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Protéines et peptides de signalisation intercellulaire
Protéine apparentée à l'hormone parathyroïdienne
Protéine apparentée à l'hormone parathyroïdienne : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"description": "Comment diagnostiquer une élévation de PTHrP ?\nQuels tests sont utilisés pour évaluer l'hypercalcémie ?\nQuels examens d'imagerie sont recommandés ?\nQuand suspecter un cancer lié à PTHrP ?\nQuels marqueurs tumoraux sont associés à PTHrP ?",
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"headline": "Facteurs de risque sur Protéine apparentée à l'hormone parathyroïdienne",
"description": "Quels sont les principaux facteurs de risque ?\nLe sexe influence-t-il le risque ?\nLes antécédents familiaux jouent-ils un rôle ?\nL'obésité est-elle un facteur de risque ?\nLes maladies auto-immunes sont-elles un facteur ?",
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"@type": "Question",
"name": "Comment diagnostiquer une élévation de PTHrP ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un dosage sanguin de PTHrP est effectué pour évaluer son niveau."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'hypercalcémie ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins pour le calcium et la PTHrP sont réalisés."
}
},
{
"@type": "Question",
"name": "Quels examens d'imagerie sont recommandés ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des échographies ou des IRM peuvent être utilisés pour détecter des tumeurs."
}
},
{
"@type": "Question",
"name": "Quand suspecter un cancer lié à PTHrP ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "En cas d'hypercalcémie inexpliquée, surtout chez les patients cancéreux."
}
},
{
"@type": "Question",
"name": "Quels marqueurs tumoraux sont associés à PTHrP ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le dosage de PTHrP peut être un marqueur dans certains cancers, comme le cancer du poumon."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une élévation de PTHrP ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, nausées, et douleurs osseuses."
}
},
{
"@type": "Question",
"name": "Comment l'hypercalcémie se manifeste-t-elle ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut provoquer des vomissements, des troubles de la conscience et des douleurs abdominales."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes cutanés associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des démangeaisons ou des éruptions cutanées peuvent survenir dans certains cas."
}
},
{
"@type": "Question",
"name": "Quels symptômes neurologiques peuvent apparaître ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Confusion, faiblesse musculaire et troubles de la coordination peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Les douleurs osseuses sont-elles fréquentes ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont courantes en raison de l'impact de l'hypercalcémie sur les os."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir l'élévation de PTHrP ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention spécifique, mais un suivi médical est essentiel."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque de cancer associé ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant une alimentation équilibrée et l'exercice, peut aider."
}
},
{
"@type": "Question",
"name": "Les dépistages réguliers sont-ils recommandés ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, surtout pour les personnes à risque élevé de cancers associés à PTHrP."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs de risque modifiables ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter le tabagisme et l'alcool peut réduire le risque de certains cancers."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'alimentation ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en calcium et en vitamine D peut soutenir la santé osseuse."
}
},
{
"@type": "Question",
"name": "Quel traitement est utilisé pour l'hypercalcémie ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'hydratation intraveineuse et les diurétiques peuvent être administrés."
}
},
{
"@type": "Question",
"name": "Les bisphosphonates sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils aident à réduire le taux de calcium en inhibant la résorption osseuse."
}
},
{
"@type": "Question",
"name": "Quand envisager une chirurgie ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Si une tumeur sécrétant PTHrP est identifiée, une intervention chirurgicale peut être nécessaire."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements ciblés pour PTHrP ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies ciblées peuvent être envisagées dans le cadre de certains cancers."
}
},
{
"@type": "Question",
"name": "Comment gérer les douleurs osseuses ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des analgésiques et des traitements anti-inflammatoires peuvent être prescrits."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec PTHrP ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des fractures osseuses et des troubles rénaux."
}
},
{
"@type": "Question",
"name": "L'hypercalcémie peut-elle entraîner des complications graves ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut provoquer des arythmies cardiaques et des défaillances rénales."
}
},
{
"@type": "Question",
"name": "Quels sont les risques à long terme ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des dommages osseux permanents et des problèmes rénaux peuvent survenir."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications liées aux traitements ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains traitements peuvent entraîner des effets secondaires comme des douleurs abdominales."
}
},
{
"@type": "Question",
"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des contrôles réguliers des niveaux de calcium et de la fonction rénale sont nécessaires."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents de cancer, l'âge avancé et des maladies endocriniennes augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le sexe influence-t-il le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains cancers liés à PTHrP sont plus fréquents chez les hommes."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un historique familial de cancer peut augmenter le risque de PTHrP."
}
},
{
"@type": "Question",
"name": "L'obésité est-elle un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'obésité est associée à un risque accru de plusieurs types de cancer."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles un facteur ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies auto-immunes peuvent augmenter le risque de cancers associés à PTHrP."
}
}
]
}
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Hepatocellular carcinoma (HCC) patients at advanced stages receive immunotherapy or treatment with tyrosine kinase inhibitors (TKIs) such as Sorafenib (Sora) or Lenvatinib in frontline as well as Rego...
In this study, we addressed the impact of the receptor tyrosine kinase Axl binding to its ligand Gas6 in acquiring refractoriness to TKIs. The initial responses of Axl-positive and Axl-negative cell l...
We show that HCC cells exhibiting a mesenchymal-like phenotype were less sensitive to drug treatment, linking TKI resistance to changes in epithelial plasticity. Gas6/Axl expression and activation wer...
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Here, miR-429 was overexpressed using lentiviral vectors in U-251 and U-87 GBM cells and it was observed that the expression level of several oncogenes of the ERBB pathway, EGFR, PIK3CA, PIK3CB, KRAS,...
Altogether, miR-429 seems to be an efficient suppressor of the ERBB genetic signaling pathway and a potential therapeutic for GBM....
The ERBBprofiler assay measures compound effects on ERBB family receptors and key downstream signaling pathways that are implicated in cancer or other complex diseases. Here, we present a protocol for...
Hepatocellular carcinoma (HCC) is a highly heterogeneous and aggressive tumor. In recent years, the incidence of HCC has been increasing worldwide. Despite notable advancements in treatment methodolog...
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Patients with actionable somatic mutations or amplifications in ERBB genes or actionable KRAS mutations were enrolled to receive neratinib and trametinib in this phase I dose escalation trial. The pri...
Twenty patients were enrolled with a median age of 50.5 years and a median of 3 lines of prior therapy. Grade 3 treatment-related toxicities included: diarrhea (25%), vomiting (10%), nausea (5%), fati...
Neratinib and trametinib combination was toxic and had limited clinical efficacy. This may be due to suboptimal drug dosing given drug-drug interactions....
NCT03065387....
ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders. Although existing drugs target ERBB receptors, the next g...
Gallbladder cancer (GBC) is an aggressive type of digestive system cancer with a dismal outcome. Given the lack of effective treatment options, the disease rapidly reoccurs and 5-year survival rate is...
We conduct a multicentre and randomised study on afatinib combined with gemcitabine and oxaliplatin (GEMOX) in patients with ErbB pathway mutated GBC. Clinical and biological evaluation involving ErbB...
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NCT04183712....
Epidermal growth factor receptor (EGFR), which is referred to as ErbB1/HER1, is the prototype of the EGFR family of receptor tyrosine kinases which also comprises ErbB2 (Neu, HER2), ErbB3 (HER3), and ...
Current therapies targeting the human epidermal growth factor receptor (HER) family, including monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs), are limited by drug resistance and sy...
Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with ...