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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction de cdc42 ?",
"position": 1,
"acceptedAnswer": {
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"text": "Des tests génétiques et des analyses de signalisation cellulaire peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour cdc42 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent l'immunoblotting et la microscopie à fluorescence."
}
},
{
"@type": "Question",
"name": "Y a-t-il des biomarqueurs pour cdc42 ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de biomarqueurs spécifiques pour cdc42."
}
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{
"@type": "Question",
"name": "Quels symptômes indiquent un problème avec cdc42 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la migration cellulaire et la morphogenèse peuvent être observées."
}
},
{
"@type": "Question",
"name": "Peut-on détecter cdc42 dans des échantillons biologiques ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, cdc42 peut être détecté dans des échantillons de tissus ou de cellules."
}
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{
"@type": "Question",
"name": "Quels sont les symptômes d'une mutation de cdc42 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les mutations peuvent entraîner des troubles de la migration cellulaire et des malformations."
}
},
{
"@type": "Question",
"name": "Comment cdc42 affecte-t-il la cellule ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cdc42 régule la forme et le mouvement des cellules, influençant leur fonction."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes cliniques associés à cdc42 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans le développement et la motilité cellulaire peuvent être observées."
}
},
{
"@type": "Question",
"name": "Cdc42 est-il lié à des maladies spécifiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies de cdc42 sont associées à des cancers et des maladies génétiques."
}
},
{
"@type": "Question",
"name": "Quels effets cdc42 a-t-il sur le cytosquelette ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cdc42 joue un rôle clé dans la régulation du cytosquelette, influençant la forme cellulaire."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les mutations de cdc42 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention des mutations génétiques est complexe et dépend de facteurs environnementaux."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives pour les maladies liées à cdc42 ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des conseils génétiques peuvent aider à évaluer le risque de maladies liées à cdc42."
}
},
{
"@type": "Question",
"name": "Comment le mode de vie influence-t-il cdc42 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain peut réduire le risque de maladies associées à cdc42."
}
},
{
"@type": "Question",
"name": "Les tests génétiques peuvent-ils prévenir des problèmes avec cdc42 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les porteurs de mutations de cdc42."
}
},
{
"@type": "Question",
"name": "Y a-t-il des recommandations diététiques pour cdc42 ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut soutenir la santé cellulaire, mais n'affecte pas directement cdc42."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent cdc42 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques de cdc42 sont en cours de développement pour le cancer."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des thérapies géniques pour cdc42 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est une approche potentielle pour corriger les mutations de cdc42."
}
},
{
"@type": "Question",
"name": "Y a-t-il des médicaments pour moduler cdc42 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des composés chimiques sont en cours d'évaluation pour moduler l'activité de cdc42."
}
},
{
"@type": "Question",
"name": "Comment la recherche avance-t-elle sur cdc42 ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La recherche se concentre sur les inhibiteurs et les voies de signalisation associées."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils efficaces contre cdc42 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité des traitements dépend du type de maladie et de la mutation spécifique."
}
},
{
"@type": "Question",
"name": "Quelles complications sont liées à cdc42 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles du développement et des cancers."
}
},
{
"@type": "Question",
"name": "Cdc42 peut-il entraîner des problèmes neurologiques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies de cdc42 sont associées à des troubles neurologiques dans certains cas."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications à long terme avec cdc42 ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications à long terme peuvent inclure des cancers et des malformations congénitales."
}
},
{
"@type": "Question",
"name": "Comment cdc42 affecte-t-il le système immunitaire ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cdc42 peut influencer la réponse immunitaire, mais les effets varient selon les contextes."
}
},
{
"@type": "Question",
"name": "Les complications de cdc42 sont-elles réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour cdc42 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques et des influences environnementales."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines affecte-t-elle cdc42 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines toxines environnementales peuvent influencer l'expression de cdc42."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux augmentent-ils le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies génétiques peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter cdc42 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress peut influencer la signalisation cellulaire, y compris celle de cdc42."
}
},
{
"@type": "Question",
"name": "Y a-t-il des groupes à risque pour cdc42 ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les individus avec des mutations génétiques spécifiques sont à risque accru."
}
}
]
}
]
}
Despite limited sensitivity, the gold standard for the diagnosis of malignant cells in ascites is still cytology. The aim of this prospective proof-of-principle study was to evaluate DNA methylation a...
A cohort of 79 patients with malignant and non-malignant ascites was prospectively enrolled. Ascites was assessed by cytopathological and laboratory examination. Cell pellets obtained by centrifugatio...
Methylation status of studied LINE-1 and microRNA-137 could be reliably detected in all samples. Systematic evaluation revealed reliable reproducibility with satisfactory short- and long-term stabilit...
Analysis of DNA methylation in ascites is technically feasible, well reproducible and may lead to identification of potential biomarkers for peritoneal carcinomatosis and other conditions. Inflammator...
Peritoneal surface malignancies (PSMs) are usually associated with a poor prognosis. Nonetheless, in line with advances in the management of most abdominopelvic metastatic diseases, considerable progr...
Differential diagnosis between tuberculous peritonitis and peritoneal carcinomatosis remains challenging in clinical practice; thus, in-patients diagnosed with tuberculous peritonitis or peritoneal ca...
Consecutive patients diagnosed with tuberculous peritonitis or peritoneal carcinomatosis were retrospectively enrolled. The pertinent data of 169 patients enrolled were collected....
A panel of ascitic tumor makers (CEA, CA15-3, CA19-9) had high specificity (96.83%) and accuracy (94.67%) in the differentiation of peritoneal carcinomatosis from tuberculous peritonitis; and ascitic ...
Combined use of ascitic tumor markers and adenosine deaminase showed excellent efficiency in the differential diagnosis between tuberculous peritonitis and peritoneal carcinomatosis, thus these two si...
Although intraoperative peritoneal lavage often is performed routinely with the aim of reducing peritoneal contamination, evidence of lavage benefit in elective pancreatic surgery is limited....
We retrospectively classified patients who had undergone pancreatic surgery to groups given or not given peritoneal lavage, then comparing clinical results. This saline lavage was performed at the end...
Among all 104 patients in the study, incidence of infectious complications in the lavage group (n = 65) was significantly higher than in the non-lavage group (n = 39; 35% vs. 15%, P = 0.041), while in...
Intraoperative lavage did not prevent surgical site infection or peritoneal recurrence of pancreatobiliary cancer....
It is still a challenge to make early differentiation of peritoneal tuberculosis (PTB) and peritoneal carcinomatosis (PC) clinically as well as on imaging and laboratory tests. We aimed to develop a m...
This retrospective study included 88 PTB patients and 90 PC patients (training cohort: 68 PTB patients and 69 PC patients from Beijing Chest Hospital; testing cohort: 20 PTB patients and 21 PC patient...
There were significant differences in the following aspects between the two groups: (1) age; (2) fever; (3) night sweat; (4) cake-like thickening of the omentum and omental rim (OR) sign; (5) irregula...
The model has the potential to distinguish PTB from PC and thus has the potential to be a diagnostic tool....
Selected patients with peritoneal metastases of colorectal cancer (PM-CRC) can benefit from potentially curative cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC), with a...
The aims of this evidence-based consensus were to define the indications for HIPEC, to select the preferred HIPEC regimens, and to define research priorities regarding the use of HIPEC for PM-CRC....
The consensus steering committee elaborated and formulated pertinent clinical questions according to the PICO (patient, intervention, comparator, outcome) method and assessed the evidence according to...
Evidence was weak or very weak for 9/10 clinical questions. In total, 70/90 eligible panelists replied to both Delphi rounds (78%), with a consensus for 10/10 questions on HIPEC regimens. There was st...
Based on the available evidence, despite the negative results of PRODIGE 7, HIPEC could be conditionally recommended to patients with PM-CRC after CRS. While more preclinical and clinical data are eag...
Recurrence after curative-intent pancreatectomy for pancreatic ductal adenocarcinomas (PDAC) is quite frequent with locoregional and peritoneal recurrence in about one-third of cases. We hypothesize t...
Under institutional review board (IRB)-approved protocol, pre- and postresection PL fluids were collected from PDAC patients undergoing curative-intent pancreatectomy. PL fluids from PDAC patients wit...
KRAS-mutant ptDNA was detected in PL fluids from all PDAC patients. KRAS-mutant ptDNA was detected in 11/21 (52%) preresection and 15/18 (83%) postresection PL fluid samples. With a median follow-up o...
This study suggests that ptDNA in postresection PL fluids may be a useful biomarker to predict locoregional and peritoneal recurrence in resected PDAC patients....
The Peritoneal Regression Grading Score (PRGS) is a 4-tied histologic regression grading score for determining the response of peritoneal metastasis to chemotherapy. Peritoneal biopsies in every abdom...
A total of 339 biopsies obtained during 76 laparoscopies in 33 patients with peritoneal metastasis of gastric cancer were analyzed. Biopsies classified as PRGS 1 (no residual tumor, n=95) or indefinit...
After PAS-staining tumor cells were detected in 28 out of 145 biopsies (19%), the remaining 117 biopsies were immunostained with Ber-EP4. Tumor cells were detected in 22 biopsies (19%). In total, addi...
In summary, 25% (24 out of 95) of initially tumor-free samples (PRGS1) showed residual tumor cells after additional staining with PAS and/or BerEp4. Immunohistochemistry provided important additional ...
Gastric adenocarcinoma, commonly known as stomach cancer, has a predilection for metastasis to the peritoneum, which portends limited survival. The peritoneal metastatic cascade remains poorly underst...
Cotyledonoid dissecting leiomyoma (CDL) is a rare benign uterine leiomyoma that macroscopically shows multinodular placenta-like growth. Its border with the myometrial layer is unclear, making it clin...