Régions 5' non traduites : Questions médicales fréquentes
Nom anglais: 5' Untranslated Regions
Descriptor UI:D020121
Tree Number:G05.360.340.024.340.137.910.885
Termes MeSH sélectionnés :
Controlled Substances
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"name": "Diagnostic",
"headline": "Diagnostic sur Régions 5' non traduites",
"description": "Comment identifier les 5' UTR dans un gène ?\nQuels tests sont utilisés pour étudier les 5' UTR ?\nLes 5' UTR sont-elles visibles sur des électrophorèses ?\nPeut-on détecter des mutations dans les 5' UTR ?\nQuel rôle jouent les 5' UTR dans le diagnostic ?",
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"description": "Les 5' UTR sont-elles liées à des symptômes cliniques ?\nQuels symptômes peuvent indiquer un problème avec les 5' UTR ?\nLes 5' UTR affectent-elles la réponse aux traitements ?\nPeut-on relier les 5' UTR à des syndromes spécifiques ?\nLes 5' UTR sont-elles impliquées dans des cancers ?",
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"description": "Peut-on prévenir les anomalies des 5' UTR ?\nY a-t-il des facteurs environnementaux affectant les 5' UTR ?\nComment le mode de vie influence-t-il les 5' UTR ?\nLes dépistages génétiques aident-ils à prévenir les problèmes liés aux 5' UTR ?\nLes vaccinations influencent-elles les 5' UTR ?",
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"description": "Comment les traitements ciblent-ils les 5' UTR ?\nLes médicaments peuvent-ils interagir avec les 5' UTR ?\nY a-t-il des traitements pour corriger les anomalies des 5' UTR ?\nLes traitements ciblant les 5' UTR sont-ils efficaces ?\nLes 5' UTR influencent-elles la résistance aux traitements ?",
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"description": "Quelles complications peuvent survenir avec des anomalies des 5' UTR ?\nLes anomalies des 5' UTR peuvent-elles entraîner des complications héréditaires ?\nComment les 5' UTR affectent-elles le pronostic des maladies ?\nLes complications liées aux 5' UTR sont-elles réversibles ?\nLes 5' UTR sont-elles impliquées dans des complications post-thérapeutiques ?",
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"description": "Quels sont les facteurs de risque pour les anomalies des 5' UTR ?\nL'âge est-il un facteur de risque pour les anomalies des 5' UTR ?\nLes habitudes alimentaires influencent-elles les 5' UTR ?\nLe stress peut-il affecter les 5' UTR ?\nLes infections virales sont-elles un facteur de risque pour les anomalies des 5' UTR ?",
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"@type": "Question",
"name": "Comment identifier les 5' UTR dans un gène ?",
"position": 1,
"acceptedAnswer": {
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"text": "Les 5' UTR peuvent être identifiées par séquençage d'ARN et analyse bioinformatique."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour étudier les 5' UTR ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent le RT-PCR et les analyses de l'expression génique."
}
},
{
"@type": "Question",
"name": "Les 5' UTR sont-elles visibles sur des électrophorèses ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent être visualisées sur des gels d'électrophorèse après amplification."
}
},
{
"@type": "Question",
"name": "Peut-on détecter des mutations dans les 5' UTR ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations peuvent être détectées par séquençage ciblé des régions 5' UTR."
}
},
{
"@type": "Question",
"name": "Quel rôle jouent les 5' UTR dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles influencent la régulation de l'expression génique, affectant le diagnostic de maladies."
}
},
{
"@type": "Question",
"name": "Les 5' UTR sont-elles liées à des symptômes cliniques ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans les 5' UTR peuvent entraîner des symptômes variés selon le gène affecté."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les 5' UTR ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes peuvent inclure des troubles métaboliques ou des maladies neurodégénératives."
}
},
{
"@type": "Question",
"name": "Les 5' UTR affectent-elles la réponse aux traitements ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des variations dans les 5' UTR peuvent influencer l'efficacité des traitements médicamenteux."
}
},
{
"@type": "Question",
"name": "Peut-on relier les 5' UTR à des syndromes spécifiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines mutations dans les 5' UTR sont associées à des syndromes génétiques spécifiques."
}
},
{
"@type": "Question",
"name": "Les 5' UTR sont-elles impliquées dans des cancers ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des altérations dans les 5' UTR peuvent contribuer à la carcinogenèse dans certains cancers."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les anomalies des 5' UTR ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention passe par des conseils génétiques et un suivi médical pour les familles à risque."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs environnementaux affectant les 5' UTR ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains facteurs environnementaux peuvent influencer l'expression des gènes liés aux 5' UTR."
}
},
{
"@type": "Question",
"name": "Comment le mode de vie influence-t-il les 5' UTR ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain peut réduire le risque d'anomalies génétiques, y compris celles des 5' UTR."
}
},
{
"@type": "Question",
"name": "Les dépistages génétiques aident-ils à prévenir les problèmes liés aux 5' UTR ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le dépistage génétique peut identifier les risques et permettre une intervention précoce."
}
},
{
"@type": "Question",
"name": "Les vaccinations influencent-elles les 5' UTR ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccinations n'affectent pas directement les 5' UTR, mais protègent contre certaines maladies."
}
},
{
"@type": "Question",
"name": "Comment les traitements ciblent-ils les 5' UTR ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies géniques et des oligonucléotides peuvent cibler les 5' UTR pour moduler l'expression."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils interagir avec les 5' UTR ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent moduler l'activité des 5' UTR, influençant la traduction."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements pour corriger les anomalies des 5' UTR ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des approches de thérapie génique sont en développement pour corriger ces anomalies."
}
},
{
"@type": "Question",
"name": "Les traitements ciblant les 5' UTR sont-ils efficaces ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité dépend du type de mutation et du contexte biologique de la maladie."
}
},
{
"@type": "Question",
"name": "Les 5' UTR influencent-elles la résistance aux traitements ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des variations dans les 5' UTR peuvent être liées à la résistance aux traitements anticancéreux."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies des 5' UTR ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications peuvent inclure des maladies métaboliques, des cancers ou des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Les anomalies des 5' UTR peuvent-elles entraîner des complications héréditaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies peuvent être transmises et causer des complications héréditaires."
}
},
{
"@type": "Question",
"name": "Comment les 5' UTR affectent-elles le pronostic des maladies ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les variations dans les 5' UTR peuvent influencer le pronostic et la réponse au traitement."
}
},
{
"@type": "Question",
"name": "Les complications liées aux 5' UTR sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles selon la maladie."
}
},
{
"@type": "Question",
"name": "Les 5' UTR sont-elles impliquées dans des complications post-thérapeutiques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des modifications dans les 5' UTR peuvent contribuer à des complications après traitement."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les anomalies des 5' UTR ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, des expositions environnementales et des mutations."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour les anomalies des 5' UTR ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge avancé peut augmenter le risque de mutations dans les 5' UTR et d'autres gènes."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles les 5' UTR ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines habitudes alimentaires peuvent affecter l'expression des gènes, y compris les 5' UTR."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter les 5' UTR ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut influencer l'expression génique et potentiellement affecter les 5' UTR."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles un facteur de risque pour les anomalies des 5' UTR ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales peuvent induire des modifications dans les 5' UTR, augmentant les risques."
}
}
]
}
]
}
In the United States, the scheduling system for controlled substances was established by the Controlled Substance Act of 1970. In 2009, Parker et al. published the study "Physicians' knowledge and att...
To follow up on a 2009 survey by Parker, et al. to determine prescribers' knowledge and attitudes regarding the controlled substance scheduling system and assess the impact of the controlled substance...
The cross-sectional survey was designed to assess prescribers' attitudes and mailed to 400 randomly selected physicians and 400 randomly selected nurse practitioners....
Prescribers across all groups provided consistent responses suggesting an overall lack of understanding of controlled substance regulations, a negative attitude towards the controlled substance schedu...
The results of this survey confirm the findings of Parker, et al., and further display the need for investigation into how to improve the controlled substance scheduling system in the United States....
Impulsivity and substance use disorders (SUD) have been both associated with changes in dopaminergic processes. In this study, we intended to evaluate the dopaminergic function in imprisoned SUD offen...
The study included 46 male individuals from a Portuguese penal institution. The participants were assessed through a battery of standardised instruments: Psychopathy Checklist-Revised (PCL-R), Barratt...
Overall, 73.9% (n = 34) of the individuals had Antisocial personality disorder (ASPD) and 58.7% (n = 27) presented SUD. We evidenced, for the first time, that, in individuals with SUD, s-COMT activity...
This study opens new perspectives regarding the pharmacological intervention on substance dependence through the interference on dopamine pathways....
The presence of potentially hazardous substances in fruit wines poses a threat for human health. However, the management standards and specifications of hazardous substances contained within various t...
While research on substance using youth experiencing homelessness (YEH) is increasing, there is a dearth of information regarding effective prevention interventions for these youth. Suicide is the lea...
Three hundred (N = 300) YEH with recent substance use and suicidal ideation or a recent suicide attempt will be recruited from the streets as well as a drop-in center serving YEH. After the baseline a...
This study adds to a very small number of clinical trials seeking to prevent lethal suicide among a very high-risk group by addressing suicidal ideation directly rather than underlying conditions. It ...
NCT05994612. Date of Registration: August 16, 2023....
Addiction is a significant problem among many Native American groups but has rarely been examined in urban populations. In particular, little is known about the context in which urban Native Americans...
The trained Native American lay research assistants recruited community members and administered surveys. They first asked questions regarding the criteria for substance use disorders. Individuals who...
Both groups reported a relatively young age of first substance use (age 16 years for cases and age 15 years for controls). Alcohol was the first substance most commonly used in both groups. Controls r...
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are post...
This study investigated the impact of an advanced analytics software solution in the operating room (OR) on tracking and evaluating controlled substance discrepancies. The authors hypothesized that th...
In this evaluation comparing data from before to after implementation of the software, data were collected using the preexisting manual process for 50 days before implementation, followed by a 25-day ...
Before implementation of the analytics software, there were 7,635 OR cases with a total of 674 charting discrepancies (8.83 discrepancies per 100 total OR cases) discovered across 439 OR cases. After ...
Implementation of advanced analytics software in the OR significantly increased the number of controlled substance charting discrepancies identified compared to the preimplementation review process wh...
This study aimed to assess the influence of continuous rotation and reciprocation kinematics on postoperative pain (POP) levels and substance P (SP) levels in patients diagnosed with irreversible pulp...
A total of twenty patients were randomly assigned into two groups: Continuous Rotation Group (CRG) (n = 10), subjected to mechanical preparation with the EdgeEndox7 rotary system (Albuquerque, NM, USA...
There was a significant increase in SP levels in the reciprocating group compared to the continuous rotation group (P ≤ 0.05). Additionally, patients in the reciprocating group reported significantly ...
Our findings suggest that continuous rotation kinematics in root canal preparation leads to a considerable reduction in SP expression and POP....
The study protocol was retrospectively registered on the www....
gov database (NCT06081335) at (13/10/2023) after the approval of the Ethics Committee, Faculty of Dentistry, Ain Shams University (FDASU-RecIM012135)....
As persistent organic pollutants (POPs), perfluoroalkyl substances (PFAS) may potentially impact human health. Our study aimed to investigate the prospective association between PFAS exposure and the ...
By fully following the Jinchang Cohort after a decade, we conducted this nested case-control study with 135 incidence cases of breast cancer (BC) and 540 bias-paired controls. The PFAS levels were tes...
Exposures to specific PFAS components were positively associated with an increased incidence risk of breast cancer. By grouping the study population into different baseline menopausal statuses, PFHxS,...
Our findings suggest a strong association between PFAS exposure and the incidence of breast cancer. Premenopausal women should exercise more caution regarding PFAS exposure....
The purpose of this study was to determine if controlled substance waste management systems (CSWMS) demonstrate microbial growth, and therefore present a potential infection risk to pediatric hospital...
Twenty CSWMS, either Smart Sink or Pharma Lock systems, located in patient care areas were sampled. Twelve were located in critical care areas. Cultures were obtained by swabbing the drain grate with ...
Of the CSWMS sampled, 50% demonstrated bacterial or fungal growth with a total of 15 microorganisms isolated, including 3 systems with...
Controlled substance waste management systems harbor potential pathogens and may serve as reservoirs of infectious agents in pediatric hospitals. Microbial growth was identified in more than half of s...
Substance use disorders (SUDs) are prevalent and compromise health and wellbeing. Scalable solutions, such as digital therapeutics, may offer a population-based strategy for addressing SUDs. Two forma...
To further develop the evidence base, the current randomized trial extends follow-up to 1-month post-treatment and will test the efficacy of W-SUDs relative to a psychoeducational control....
This study will recruit, screen, and consent 400 adults online reporting problematic substance use. Following baseline assessment, participants will be randomized to 8 weeks of W-SUDs or a psychoeduca...
The current study builds upon emerging evidence of a digital therapeutic for reducing problematic substance use by examining sustained effects and testing against a psychoeducational control condition...
NCT04925570....
