Titre : Transporteurs nucléocytoplasmiques

Transporteurs nucléocytoplasmiques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Colorectal Neoplasms
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"https://questionsmedicales.fr/mesh/D029543?mesh_terms=Colorectal+Neoplasms&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Transporteurs nucléocytoplasmiques", "description": "Quels symptômes sont liés à une défaillance des transporteurs ?\nLes troubles de la motricité sont-ils associés aux transporteurs ?\nY a-t-il des symptômes spécifiques aux maladies génétiques ?\nComment les symptômes varient-ils selon les types de transporteurs ?\nLes symptômes peuvent-ils être réversibles ?", "url": "https://questionsmedicales.fr/mesh/D029543?mesh_terms=Colorectal+Neoplasms&page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Transporteurs nucléocytoplasmiques", "description": "Comment prévenir les dysfonctionnements des transporteurs ?\nY a-t-il des tests de dépistage recommandés ?\nLes vaccinations peuvent-elles jouer un rôle ?\nComment le stress influence-t-il ces transporteurs ?\nL'éducation à la santé est-elle importante ?", "url": "https://questionsmedicales.fr/mesh/D029543?mesh_terms=Colorectal+Neoplasms&page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Transporteurs nucléocytoplasmiques", "description": "Quels traitements sont disponibles pour les dysfonctionnements ?\nLes suppléments nutritionnels peuvent-ils aider ?\nY a-t-il des traitements expérimentaux en cours ?\nComment la réhabilitation peut-elle aider ?\nLes traitements sont-ils personnalisés ?", "url": "https://questionsmedicales.fr/mesh/D029543?mesh_terms=Colorectal+Neoplasms&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Transporteurs nucléocytoplasmiques", "description": "Quelles complications peuvent survenir avec ces dysfonctionnements ?\nLes maladies auto-immunes sont-elles liées ?\nY a-t-il un risque accru de cancer ?\nComment ces complications affectent-elles la qualité de vie ?\nLes complications sont-elles réversibles ?", "url": "https://questionsmedicales.fr/mesh/D029543?mesh_terms=Colorectal+Neoplasms&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Transporteurs nucléocytoplasmiques", "description": "Quels facteurs de risque sont associés aux dysfonctionnements ?\nL'âge est-il un facteur de risque ?\nLe mode de vie sédentaire influence-t-il ces transporteurs ?\nLes maladies chroniques augmentent-elles les risques ?\nLe tabagisme est-il un facteur de risque ?", "url": "https://questionsmedicales.fr/mesh/D029543?mesh_terms=Colorectal+Neoplasms&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des transporteurs nucléocytoplasmiques ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses de protéines peuvent être utilisés pour diagnostiquer." } }, { "@type": "Question", "name": "Quels examens sont recommandés pour évaluer ces transporteurs ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "L'immunohistochimie et la microscopie électronique sont souvent utilisés." } }, { "@type": "Question", "name": "Quels marqueurs biologiques sont associés aux transporteurs ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des biomarqueurs comme les protéines Ran et karyophérines sont souvent étudiés." } }, { "@type": "Question", "name": "Peut-on utiliser l'imagerie pour évaluer ces transporteurs ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'imagerie par résonance magnétique peut aider à visualiser les anomalies." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème de transporteurs ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes neurologiques ou des troubles métaboliques peuvent survenir." } }, { "@type": "Question", "name": "Quels symptômes sont liés à une défaillance des transporteurs ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, troubles cognitifs et anomalies cellulaires peuvent être observés." } }, { "@type": "Question", "name": "Les troubles de la motricité sont-ils associés aux transporteurs ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles moteurs peuvent survenir en raison de dysfonctionnements." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux maladies génétiques ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes variés comme des malformations congénitales peuvent apparaître." } }, { "@type": "Question", "name": "Comment les symptômes varient-ils selon les types de transporteurs ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent varier selon le type de protéine et le tissu affecté." } }, { "@type": "Question", "name": "Les symptômes peuvent-ils être réversibles ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Dans certains cas, une intervention précoce peut améliorer les symptômes." } }, { "@type": "Question", "name": "Comment prévenir les dysfonctionnements des transporteurs ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir." } }, { "@type": "Question", "name": "Y a-t-il des tests de dépistage recommandés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques peuvent être recommandés pour les familles à risque." } }, { "@type": "Question", "name": "Les vaccinations peuvent-elles jouer un rôle ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Certaines vaccinations peuvent prévenir des infections qui affectent les transporteurs." } }, { "@type": "Question", "name": "Comment le stress influence-t-il ces transporteurs ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Le stress chronique peut altérer la fonction des transporteurs nucléocytoplasmiques." } }, { "@type": "Question", "name": "L'éducation à la santé est-elle importante ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'éducation à la santé peut sensibiliser aux risques et aux préventions." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les dysfonctionnements ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements peuvent inclure des thérapies géniques et des médicaments ciblés." } }, { "@type": "Question", "name": "Les suppléments nutritionnels peuvent-ils aider ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains suppléments peuvent soutenir la fonction cellulaire et métabolique." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux en cours ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des essais cliniques sur des thérapies innovantes sont en cours pour ces troubles." } }, { "@type": "Question", "name": "Comment la réhabilitation peut-elle aider ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "La réhabilitation peut améliorer la fonction physique et cognitive des patients." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec ces dysfonctionnements ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications neurologiques et métaboliques peuvent se développer." } }, { "@type": "Question", "name": "Les maladies auto-immunes sont-elles liées ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines maladies auto-immunes peuvent être exacerbées par ces dysfonctionnements." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Des études suggèrent un lien entre dysfonctionnements et risque accru de cancer." } }, { "@type": "Question", "name": "Comment ces complications affectent-elles la qualité de vie ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Elles peuvent réduire la qualité de vie en affectant la mobilité et la cognition." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes." } }, { "@type": "Question", "name": "Quels facteurs de risque sont associés aux dysfonctionnements ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent jouer un rôle." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement peut affecter la fonction des transporteurs nucléocytoplasmiques." } }, { "@type": "Question", "name": "Le mode de vie sédentaire influence-t-il ces transporteurs ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Un mode de vie sédentaire peut contribuer à des dysfonctionnements cellulaires." } }, { "@type": "Question", "name": "Les maladies chroniques augmentent-elles les risques ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies chroniques comme le diabète peuvent affecter la fonction des transporteurs." } }, { "@type": "Question", "name": "Le tabagisme est-il un facteur de risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut nuire à la santé cellulaire et affecter les transporteurs." } } ] } ] }

Sources (10000 au total)

Risk and preventive factors of early-onset colorectal neoplasms: endoscopic and histological database analysis.

The incidence of early-onset colorectal neoplasms has been increasing in both Western and Eastern countries. However, the risks and preventive factors for these neoplasms in Eastern countries remain u... The data of 5580 patients who underwent colonoscopy between 2016 and 2021 were retrospectively evaluated. The primary outcome was advanced colorectal neoplasm (ACRN), defined as advanced adenomas (ade... Among 1001 patients (age ≤50 years), ACRN was found in 94 (9.4%). In this younger category, male sex (adjusted odds ratio [aOR]:2.34, 95% confidence interval [CI]:1.51-3.63) and a family history of co... The development of early-onset ACRNs was primarily associated with congenital factors, whereas that of late-onset ACRNs was associated with acquired ones. Colonoscopy is recommended for young male pat...

Tip-in EMR as an alternative to endoscopic submucosal dissection for 20- to 30-mm nonpedunculated colorectal neoplasms.

Tip-in EMR, which includes anchoring the snare tip, has recently shown a favorable en-bloc and R0 resection rate for colorectal neoplasms. Thus, Tip-in EMR may be an alternative to endoscopic submucos... This retrospective study evaluated consecutive patients who underwent Tip-in EMR or ESD for 20- to 30-mm nonpedunculated colorectal neoplasms at a Japanese tertiary cancer center between January 2014 ... Seven hundred nine lesions were evaluated. The Tip-in EMR group included 1 lesion with a nonlifting sign but no lesions with fold convergence. After propensity score matching, each group included 140 ... Tip-in EMR is comparable with ESD with respect to the local recurrence rate but has a shorter procedure time, despite the lower en-bloc and R0 resection rates for 20- to 30-mm nonpedunculated colorect...

Clinical outcomes of endoscopic submucosal dissection for colorectal neoplasms: A single-center experience in Southern Taiwan.

Endoscopic submucosal dissection (ESD) as an advanced endoscopic procedure can be considered for the removal of colorectal lesions with high suspicion of limited submucosal invasion or cannot be optim... We retrospectively enrolled 230 patients with 244 colorectal neoplasms who received ESD procedures from April 2012 to October 2020 at Kaohsiung Chang Gung Memorial Hospital. Clinicopathological data w... The average age was 64 years old, with a mean follow-up time of 22.59 months. There was a loss of follow-up in 34 lesions. Most lesions were lateral spreading tumors of the non-granular type. The aver... ESD for colorectal neoplasms is an effective and safe technique. Size ≥ 10 cm2 and endoscopist's experience < 3 years were significantly associated with long procedure time. Pre-ESD EUS provided a goo...

Risk prediction of second primary malignancies in primary colorectal neuroendocrine neoplasms patients: a population-based study.

In this study, we aimed to identify risk factors for developing second primary malignancies (SPMs) in colorectal neuroendocrine neoplasms (NENs) patients and develop a competing-risk nomogram to predi... Patients with colorectal NENs were retrospectively collected from the Surveillance, Epidemiology, and End Results (SEER) database during 2000-2013. Potential risk factors for SPMs' occurrence in color... We identified 11,017 colorectal NENs' patients, and randomly divided them into training (n = 7711 patients) and validation (n = 3306 patients) cohorts. In the whole cohort, 12.4% patients (n = 1369) h... This research identified risk factors for SPMs' occurrence in colorectal NENs' patients. Competing-risk nomogram was constructed and proved to have good performance....

Treatment indicators and prognostic factors in colorectal neuroendocrine neoplasms and adenocarcinoma with neuroendocrine differentiation: a single center retrospective study.

This study compared survival and metastasis occurrence between colorectal neuroendocrine neoplasms (cNEN) and colorectal adenocarcinoma with neuroendocrine differentiation (cNED) and further explored ... Patients diagnosed as cNEN and cNED in West China Hospital from January 2009 to December 2020 were enrolled. The diagnosis and metastasis rates were calculated. Univariate and multivariate Cox analyse... The study enrolled 435 patients, including 257 neuroendocrine tumors (NET), 52 neuroendocrine carcinomas (NEC), 29 mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN), and 97 NED patients, of wh... cNEN show high metastatic capacity and are challenging to diagnose. More aggressive treatment and follow-up strategies are necessary for those patients. NET tumor grade higher than G2, size larger tha...

Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.

This study aims to determine whether Pokemon regulates Bim activity in colorectal carcinoma (CRC) carcinogenesis.... Clinical tissue samples were analyzed to detect the expression and clinicopathological significance of Pokemon and Bim in CRC. Proliferation, apoptosis, and invasion assays were conducted to identify ... Immunohistochemical analysis of 80 samples of colorectal epithelia (CRE), 80 cases of colorectal adenoma (CRA), and 160 of CRC samples revealed protein expression rates of 23.8%, 38.8%, and 70.6% for ... These findings suggest that Pokemon inhibits Bim transcription, thereby promoting CRC proliferation, resistance to apoptosis, invasion, and advancing histological grade and Dukes staging. Pokemon knoc...

Endoscopic submucosal tunnel dissection vs conventional endoscopic submucosal dissection for large colorectal neoplasms: a single-centre retrospective study.

Colorectal endoscopic submucosal dissection (ESD) is still not widely used due to its technical difficulty and the risk of complications. Several techniques, such as traction techniques, pocket techni... The charts of consecutive patients referred to the Arcispedale Santa Maria Nuova (Reggio Emilia, Italy) for colorectal ESD between January 2014 and February 2021 for colorectal neoplasms > 40 mm were ... There were 59 patients (M:F ratio 29:30, median age 70 years [range 50-93 years]). Of 59 colorectal lesions > 40 mm, 25 were removed by ESTD and 34 by CESD. The en bloc resection rate was 100% in both... ESTD achieves a very high en bloc resection rate and is faster than CESD....