Comment la chimie combinatoire aide-t-elle au diagnostic ?

Elle permet de créer des bibliothèques de composés pour identifier des biomarqueurs.

Quels outils sont utilisés pour le diagnostic en chimie combinatoire ?

Des techniques comme la spectrométrie de masse et la chromatographie sont courantes.

Quels symptômes peuvent être ciblés par des composés issus de la chimie combinatoire ?

Des symptômes variés comme la douleur, l'inflammation ou des troubles neurologiques.

La chimie combinatoire peut-elle aider à identifier des symptômes ?

Oui, en développant des molécules qui interagissent avec des cibles biologiques spécifiques.

La chimie combinatoire joue-t-elle un rôle dans la prévention des maladies ?

Oui, en développant des agents préventifs et des vaccins ciblés.

Quels composés préventifs sont issus de la chimie combinatoire ?

Des inhibiteurs d'enzymes ou des modulateurs de récepteurs pour prévenir des maladies.

Quels types de traitements sont développés par la chimie combinatoire ?

Des traitements pour des maladies comme le cancer, le diabète et les infections.

Comment la chimie combinatoire améliore-t-elle les traitements ?

Elle permet de découvrir des médicaments plus efficaces et avec moins d'effets secondaires.

Quelles complications peuvent survenir avec des traitements issus de la chimie combinatoire ?

Des complications comme des réactions allergiques ou des résistances médicamenteuses.

Comment minimiser les complications des traitements ?

En optimisant la structure des composés pour réduire les effets indésirables.

Quels facteurs de risque sont pris en compte en chimie combinatoire ?

Des facteurs comme la génétique, l'environnement et le mode de vie des patients.

Comment la chimie combinatoire évalue-t-elle les facteurs de risque ?

En développant des modèles prédictifs basés sur des données biologiques et chimiques.

Techniques de chimie combinatoire - Informations médicales vérifiées

Depression circuit adaptation in post-stroke depression.

01 09 2023

DOI: 10.1016/j.jad.2023.05.016 PMID: 37201899

Lesion locations of post-stroke depression (PSD) mapped to a depression circuit which centered by the left dorsolateral prefrontal cortex (DLPFC). However, it remains unknown whether the compensatory ... Rs-fMRI data were collected from 82 non-depressed stroke patients (Stroke), 39 PSD patients and 74 healthy controls (HC). We tested the existence of depression circuit, examined PSD-related alteration... We found that: 1) the left DLPFC showed significantly stronger connectivity to lesions of PSD than Stroke group; 2) in comparison to both Stroke and HC groups, PSD exhibited increased connectivity wit... Longitudinal studies are required to explore the alterations of depression circuit in PSD as the disease progress.... PSD underwent specific alterations in depression circuit, which may help to establish objective imaging markers for early diagnosis and interventions of the disease....

Humans Depression Stroke Transcranial Magnetic Stimulation Prefrontal Cortex +2 autres

Dissecting the depressed mood criterion in adult depression: The heterogeneity of mood disturbances in major depressive episodes.

15 02 2023

DOI: 10.1016/j.jad.2022.11.047 PMID: 36455714

Mood disturbances have historically remained a core criterion in diagnosing major depressive episode. DSMs have illustrated this criterion with depressed, hopeless, discouraged, cheerless, and irritab... The current study used a nationally representative sample of U.S. adults with unipolar major depressive disorder to study the association between specific forms of mood disturbances to depression seve... Cheerless and hopeless mood were associated with depression severity. Hopeless and irritable mood were associated with depression chronicity. Different forms of mood disturbance showed differential re... The relations between different forms of mood disturbances and various aspects of depression are nuanced. Theoretically, these relations highlight the potential utility in acknowledging the complexity...

Adult Humans Depressive Disorder, Major Depression Mood Disorders +3 autres

Rethinking treatment-resistant depression to quasi-tenacious depression.

12 01 2023

DOI: 10.1192/j.eurpsy.2022.2353 PMID: 36632817

With almost one-third of patients with major depression not adequately responsive to treatments, the management of treatment-resistant depression (TRD) has continued to be challenging. Recently, an es...

Humans Depression Quality of Life Depressive Disorder, Major Depressive Disorder, Treatment-Resistant

Viewpoint: Difficult-to-treat depression versus treatment-resistant depression: A new integrative perspective for managing depression.

08 09 2023

DOI: 10.1192/j.eurpsy.2023.2448 PMID: 37680180

In the STAR*D study, the efficacy of treatments for major depression was examined. It was found that, while many responded to the initial antidepressant treatment, only 30% of participants achieved co...

Humans Depression Antidepressive Agents Psychotherapy Depressive Disorder, Major +1 autres

Innate depression.

23 08 2022

DOI: 10.1126/scisignal.ade4885 PMID: 35998233

Restoring AHI1 in macrophages may improve antiviral immunity in patients with depression....

Depression Humans Immunity, Innate Macrophages

Overview of Depression.

Feb 2024

DOI: 10.1016/j.emc.2023.06.013 PMID: 37977742

Depressive disorders encompass a spectrum of diagnoses and are more common in women and transgender individuals. Diagnosis involves thorough history-taking and exclusion of underlying medical disorder...

Humans Female Depression Self-Injurious Behavior

Depression in transplantation.

01 12 2022

DOI: 10.1097/MOT.0000000000001024 PMID: 36227755

To review and summarize the literature published between 1 January 2020 and 30 June 2022, on the prevalence, risk factors and impact of depression in transplant population.... Depression is common in transplantation candidates and recipients, with a prevalence up to 85.8% in kidney recipients. Multiple studies have indicated after transplantation depression correlates with ... Depression is a common finding in transplant population. More research is needed to understand the biological substrate and risk factors and to develop effective treatment interventions....

Humans Depression Transplant Recipients Organ Transplantation Kidney Transplantation +1 autres

Coping with depression: a narrative study of an online depression community in China.

Dec 2023

DOI: 10.1080/17482631.2023.2268379 PMID: 37847860

The goal of this study was to explore the coping strategies of depression sufferers that have worked for them based on the study of an online depression community.... We conducted a thematic narrative analysis of 120 stories posted by the members in the largest online depression community in China. MaxQDA version 18 was used to code the data, and the analytic appro... The study found that the coping strategies mainly include self-reconciliation (e.g., perceiving/accepting feelings, accepting the present self, and holding hope for the future), actions (recreational ... The findings revealed the coping strategies that were helpful and examined how they functioned for the affected members, which make up for the lack of attention to the individual experiences of depres...

Humans Depression Adaptation, Psychological Social Support China +1 autres

Baseline depression severity as moderator on depression outcomes in psychotherapy and pharmacotherapy.

01 01 2024

DOI: 10.1016/j.jad.2023.10.047 PMID: 37820960

Evidence-based treatments for adult depression include psychotherapy and pharmacotherapy, yet little is known about how baseline depression severity moderates treatment outcome.... We aimed to compare the effects of psychotherapy and pharmacotherapy for adult depression and to examine the association between baseline depression severity and treatment outcome, converting multiple... We conducted systematic searches in bibliographical databases up to September 2022 to identify randomized controlled trials (RCTs) in which psychotherapy was compared with pharmacotherapy in the treat... We identified 65 RCTs including 7250 participants for the meta-analyses and 56 RCTs including 5548 participants for the meta-regression. We found no significant difference between psychotherapy and ph... Limitations included the low quality of the included studies, and the omission of long-term effects and within-study variability.... We found no indication for a moderation effect of baseline depression severity on the relative effects of psychotherapy and pharmacotherapy. Thus, other factors such as availability and patients' pref...

Adult Humans Depression Antidepressive Agents Psychotherapy +2 autres

Understanding Perceptions of Depression and Depression Care across Culture and Context.

17 09 2022

DOI: 10.3390/ijerph191811720 PMID: 36141992

Depression is a leading cause of disability, affecting approximately 300 million people globally [...]....

Depression Disabled Persons Humans

Techniques de chimie combinatoire : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 2

Symptômes 2

Prévention 2

Traitements 2

Complications 2

Facteurs de risque 2

Contenu validé par Dr Olivier Menir

Sous-catégories

Technique SELEX

Auteurs principaux

Sources (10000 au total)