questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines membranaires
Protéines de transport membranaire
Transporteurs nucléocytoplasmiques
Transporteurs nucléocytoplasmiques : Questions médicales fréquentes
Termes MeSH sélectionnés :
Angiotensin II Type 2 Receptor Blockers
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des transporteurs nucléocytoplasmiques ?",
"position": 1,
"acceptedAnswer": {
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"text": "Des tests génétiques et des analyses de protéines peuvent être utilisés pour diagnostiquer."
}
},
{
"@type": "Question",
"name": "Quels examens sont recommandés pour évaluer ces transporteurs ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'immunohistochimie et la microscopie électronique sont souvent utilisés."
}
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"@type": "Question",
"name": "Quels marqueurs biologiques sont associés aux transporteurs ?",
"position": 3,
"acceptedAnswer": {
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"text": "Des biomarqueurs comme les protéines Ran et karyophérines sont souvent étudiés."
}
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"@type": "Question",
"name": "Peut-on utiliser l'imagerie pour évaluer ces transporteurs ?",
"position": 4,
"acceptedAnswer": {
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"text": "Oui, l'imagerie par résonance magnétique peut aider à visualiser les anomalies."
}
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{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème de transporteurs ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes neurologiques ou des troubles métaboliques peuvent survenir."
}
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{
"@type": "Question",
"name": "Quels symptômes sont liés à une défaillance des transporteurs ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, troubles cognitifs et anomalies cellulaires peuvent être observés."
}
},
{
"@type": "Question",
"name": "Les troubles de la motricité sont-ils associés aux transporteurs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles moteurs peuvent survenir en raison de dysfonctionnements."
}
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{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques aux maladies génétiques ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes variés comme des malformations congénitales peuvent apparaître."
}
},
{
"@type": "Question",
"name": "Comment les symptômes varient-ils selon les types de transporteurs ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent varier selon le type de protéine et le tissu affecté."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils être réversibles ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas, une intervention précoce peut améliorer les symptômes."
}
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{
"@type": "Question",
"name": "Comment prévenir les dysfonctionnements des transporteurs ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être recommandés pour les familles à risque."
}
},
{
"@type": "Question",
"name": "Les vaccinations peuvent-elles jouer un rôle ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent prévenir des infections qui affectent les transporteurs."
}
},
{
"@type": "Question",
"name": "Comment le stress influence-t-il ces transporteurs ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut altérer la fonction des transporteurs nucléocytoplasmiques."
}
},
{
"@type": "Question",
"name": "L'éducation à la santé est-elle importante ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'éducation à la santé peut sensibiliser aux risques et aux préventions."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les dysfonctionnements ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements peuvent inclure des thérapies géniques et des médicaments ciblés."
}
},
{
"@type": "Question",
"name": "Les suppléments nutritionnels peuvent-ils aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains suppléments peuvent soutenir la fonction cellulaire et métabolique."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux en cours ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des essais cliniques sur des thérapies innovantes sont en cours pour ces troubles."
}
},
{
"@type": "Question",
"name": "Comment la réhabilitation peut-elle aider ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La réhabilitation peut améliorer la fonction physique et cognitive des patients."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec ces dysfonctionnements ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications neurologiques et métaboliques peuvent se développer."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles liées ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines maladies auto-immunes peuvent être exacerbées par ces dysfonctionnements."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études suggèrent un lien entre dysfonctionnements et risque accru de cancer."
}
},
{
"@type": "Question",
"name": "Comment ces complications affectent-elles la qualité de vie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent réduire la qualité de vie en affectant la mobilité et la cognition."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés aux dysfonctionnements ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent jouer un rôle."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la fonction des transporteurs nucléocytoplasmiques."
}
},
{
"@type": "Question",
"name": "Le mode de vie sédentaire influence-t-il ces transporteurs ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sédentaire peut contribuer à des dysfonctionnements cellulaires."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques augmentent-elles les risques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies chroniques comme le diabète peuvent affecter la fonction des transporteurs."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut nuire à la santé cellulaire et affecter les transporteurs."
}
}
]
}
]
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Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these medications might impact th...
In a post-hoc subgroup analysis of the randomized, placebo-controlled, Angiotensin Therapy for High Output Shock (ATHOS-3) trial, we compared patients with chronic angiotensin-converting enzyme inhibi...
We included n = 321 patients, of whom, 270 were ACEi and ARB-unexposed, 29 were ACEi-exposed and 22 ARB-exposed. In ACEi/ARB-unexposed patients, angiotensin-treated patients, compared to placebo, had ...
In vasodilatory shock patients, the cardiovascular and biological RAS response to angiotensin-II differed based upon prior exposure to ACEi and ARB medications. ACEi-exposure was associated with incre...
Although guidelines recommend the use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) in patients with diabetes, hypertension, and albuminuria, their use r...
This retrospective cross-sectional study was conducted using data from the Hatyai Hospital database. Adult patients with diabetes, hypertension, and albuminuria were included. Clinical data and labora...
Of 4,655 eligible patients, 500 patients were selected. The average age of the patients was 66.3 years, and 59.6% were female. The adherence rate was 72.4%. Multivariate logistic regression analysis f...
ACEi/ARB therapy was suboptimal in patients with diabetes, hypertension, and albuminuria. Non-adherence was associated with CKD stage, possibly because of concerns about adverse events and healthcare-...
Cardiovascular diseases (CVDs) have a high mortality rate, and despite the several available therapeutic targets, non-response to antihypertensives remains a common problem. Angiotensin-converting enz...
The renin-angiotensin-aldosterone system (RAAS) is a major target for treating hypertension and preventing various complications. Mineralocorticoid receptor (MR) antagonists are recommended as specifi...
Angiotensin II receptor blockers (ARBs) are contraindicated during pregnancy because of fetal toxicity. All previous reports on adverse fetal outcomes involved women who continued to take low-dose ARB...
Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers are widely used to reduce high blood pressure or in other conditions such as congestive heart failure and prevention of di...
Bradykinin angioedemas are a potentially serious side effect of angiotensin-converting enzyme inhibitors (ACEI) and more controversially of angiotensin II receptor blockers (ARB). Their challenging di...
The aim of this study was to determine the prevalence of recurrent angioedema in patients referred for ACEI/ARB-induced bradykinin angioedema, after more than 6 months of drug discontinuation....
We included ACEI/ARB-treated patients referred for angioedema(s) without hives and unresponsive to antihistamines, after they discontinued ACEI/ARB for at least 6 months. Any C1-inhibitor deficiency w...
Thirty-eight of 93 patients (41%) with a suspicion of ACEI/ARB-induced bradykinin angioedema still had recurrent angioedema (n = 27) or developed hives (n = 2) or both (n = 9) after 6 months of drug d...
In patients referred for acquired angioedema without wheals occurring during ACEI/ARB therapy, 59% finally had a diagnosis of ACEI/ARB-induced bradykinin angioedema whereas 41% were rather diagnosed w...
The angiotensin II type 2 receptor (AT2R) exerts vasorelaxant, anti-inflammatory, and antioxidant properties. In obesity, its activation counterbalances the adverse cardiovascular effects of angiotens...
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug de...
Angiotensin receptor blockers (ARBs) may slow down the progression of aortic stenosis (AS), through their antifibrotic effect. Females present more valvular fibrosis than males, thus ARBs may have mor...
We included patients who had an aortic valve replacement± coronary bypass grafting between 2006-2013. Patients with missing echocardiographic or histologic data were excluded. Warren-Yong and fibrosis...
Among the 1,321 included patients, the vast majority (89%) has severe AS. Patients in the predominant fibrosis group, as compared to the predominant calcium group, were more often females (39 vs 31%, ...
In this large series of patients with moderate-severe AS, among females there was a negative association between intake of ARBs and valvular fibrosis. Thus, the possible effects of ARBs may be sex-spe...