Régions 5' non traduites : Questions médicales fréquentes
Nom anglais: 5' Untranslated Regions
Descriptor UI:D020121
Tree Number:G05.360.340.024.340.137.910.885
Termes MeSH sélectionnés :
Delphi Technique
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"description": "Comment identifier les 5' UTR dans un gène ?\nQuels tests sont utilisés pour étudier les 5' UTR ?\nLes 5' UTR sont-elles visibles sur des électrophorèses ?\nPeut-on détecter des mutations dans les 5' UTR ?\nQuel rôle jouent les 5' UTR dans le diagnostic ?",
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"description": "Comment les traitements ciblent-ils les 5' UTR ?\nLes médicaments peuvent-ils interagir avec les 5' UTR ?\nY a-t-il des traitements pour corriger les anomalies des 5' UTR ?\nLes traitements ciblant les 5' UTR sont-ils efficaces ?\nLes 5' UTR influencent-elles la résistance aux traitements ?",
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"@type": "Question",
"name": "Comment identifier les 5' UTR dans un gène ?",
"position": 1,
"acceptedAnswer": {
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"text": "Les 5' UTR peuvent être identifiées par séquençage d'ARN et analyse bioinformatique."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour étudier les 5' UTR ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent le RT-PCR et les analyses de l'expression génique."
}
},
{
"@type": "Question",
"name": "Les 5' UTR sont-elles visibles sur des électrophorèses ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent être visualisées sur des gels d'électrophorèse après amplification."
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{
"@type": "Question",
"name": "Peut-on détecter des mutations dans les 5' UTR ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations peuvent être détectées par séquençage ciblé des régions 5' UTR."
}
},
{
"@type": "Question",
"name": "Quel rôle jouent les 5' UTR dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles influencent la régulation de l'expression génique, affectant le diagnostic de maladies."
}
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{
"@type": "Question",
"name": "Les 5' UTR sont-elles liées à des symptômes cliniques ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans les 5' UTR peuvent entraîner des symptômes variés selon le gène affecté."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les 5' UTR ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes peuvent inclure des troubles métaboliques ou des maladies neurodégénératives."
}
},
{
"@type": "Question",
"name": "Les 5' UTR affectent-elles la réponse aux traitements ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des variations dans les 5' UTR peuvent influencer l'efficacité des traitements médicamenteux."
}
},
{
"@type": "Question",
"name": "Peut-on relier les 5' UTR à des syndromes spécifiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines mutations dans les 5' UTR sont associées à des syndromes génétiques spécifiques."
}
},
{
"@type": "Question",
"name": "Les 5' UTR sont-elles impliquées dans des cancers ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des altérations dans les 5' UTR peuvent contribuer à la carcinogenèse dans certains cancers."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les anomalies des 5' UTR ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention passe par des conseils génétiques et un suivi médical pour les familles à risque."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs environnementaux affectant les 5' UTR ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains facteurs environnementaux peuvent influencer l'expression des gènes liés aux 5' UTR."
}
},
{
"@type": "Question",
"name": "Comment le mode de vie influence-t-il les 5' UTR ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain peut réduire le risque d'anomalies génétiques, y compris celles des 5' UTR."
}
},
{
"@type": "Question",
"name": "Les dépistages génétiques aident-ils à prévenir les problèmes liés aux 5' UTR ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le dépistage génétique peut identifier les risques et permettre une intervention précoce."
}
},
{
"@type": "Question",
"name": "Les vaccinations influencent-elles les 5' UTR ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccinations n'affectent pas directement les 5' UTR, mais protègent contre certaines maladies."
}
},
{
"@type": "Question",
"name": "Comment les traitements ciblent-ils les 5' UTR ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies géniques et des oligonucléotides peuvent cibler les 5' UTR pour moduler l'expression."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils interagir avec les 5' UTR ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent moduler l'activité des 5' UTR, influençant la traduction."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements pour corriger les anomalies des 5' UTR ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des approches de thérapie génique sont en développement pour corriger ces anomalies."
}
},
{
"@type": "Question",
"name": "Les traitements ciblant les 5' UTR sont-ils efficaces ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité dépend du type de mutation et du contexte biologique de la maladie."
}
},
{
"@type": "Question",
"name": "Les 5' UTR influencent-elles la résistance aux traitements ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des variations dans les 5' UTR peuvent être liées à la résistance aux traitements anticancéreux."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies des 5' UTR ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications peuvent inclure des maladies métaboliques, des cancers ou des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Les anomalies des 5' UTR peuvent-elles entraîner des complications héréditaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies peuvent être transmises et causer des complications héréditaires."
}
},
{
"@type": "Question",
"name": "Comment les 5' UTR affectent-elles le pronostic des maladies ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les variations dans les 5' UTR peuvent influencer le pronostic et la réponse au traitement."
}
},
{
"@type": "Question",
"name": "Les complications liées aux 5' UTR sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles selon la maladie."
}
},
{
"@type": "Question",
"name": "Les 5' UTR sont-elles impliquées dans des complications post-thérapeutiques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des modifications dans les 5' UTR peuvent contribuer à des complications après traitement."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les anomalies des 5' UTR ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, des expositions environnementales et des mutations."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour les anomalies des 5' UTR ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge avancé peut augmenter le risque de mutations dans les 5' UTR et d'autres gènes."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles les 5' UTR ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines habitudes alimentaires peuvent affecter l'expression des gènes, y compris les 5' UTR."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter les 5' UTR ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut influencer l'expression génique et potentiellement affecter les 5' UTR."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles un facteur de risque pour les anomalies des 5' UTR ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales peuvent induire des modifications dans les 5' UTR, augmentant les risques."
}
}
]
}
]
}
An adequate healthcare workforce remains essential for the health of rural communities. Strategies to address rural health workforce challenges have often centred on the medical and nursing workforce;...
A modified Delphi technique was employed to develop the PharmCAQ. A panel of experts were purposively selected. Eight representatives were from organisations with rural experience relevant to the stud...
Fifty key factors that impact the recruitment and retention of pharmacists were identified, developed and succinctly described. All factors were grouped into five classifications: (1) geographic, (2) ...
While the development and use of the Apgar questionnaire for the recruitment and retention of health professionals is not a novel idea, seeking to specifically focus on pharmacists is unique. However,...
Sport-related concussions (SRCs) affect millions of adolescents and young adults annually in the USA; however, current SRC consensus statements provide limited guidance on academic support for student...
To generate consensus on appropriate academic recommendations for clinicians, students, and academic stakeholders to support university students during their recovery....
Panelists participated in three stages of a modified Delphi procedure: the first stage included a series of open-ended questions after reviewing a literature review on post-SRC return-to-learn (RTL) i...
Twenty-two panelists including clinicians, concussion researchers, and academic stakeholders (54.5% female) from 15 institutions and/or healthcare systems participated in a modified Delphi procedure. ...
There are several unique challenges when assisting university students back to the classroom after SRC. Explicit guidelines on when to seek additional medical care (e.g., if they are experiencing wors...
Innovations in models of care for older adults living with frailty presenting to the emergency department (ED) have become a key priority for clinicians, researchers and policymakers due to the delete...
A modified real-time Delphi method was used. Facilitation of World Café focus groups with an expert panel of 86 members and seperate advisory groups with a Public and Patient Involvement panel of olde...
Fifty members responded to the survey representing an overall response rate of 58%. Following analyses of the survey responses, the research team reviewed statements for content overlap and refined a ...
Development of a consensus derived FFD model of care represents an important step in generating national standards, implementation of a service model as intended and enhances opportunities for scienti...
A major group of the population, especially antenatal checkup (ANC) mothers and their spouses, people admitted for surgery, and people attending STI clinics, are reluctant to pretest counseling....
This study has been taken up to explore the barriers and possible solutions to improve the utilization of Facility based integrated counseling and testing center (F-ICTC) counseling services....
Phase 1: In-depth interview and ranking with stakeholders from the F-ICTC center (n = 13) were conducted to identify the barriers to utilization of F-ICTC and solution for the same. Phase 2....
Delphi panel with experts (n = 17) was invited through mail to find out the potential solution to improve the utilization of F-ICTC counseling services....
Possible barriers from the stakeholders' perspectives were fear of the disease, violate the privacy, unacceptance, gender bias, fear of social stigma and discrimination, and neglect attached to the di...
Context-specific proactive evidence-based intervention will help in improving the proper utilization of the F-ICTC center....
Internationally, the need for appropriately structured, high-quality care in psycho-oncology is more and more recognized and quality-oriented care is to be established. Quality indicators are becoming...
The widely established RAND/UCLA Appropriateness Method was combined with a modified Delphi technique. A systematic literature review was conducted to identify existing indicators. All identified indi...
Of the 88 potential indicators derived from a systematic literature review and other sources, 29 were deemed relevant in the first Delphi round. After the first expert panel, 28 of the dissented indic...
The developed set of quality indicators has proven in practical testing to be a valid quality assurance tool for internal and external quality management. The study findings could contribute to tracea...
"Entwicklung eines Qualitätsmanagementsystems in der integrierten, sektorenübergreifenden Psychoonkologie-AP "Qualitätsmanagement und Versorgungsmanagement" zur Studie "integrierte, sektorenübergreife...
Surgical management of splenic flexure carcinoma remains controversial....
This study aimed to establish an expert international consensus on splenic flexure carcinoma management....
A 3-round online-based Delphi study was conducted between September 2020 and April 2021....
The first round included 18 experts from 12 different countries. For the second and third rounds, each expert in the first round was asked to invite 2 more colorectal surgeons (n = 47). Out of 47 invi...
A total of 35 questions were created and sent via the online questionnaire tool....
Levels of recommendation based on voting concordance were graded as follows: more than 75% agreement was defined as strong, between 50% and 75% as moderate, and below 50% as weak....
There was moderate consensus on the definition of splenic flexure (55%) as 10 cm from either side where the distal transverse colon turns into the proximal descending colon. Also, experts recommended ...
Subjective decisions are based on individual expert clinical experience and not evidence based....
This is the first internationally conducted Delphi consensus study regarding splenic flexure carcinoma. The definition of splenic flexure remains ambiguous. To more effectively compare oncologic outco...
ANTECEDENTES:El tratamiento quirúrgico del cáncer de ángulo esplénico sigue siendo controvertido.OBJETIVO:Establecer un consenso internacional de expertos sobre el manejo del cáncer del ángulo espléni...
Chronic kidney disease (CKD) is a common condition, especially in the elderly. In order to prevent progression and complications of the disease, guideline-adherent outpatient care of patients with CKD...
QIs were operationalized from the recommendations of the German national guideline for CKD and others were proposed based on a published review of international QIs. The resulting QIs were divided int...
An incidence indicator and a prevalence indicator were established; these were not subject to vote. Further, 21 QIs were voted upon by the expert panel. The seven most important QIs in each set (billi...
The QIs will enable the evaluation of the quality of outpatient care for patients with CKD with the long-term aim of optimizing guideline-adherent outpatient care....
Chemotherapy-related cognitive impairment (CRCI) is a well-known phenomenon among breast cancer survivors. Cognitive impairment among breast cancer survivors can significantly affect their quality of ...
The Delphi consensus technique was conducted online to review and evaluate the framework module. A panel of experts, including rehabilitation medicine physicians, occupational therapists, and clinical...
A total of 33 practitioners completed the three Delphi rounds. 72.7% of the expert panel have been practising in their relevant clinical fields for more than six years (M = 10.67, SD = 5.68). In Round...
This study found out that the cognitive intervention framework module for breast cancer survivors with cognitive impairment following chemotherapy can be successfully developed and feasible to be impl...
Our objective was to establish a standardized technique for Anatomical Endoscopic Enucleation of Prostate (AEEP) utilizing a consensus statement to provide robust recommendations for urologists who ar...
The participants were electronically sent a questionnaire in three consecutive rounds. In the second and third rounds, the anonymous aggregate results of the previous round were presented. Experts' fe...
Forty-one urologists participated in the first round. In the second round, all Round 1 participants received a 22-question survey, resulting in a consensus on 21 items. In the third round, 76% (19/25)...
To optimize laser AEEP procedures, urologists must follow expert guidelines on equipment and surgical technique, including early apical release, using the 3-lobe technique for enucleation, preserving ...
This paper aimed to develop a harm reduction model to reduce exposure to environmental tobacco smoke among children of rural households in Bangladesh. A mixed-methods exploratory sequential design has...
