective study of all children ≤18 years with acute decompensated heart failure and DCM who received continuous long-term (≥7 consecutive days) intravenous milrinone between Janua...
The 47 patients had a median age of 3.3 months [interquartile range (IQR) 1.0-18.1], weight of 5.7 kg [IQR 4.3-10.1] and fractional shortening of 11.9% [±4.7]. Idiopathic DCM (n = 19) and myocarditis ...
Long-term intravenous milrinone is safe and effective in paediatric acute decompensated DCM. Combined with conventional heart failure therapies, it can act as a bridge to recovery and thereby potentia...
Mean arterial pressure to mean pulmonary arterial pressure ratio (mAP/mPAP) has been identified as a strong predictor of perioperative complications in cardiac surgery. We therefore investigated the p...
Knowledge on the spectral properties of the tautomers of milrinone (MLR) in solvents and solid-state, as well as under light conditions is of critical importance from both theoretical and practical po...
The symptom profile of children dying from cardiac disease, especially heart failure, differs from those with cancer and other non-cardiac conditions. Treatment with vasoactive infusions at home may b...
We report our experience using outpatient milrinone in children receiving hospice care for end-stage heart failure....
Retrospective review of a contemporary cohort of all patients at Lucile Packard Children's Hospital, Stanford who were discharged on intravenous milrinone and hospice care between 2008 and 2021. Clini...
Among 8 patients, median duration of home milrinone infusion was 191 (33, 572) days with the longest support duration 1,054 days. All (100%) patients were also receiving diuretics at the time of death...
We used milrinone with oral diuretics effectively for symptom control in children with heart failure on palliative care. Our experience was that this combination can be used safely in the outpatient s...
Both milrinone and levosimendan have been used in patients undergoing surgical closure of ventricular septal defects (VSD) with pulmonary artery hypertension (PAH); however, the evidence base for thei...
A prospective, randomized, controlled trial....
At a tertiary-care center....
Children between 1 month and 12 years presenting with VSD and PAH between 2018 and 2020....
A total of 132 patients were randomized into the following 2 groups: Group L (levosimendan group) and Group M (milrinone group)....
In addition to conventional hemodynamic parameters, the authors also included a myocardial performance index assessment to compare the groups. The levosimendan group had significantly lower mean arter...
In patients undergoing surgical repair for VSD with PAH, levosimendan does not confer any additional benefit compared to milrinone. Both milrinone and levosimendan appear to be safe in this cohort....
Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are major complications in cardiac surgery. This study aimed to evaluate the change in RV pressure waveform in patients receiving a c...
A prospective single-centre cohort study of adult patients undergoing cardiac surgery administered iE&iM through an ultrasonic mesh nebulizer. RV pressure waveform monitoring was obtained by continuou...
The final analysis included 26 patients receiving iE&iM. There was a significant drop in mean PA pressure (MPAP) (-4.8 ± 8.7, P = 0.010), systolic PA pressure (SPAP) (-8.2 ± 12.8, P = 0.003), RV end-d...
Coadministration of iE&iM in cardiac surgery patients presenting with PH or signs of RV dysfunction is a safe and effective treatment approach in improving RV function. Appearance of a transient incre...
The role of intravenous (IV) inotropes in the treatment of ambulatory patients with advanced heart failure (HF) remains controversial....
This was a retrospective study of patients with advanced HF. Patients on home IV milrinone, who remained on it for at least 3 months, were included. We compared the data from 3 months before starting ...
A total of 90 patients remained on continuous IV milrinone for 3 months, and 55 patients were treated for 6 months or longer. In both groups, improvements in cardiac index (1.86-2.25, p<0.001 and 1.9-...
Long-term IV use of milrinone is associated with improvement in haemodynamics, functional class, tolerance of medical therapy, and decrease in hospitalised days....
This study aims to determine the incidence of all-cause hospitalization in patients with advanced heart failure (AHF) receiving ambulatory continuous, intravenous dobutamine versus milrinone for palli...
We sought to describe and compare outcomes among advanced patients with heart failure (not candidates for orthotopic heart transplant/left ventricular assist device) on long-term milrinone or dobutami...
We included adults with refractory stage D heart failure who were not candidates for orthotopic heart transplant or left ventricular assist device and discharged on palliative dobutamine or milrinone....
The 1-year mortality from palliative inotropes remains high. Compared with dobutamine, use of milrinone was associated with improved survival owing to better optimization of guideline-directed medical...