Comment le milrinone est-il diagnostiqué pour l'insuffisance cardiaque ?
Le milrinone n'est pas un diagnostic, mais un traitement pour l'insuffisance cardiaque.
Insuffisance cardiaqueMilrinone
#2
Quels tests précèdent l'administration de milrinone ?
Des tests comme l'échocardiogramme et les analyses sanguines sont effectués.
ÉchocardiographieAnalyses sanguines
#3
Quand envisager le milrinone dans le diagnostic ?
Il est envisagé en cas d'insuffisance cardiaque sévère ou réfractaire aux autres traitements.
Insuffisance cardiaqueTraitement
#4
Le milrinone est-il utilisé pour le diagnostic précoce ?
Non, il est utilisé comme traitement, pas pour le diagnostic précoce.
DiagnosticMilrinone
#5
Quels signes cliniques indiquent l'utilisation de milrinone ?
Des signes comme la dyspnée et la fatigue peuvent indiquer son utilisation.
DyspnéeFatigue
Symptômes
5
#1
Quels symptômes le milrinone aide-t-il à soulager ?
Il aide à soulager les symptômes d'insuffisance cardiaque comme l'essoufflement.
EssoufflementInsuffisance cardiaque
#2
Le milrinone peut-il provoquer des effets secondaires ?
Oui, des effets comme des palpitations ou des maux de tête peuvent survenir.
Effets secondairesPalpitations
#3
Quels symptômes nécessitent une attention médicale avec milrinone ?
Des symptômes comme des douleurs thoraciques ou des éruptions cutanées doivent être signalés.
Douleurs thoraciquesÉruptions cutanées
#4
Le milrinone affecte-t-il la pression artérielle ?
Oui, il peut provoquer une hypotension, nécessitant une surveillance.
HypotensionSurveillance
#5
Quels symptômes indiquent une surdose de milrinone ?
Des symptômes comme des nausées, des vomissements ou des troubles de la vision peuvent indiquer une surdose.
SurdoseNausées
Prévention
5
#1
Comment prévenir l'insuffisance cardiaque ?
Maintenir un mode de vie sain, contrôler la pression artérielle et éviter le tabac.
PréventionHypertension
#2
Le milrinone peut-il être utilisé en prévention ?
Non, il est utilisé pour traiter l'insuffisance cardiaque, pas pour la prévention.
PréventionMilrinone
#3
Quels facteurs de risque sont évitables ?
L'obésité, le tabagisme et une mauvaise alimentation sont des facteurs évitables.
ObésitéTabagisme
#4
Comment surveiller les signes d'insuffisance cardiaque ?
Surveiller les symptômes comme l'essoufflement et la fatigue pour une détection précoce.
SurveillanceInsuffisance cardiaque
#5
Les examens réguliers aident-ils à prévenir l'insuffisance cardiaque ?
Oui, des examens réguliers peuvent aider à détecter des problèmes cardiaques précocement.
Examens médicauxPrévention
Traitements
5
#1
Comment le milrinone est-il administré ?
Il est généralement administré par voie intraveineuse dans un cadre hospitalier.
Administration intraveineuseMilrinone
#2
Le milrinone est-il utilisé seul ou en combinaison ?
Il est souvent utilisé en combinaison avec d'autres médicaments pour l'insuffisance cardiaque.
MédicamentsInsuffisance cardiaque
#3
Quelle est la durée du traitement par milrinone ?
La durée dépend de la réponse du patient, souvent de quelques jours à plusieurs semaines.
Durée du traitementRéponse au traitement
#4
Le milrinone nécessite-t-il une surveillance ?
Oui, une surveillance régulière des signes vitaux et des effets secondaires est nécessaire.
SurveillanceSignes vitaux
#5
Quels autres traitements complètent le milrinone ?
Des diurétiques et des inhibiteurs de l'enzyme de conversion peuvent être utilisés en complément.
DiurétiquesInhibiteurs de l'enzyme de conversion
Complications
5
#1
Quelles complications peuvent survenir avec le milrinone ?
Des complications comme l'hypotension et les arythmies peuvent survenir.
HypotensionArythmies
#2
Le milrinone peut-il causer des problèmes rénaux ?
Oui, une utilisation prolongée peut affecter la fonction rénale, nécessitant une surveillance.
Fonction rénaleSurveillance
#3
Comment gérer les complications liées au milrinone ?
La gestion inclut l'ajustement de la dose et la surveillance des signes vitaux.
Gestion des complicationsSurveillance
#4
Le milrinone augmente-t-il le risque d'infections ?
Il peut augmenter le risque d'infections en raison de l'immunosuppression potentielle.
InfectionsImmunosuppression
#5
Quelles sont les complications à long terme du milrinone ?
Les complications à long terme incluent des problèmes cardiaques persistants et des effets secondaires.
Complications à long termeEffets secondaires
Facteurs de risque
5
#1
Quels sont les principaux facteurs de risque d'insuffisance cardiaque ?
Les facteurs incluent l'hypertension, le diabète, et les antécédents familiaux de maladies cardiaques.
HypertensionDiabète
#2
Le mode de vie influence-t-il le risque d'insuffisance cardiaque ?
Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.
Mode de vieAlimentation
#3
L'âge est-il un facteur de risque pour le milrinone ?
Oui, le risque d'insuffisance cardiaque augmente avec l'âge, influençant l'utilisation du milrinone.
ÂgeInsuffisance cardiaque
#4
Le stress peut-il affecter la santé cardiaque ?
Oui, le stress chronique peut contribuer à des problèmes cardiaques et à l'insuffisance cardiaque.
StressSanté cardiaque
#5
Les antécédents médicaux influencent-ils le traitement par milrinone ?
Oui, des antécédents de maladies cardiaques ou rénales peuvent influencer le traitement.
Antécédents médicauxMilrinone
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},
{
"@type": "Question",
"name": "Quels symptômes indiquent une surdose de milrinone ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme des nausées, des vomissements ou des troubles de la vision peuvent indiquer une surdose."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'insuffisance cardiaque ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un mode de vie sain, contrôler la pression artérielle et éviter le tabac."
}
},
{
"@type": "Question",
"name": "Le milrinone peut-il être utilisé en prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il est utilisé pour traiter l'insuffisance cardiaque, pas pour la prévention."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont évitables ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité, le tabagisme et une mauvaise alimentation sont des facteurs évitables."
}
},
{
"@type": "Question",
"name": "Comment surveiller les signes d'insuffisance cardiaque ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller les symptômes comme l'essoufflement et la fatigue pour une détection précoce."
}
},
{
"@type": "Question",
"name": "Les examens réguliers aident-ils à prévenir l'insuffisance cardiaque ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des examens réguliers peuvent aider à détecter des problèmes cardiaques précocement."
}
},
{
"@type": "Question",
"name": "Comment le milrinone est-il administré ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est généralement administré par voie intraveineuse dans un cadre hospitalier."
}
},
{
"@type": "Question",
"name": "Le milrinone est-il utilisé seul ou en combinaison ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est souvent utilisé en combinaison avec d'autres médicaments pour l'insuffisance cardiaque."
}
},
{
"@type": "Question",
"name": "Quelle est la durée du traitement par milrinone ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La durée dépend de la réponse du patient, souvent de quelques jours à plusieurs semaines."
}
},
{
"@type": "Question",
"name": "Le milrinone nécessite-t-il une surveillance ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance régulière des signes vitaux et des effets secondaires est nécessaire."
}
},
{
"@type": "Question",
"name": "Quels autres traitements complètent le milrinone ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des diurétiques et des inhibiteurs de l'enzyme de conversion peuvent être utilisés en complément."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le milrinone ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme l'hypotension et les arythmies peuvent survenir."
}
},
{
"@type": "Question",
"name": "Le milrinone peut-il causer des problèmes rénaux ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une utilisation prolongée peut affecter la fonction rénale, nécessitant une surveillance."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées au milrinone ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut l'ajustement de la dose et la surveillance des signes vitaux."
}
},
{
"@type": "Question",
"name": "Le milrinone augmente-t-il le risque d'infections ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il peut augmenter le risque d'infections en raison de l'immunosuppression potentielle."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications à long terme du milrinone ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications à long terme incluent des problèmes cardiaques persistants et des effets secondaires."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque d'insuffisance cardiaque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'hypertension, le diabète, et les antécédents familiaux de maladies cardiaques."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque d'insuffisance cardiaque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le milrinone ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque d'insuffisance cardiaque augmente avec l'âge, influençant l'utilisation du milrinone."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter la santé cardiaque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut contribuer à des problèmes cardiaques et à l'insuffisance cardiaque."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux influencent-ils le traitement par milrinone ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de maladies cardiaques ou rénales peuvent influencer le traitement."
}
}
]
}
]
}
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
Department of Anesthesiology and Critical Care Division, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada. andre.denault@umontreal.ca.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
From the CAPITAL Research Group, Division of Cardiology (R.M., P.D.S., R.G.J., J.A.M., T.S., F.D.R., D.T.H., O.A.-R., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Cardiovascular Research Methods Centre (J.B., G.A.W.), and the Division of Cardiac Surgery (V.C.), University of Ottawa Heart Institute, and the Faculty of Medicine (R.M., P.D.S., R.G.J., J.H., D.T.H., W.W., O.A.-R., S.M.F., K.K., M.F., M.L., M.R.L.M., J.J.R., B.H.), the Division of Critical Care, Department of Medicine (R.M., J.H., S.M.F., K.K.), the School of Epidemiology and Public Health (P.D.S.), and the Department of Cellular and Molecular Medicine (R.G.J., T.S., B.H.), University of Ottawa, Ottawa, the Division of Cardiology, University of Toronto, Toronto (A.M.), and the Division of Cardiology, University of British Columbia, Vancouver (A.A.) - all in Canada; the Division of Critical Care, Tufts Medical Center, Boston (J.A.M.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (T.S.); and Hôpital Cardiologique du Haut Lévêque, Centre Hospitalier Universitaire Bordeaux (F.D.R.), and LIRYC (L'Institut de Rythmologie et Modélisation Cardiaque) (F.D.R.) - both in Bordeaux-Pessac, France.
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Pregnancy in a patient with pulmonary hypertension carries a high risk of mortality. It poses multiple problems in the management of pregnancy, labor, and postpartum, thereby emphasizing the need for ...
Accidental hypothermia, recognized by core temperature below 35 °C, is a lethal condition with a mortality rate up to 25%. Hypothermia-induced cardiac dysfunction causing increased total peripheral re...
Using an experimental in vitro-design, levosimendan, milrinone and isoprenaline were incubated with iCell...
Milrinone and isoprenaline both significantly increases action potential triangulation during hypothermia, and thereby the risk of ventricular arrhythmias. Levosimendan, however, does not increase tri...
Levosimendan remains a promising candidate drug for inotropic treatment of hypothermic patients as it possesses ability to treat hypothermia-induced cardiac dysfunction and no increased risk of ventri...
Milrinone is widely used for enhancing myocardial contractility, however, there is inadequate data to suggest whether it is preferable to other inotropic agents in critically ill patients. To observe ...
A search of the following databases was conducted: Medline, Elsevier, Cochrane Central Register of Controlled Trials and Web of Science databases, and eligible randomized controlled trials including a...
Twenty studies including 2036 critically ill patients which compared milrinone with control group were enrolled. When compared to control group, there was no significant difference of all-cause mortal...
The meta-analysis showed when compared with control group, although no significant reduction in mortality and the incidence of myocardial infarction was found in the milrinone group, the incidence of ...
Milrinone is administered after patent ductus arteriosus (PDA) ligation to prevent and treat postoperative hemodynamic instability (i.e., postligation cardiac syndrome). We aimed to explore the effect...
Using the Japanese Diagnosis Procedure Combination database, we identified patients who received milrinone after PDA ligation (n = 428) in neonatal intensive care units between July 2010 and March 202...
In-hospital morbidity, bronchopulmonary dysplasia, intraventricular hemorrhage, and necrotizing enterocolitis occurred in 58%, 48%, 9.5%, and 7.1% of patients, respectively; the in-hospital mortality ...
Milrinone use after PDA ligation was not associated with improved in-hospital outcomes, such as mortality and morbidity....
Children with congenital heart disease (CHD) are easily complicated by severe pneumonia and heart failure. We aimed to conduct a meta-analysis to evaluate the effects and safety of milrinone for the t...
Two authors searched MEDLINE, PubMed, Embase, Science Direct, Cochrane Central Register of Controlled Trials, the Cochrane Library, Wanfang database, Chinese Biomedical Literature Database, China Nati...
Eight RCTs involving 680 CHD children complicated by severe pneumonia and heart failure were included in this meta-analysis. Meta-analysis indicated that total effective rate of the milrinone group wa...
Milrinone is beneficial to improve clinical symptoms and cardiac function and increase the therapeutic effect and safety in children with CHD complicated by severe pneumonia and heart failure. However...
To evaluate milrinone's impact on pediatric cardiac function, focusing on its specific role as an inotrope and lusitrope, while considering its systemic and pulmonary vasodilatory effects. Search of P...
Our meta-analysis suggests potential clinical benefits of milrinone by improving cardiac function, likely driven by its systemic vasodilatory effects. However, questions arise about its inotropic infl...
• Milrinone is a phosphodiesterase III inhibitor that has been used to treat a variety of pediatric and neonatal conditions. • Milrinone is believed to exert its therapeutic effects by enhancing cardi...
• Milrinone may not have a significant inotropic effect. • Milrinone's pulmonary vasodilatory effect is less robust than its systemic vasodilatory effect....
Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH) is a singular pathological entity necessitating early diagnostic approaches and both prophylactic and curative interven...
Conventional anesthesia used to reduce central venous pressure (CVP) during hepatectomy includes fluid restriction and vasodilator drugs, which can lead to a reduction in blood perfusion in vital orga...
In total, 68 patients undergoing LH under LCVP were randomly divided into the milrinone group (n = 34) and the nitroglycerin group (n = 34). Milrinone was infused with a loading dose of 10 µg/kg follo...
Blood loss during hepatectomy and total blood loss were significantly lower in the milrinone group compared with those in the nitroglycerin group (P < 0.05). Both the nitroglycerin group and milrinone...
Our findings indicate that the intraoperative infusion of milrinone can help in maintaining an LCVP and hemodynamic stability during LH while reducing intraoperative blood loss and providing a better ...
ChiCTR2200056891,first registered on 22/02/2022....
Inhaled nitric oxide (iNO) has a beneficial effect on hypoxemic respiratory failure. The increased use of concurrent iNO and milrinone was observed. We aimed to report the trends of iNO use in the pas...
This nationwide cohort study enrolled preterm singleton infants with birth weight <1500g treated with iNO from 2004 to 2019. Infants were divided into two groups, with a combination of intravenous mil...
After PSM, more infants in Group 2 needed inotropes. The mortality rate was significantly higher in Group 2 than in Group 1 from one month after birth till 1 year of age (55.1% vs. 13.5%) with the adj...
Combined treatment of iNO and milrinone is increasingly applied in VLBWP infants in Taiwan. This retrospective study did not support the benefits of combining iNO and milrinone on one-year survival an...
Persistent pulmonary hypertension of the newborn (PPHN) is a common neonatal condition in newborns admitted to the neonatal intensive care units (NICUs). PPHN has still a high mortality and morbidity....