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"@type": "Question",
"name": "Comment diagnostique-t-on la paralysie pseudobulbaire ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'examen clinique et l'évaluation des symptômes neurologiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
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"text": "Des tests d'imagerie cérébrale comme l'IRM peuvent être utilisés pour identifier les lésions."
}
},
{
"@type": "Question",
"name": "Quels symptômes aident au diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des accès de rire ou de pleurs inappropriés et des troubles de la parole."
}
},
{
"@type": "Question",
"name": "La paralysie pseudobulbaire est-elle toujours associée à d'autres maladies ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est souvent associée à des maladies neurologiques comme la sclérose en plaques ou les AVC."
}
},
{
"@type": "Question",
"name": "Peut-on confondre cette paralysie avec d'autres troubles ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut être confondue avec d'autres troubles affectant le contrôle émotionnel et moteur."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux symptômes de la paralysie pseudobulbaire ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les principaux symptômes incluent des crises de rire ou de pleurs incontrôlables."
}
},
{
"@type": "Question",
"name": "La difficulté à parler est-elle un symptôme courant ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients peuvent éprouver des difficultés à articuler et à contrôler leur voix."
}
},
{
"@type": "Question",
"name": "Les patients ressentent-ils de la douleur ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "La paralysie pseudobulbaire ne cause généralement pas de douleur physique, mais des malaises émotionnels."
}
},
{
"@type": "Question",
"name": "Y a-t-il des variations dans les symptômes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier en intensité et en fréquence d'un patient à l'autre."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils s'aggraver avec le temps ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, sans traitement, les symptômes peuvent s'aggraver et affecter la qualité de vie."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la paralysie pseudobulbaire ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention spécifique, mais la gestion des maladies sous-jacentes peut aider."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque de paralysie pseudobulbaire ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Adopter un mode de vie sain et traiter les affections neurologiques peut réduire le risque."
}
},
{
"@type": "Question",
"name": "Les AVC peuvent-ils être prévenus ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, en contrôlant les facteurs de risque comme l'hypertension et le diabète, on peut réduire les AVC."
}
},
{
"@type": "Question",
"name": "La réhabilitation précoce aide-t-elle à prévenir la paralysie ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une réhabilitation précoce après un AVC ou une lésion cérébrale peut aider à prévenir la paralysie."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles le risque ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut contribuer à la santé neurologique et réduire les risques."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour la paralysie pseudobulbaire ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments comme les antidépresseurs et la thérapie comportementale."
}
},
{
"@type": "Question",
"name": "La rééducation est-elle utile ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la rééducation orthophonique peut aider à améliorer les capacités de communication."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils réduire les symptômes ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent réduire la fréquence et l'intensité des épisodes émotionnels."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements non médicamenteux ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des approches comme la thérapie psychologique peuvent également être bénéfiques."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils efficaces pour tous les patients ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité des traitements peut varier selon les individus et la gravité des symptômes."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la paralysie pseudobulbaire ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles de la déglutition et des problèmes de communication."
}
},
{
"@type": "Question",
"name": "La dépression est-elle une complication fréquente ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients peuvent développer une dépression en raison de l'impact émotionnel de la maladie."
}
},
{
"@type": "Question",
"name": "Les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent significativement altérer la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques d'isolement social ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les difficultés de communication peuvent entraîner un isolement social pour les patients."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être traitées ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées avec des traitements appropriés et un soutien."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les AVC, les maladies neurodégénératives et les traumatismes crâniens sont des facteurs de risque."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de paralysie pseudobulbaire ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente avec l'âge, surtout chez les personnes âgées ayant des antécédents médicaux."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies neurologiques peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Le mode de vie peut-il influencer le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les maladies cardiovasculaires augmentent le risque de paralysie pseudobulbaire par AVC."
}
}
]
}
]
}
From the Departments of Pediatrics and Neurology/Neurosurgery, McGill University; and Division of Pediatric Neurology, Montreal Children's Hospital-McGill University Health Centre, Canada. michael.shevell@muhc.mcgill.ca.
Division of Occupational Therapy and Physical Therapy, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 4007, Cincinnati, OH 45229, USA.
Faculty of Medicine (JPL), McGill University, Montreal, QC; Department of Pediatrics and Neurology and Neurosurgery (MO, MS), McGill University, Montreal, QC; Centre for Outcomes Research and Evaluation (MO, PN, MS), Research Institute of the McGill University Health Centre, Montreal, QC; Department of Pediatrics (JA), University of Alberta, Edmonton, AB; Janeway Children's Hospital (DB), St. John's, NL; Department of Paediatrics (DF), University of Toronto, Bloorview Research Institute, Toronto, ON; Departments of Pediatrics and Clinical Neurosciences (AK), Cumming School of Medicine, University of Calgary, AB; Centre de réadaptation Marie Enfant du CHU Sainte-Justine (LK), Montreal, QC; Centre hospitalier universitaire de Sherbrooke (NP), Sherbrooke, QC; BC Children's Hospital (EvR), Vancouver, BC; and IWK Health Centre (EW), Halifax, NS, Canada.
Clinical Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM, Tianjin 300380, China; National Clinical Research Center for Acupuncture and Moxibustion of Chinese Medicine, Tianjin 300380.
Clinical Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM, Tianjin 300380, China; National Clinical Research Center for Acupuncture and Moxibustion of Chinese Medicine, Tianjin 300380.
Clinical Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM, Tianjin 300380, China; National Clinical Research Center for Acupuncture and Moxibustion of Chinese Medicine, Tianjin 300380.
Clinical Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM, Tianjin 300380, China; National Clinical Research Center for Acupuncture and Moxibustion of Chinese Medicine, Tianjin 300380.
The complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted proces...
The complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in monitoring both di...
We performed a systematic analysis of the current methods used to assess complement components and reviewed whether the identified studies performed their complement measurements according to the reco...
A literature search using the Pubmed/MEDLINE database was performed focusing on studies measuring the key complement components C3, C5 and/or their split products and/or the soluble variant of the ter...
A total of 92 out of 376 studies were selected for full-text analysis. Forty-five studies (49%) were identified as using the correct sample type and techniques for their complement analyses, while 25 ...
A substantial part of the reviewed studies did not use the appropriate sample type for assessing complement activation or did not mention which sample type was used. This deviation from the standardiz...
Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system. Regardless, in IgG4 related disease (IgG4-RD)...
Although kidney transplantation is the best treatment for end stage kidney disease, the benefits are limited by factors such as the short fall in donor numbers, the burden of immunosuppression and gra...
Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported. The ...
First, we used bioinformatics and functional enrichment to screen and identify the urine protein profile of SLE patients. Then, analyzed and verified the proteins related to the complement pathway by ...
A total of 14 complement pathway-related proteins were screened for differences in expression between the active group and the stable group, eight of these DEPs were up-regulated and six were down-reg...
Complement-related DEPs in urine have a certain correlation with SLE disease activity. Urine C9, C8A, C4B and C8G present promising non-invasive biomarkers for monitoring lupus activity....
Vaginal microbiome and the local innate immune defense, including the complement system, contribute to anti- and proinflammatory homeostasis during pregnancy and parturition. The relationship between ...
To study the association of the cervicovaginal microbiota composition to activation and regulation of the complement system during pregnancy and labor....
We recruited women during late pregnancy (weeks 41 + 5 to 42 + 0, n=48) and women in active labor (weeks 38 + 4 to 42 + 2, n=25). Mucosal swabs were taken from the external cervix and lateral fornix o...
The vaginal microbiota was...
These results indicate that bacterial composition of the vaginal microbiota could have a role in the local activation and regulation of complement-mediated inflammation during pregnancy. At the time o...
Histopathologic studies have identified immunoglobulin (Ig) deposition and complement activation as contributors of CNS tissue damage in multiple sclerosis (MS). Intrathecal IgM synthesis is associate...
CC and CAP levels were quantified in plasma and CSF of 112 patients with clinically isolated syndrome (CIS), 127 patients with MS (90 relapsing-remitting, 14 primary progressive, and 23 secondary prog...
CSF (but not plasma) levels of C3a, C4a, Ba, and Bb were increased in patients with CIS/MS, being most pronounced in those with an additional intrathecal IgM production. In CIS, doubling of C3a and C4...
CNS-compartmentalized activation of the classical and alternative pathways of complement is increased in CIS/MS and associated with the presence of an intrathecal IgM production. Increased complement ...
Several studies have shown the importance of the complement and coagulation systems in the pathogenesis of asthma....
We explored whether we could detect differentially abundant complement and coagulation proteins in the samples obtained from the small airway lining fluid by collection of exhaled particles in patient...
Exhaled particles were obtained from 20 subjects with asthma and 10 healthy controls (HC) with the PExA method and analysed with the SOMAscan proteomics platform. Lung function was assessed by nitroge...
53 proteins associated with the complement and coagulation systems were included in the analysis. Nine of those proteins were differentially abundant in subjects with asthma as compared to HC, and C3 ...
The study highlights the role of the local activation of the complement and coagulation systems in the small airway lining fluid in asthma and their association with both asthma control and small airw...
Malignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP). However, the mechanism underlying local AP activation is...