Comment diagnostiquer une dysfonction des métalloprotéases ?

Des tests sanguins et des biopsies tissulaires peuvent évaluer l'activité des métalloprotéases.

Quels marqueurs sont utilisés pour le diagnostic ?

Les niveaux de métalloprotéases dans le sérum ou les tissus peuvent servir de marqueurs diagnostiques.

Les imageries sont-elles utiles pour le diagnostic ?

Oui, l'imagerie peut aider à visualiser les tissus affectés par des déséquilibres enzymatiques.

Quels tests génétiques sont disponibles ?

Des tests génétiques peuvent identifier des mutations affectant la production de métalloprotéases.

Comment évaluer l'activité enzymatique ?

Des tests enzymatiques spécifiques mesurent l'activité des métalloprotéases dans les échantillons.

Quels symptômes indiquent une surproduction de métalloprotéases ?

Une inflammation, des douleurs articulaires et des lésions tissulaires peuvent survenir.

Les symptômes varient-ils selon le type de métalloprotéases ?

Oui, différents types de métalloprotéases peuvent causer des symptômes variés selon les tissus affectés.

Quels signes cliniques sont associés à une déficience ?

Une cicatrisation lente et des anomalies dans la matrice extracellulaire peuvent être observées.

Les symptômes sont-ils toujours visibles ?

Non, certaines dysfonctions peuvent être asymptomatiques jusqu'à des stades avancés.

Comment les symptômes évoluent-ils avec l'âge ?

L'activité des métalloprotéases peut augmenter avec l'âge, aggravant les symptômes dégénératifs.

Comment prévenir les maladies liées aux métalloprotéases ?

Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, peut aider.

Les suppléments nutritionnels sont-ils utiles ?

Certains suppléments, comme les antioxydants, peuvent soutenir la fonction des métalloprotéases.

L'évitement de certains aliments est-il recommandé ?

Oui, réduire les aliments pro-inflammatoires peut aider à réguler l'activité des métalloprotéases.

Le contrôle du stress est-il important ?

Oui, le stress peut influencer l'activité des métalloprotéases, donc sa gestion est cruciale.

Les examens réguliers sont-ils nécessaires ?

Des examens réguliers peuvent aider à détecter précocement des déséquilibres enzymatiques.

Quels traitements ciblent les métalloprotéases ?

Des inhibiteurs spécifiques des métalloprotéases sont utilisés pour traiter certaines maladies.

Les thérapies géniques sont-elles une option ?

Oui, la thérapie génique peut corriger des mutations affectant la production de métalloprotéases.

Comment les anti-inflammatoires aident-ils ?

Ils peuvent réduire l'inflammation causée par une suractivité des métalloprotéases.

Les traitements sont-ils personnalisés ?

Oui, les traitements peuvent être adaptés en fonction du type de métalloprotéases impliqué.

Quels sont les effets secondaires des inhibiteurs ?

Les inhibiteurs peuvent causer des effets secondaires comme des troubles gastro-intestinaux.

Quelles complications peuvent survenir avec une suractivité ?

Des maladies dégénératives, comme l'arthrite, peuvent résulter d'une suractivité des métalloprotéases.

Les complications sont-elles réversibles ?

Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non.

Comment les complications affectent-elles la qualité de vie ?

Elles peuvent entraîner des douleurs chroniques et une mobilité réduite, affectant la qualité de vie.

Les complications sont-elles prévisibles ?

Certaines complications peuvent être prévisibles en surveillant les niveaux d'activité enzymatique.

Quelles sont les complications liées à une déficience ?

Une cicatrisation lente et des infections peuvent survenir en raison d'une déficience en métalloprotéases.

Quels facteurs augmentent le risque de dysfonction ?

L'âge, le mode de vie sédentaire et une alimentation déséquilibrée augmentent le risque.

Les antécédents familiaux jouent-ils un rôle ?

Oui, des antécédents familiaux de maladies liées aux métalloprotéases peuvent augmenter le risque.

Le tabagisme est-il un facteur de risque ?

Oui, le tabagisme peut exacerber l'activité des métalloprotéases et augmenter les maladies associées.

Le stress chronique influence-t-il le risque ?

Oui, le stress chronique peut perturber l'équilibre des métalloprotéases, augmentant le risque de maladies.

L'exposition à des toxines est-elle un facteur ?

Oui, l'exposition à certaines toxines environnementales peut affecter l'activité des métalloprotéases.

Metalloproteases - Informations médicales vérifiées

Reliability of point-of-care ultrasound for measuring quadriceps femoris muscle thickness.

Oct 2022

DOI: 10.23736/S1973-9087.22.07432-9 PMID: 36052891

Point-of-care ultrasound can be used to assess muscle thickness. However, its reliability has not been fully evaluated.... This study aimed to assess the intrarater and inter-rater reliability of point-of-care ultrasound for the estimation of quadriceps and rectus femoris thickness in patients from a rehabilitation settin... This is a cross-sectional study.... This study was conducted at the Department of Physical Medicine and Rehabilitation of a tertiary care hospital.... Twenty-nine inpatients consecutively selected after admission.... Four observers, two trained and two untrained, used point-of-care ultrasound to measure quadriceps femoris and rectus femoris thickness. Each observer performed two measurements followed by a second s... Both intrarater and inter-rater ICC were higher than 0.888 for both quadriceps and rectus femoris measurements. Reliability was highest when ICC were calculated based on the average of two measurement... These results suggest that point-of-care ultrasound is a reliable option to measure muscle thickness of knee extensors by the same or different observers.... Measuring knee extensors thickness may aid to adequately modulate treatment choices in patients with disability. This study suggests that quadriceps and rectus femoris muscle thickness measured after ...

Cross-Sectional Studies Humans Point-of-Care Systems Quadriceps Muscle Reproducibility of Results +1 autres

Motor point heatmap guide for neuromuscular electrical stimulation of the quadriceps muscle.

Jun 2023

DOI: 10.1016/j.jelekin.2023.102771 PMID: 37054655

To create an anatomical chart that indicates the probability of finding a motor point (MP) in different areas of the quadriceps muscle.... On 31 healthy adults, the individual anatomy of the vastus medialis (VM), rectus femoris (RF) and vastus lateralis (VL) was determined using ultrasound. Thereafter, a 3 Hz neuromuscular electrical sti... The heat-map displayed the two best 3x3cm areas, over VL and VM respectively, each with a probability greater than 50% of finding a MP and a higher probability compared to all other areas (p <.05). RF... Large inter-individual variations in location, and number of MPs were found, but the heat-map displayed areas with higher probability of finding a MP and can be used to facilitate NMES-application....

Adult Humans Quadriceps Muscle Muscle, Skeletal Lower Extremity +3 autres

Ultrasound quadriceps muscle thickness is variably associated with frailty in haemodialysis recipients.

18 01 2023

DOI: 10.1186/s12882-022-03043-8 PMID: 36653750

Ultrasonographic quantitation of quadriceps muscle mass is increasingly used for assessment of sarcopenia, but its relationship with frailty in haemodialysis recipients is not known. This study explor... This was an exploratory analysis of a subgroup of adult prevalent (≥3 months) haemodialysis recipients deeply phenotyped for frailty. Ultrasound assessment of BATT was obtained with participants at an... In total 223 study participants had ultrasound measurements. Frailty ranged from 34% for FP to 58% for FI. BATT was associated with increasing frailty on simple linear regression by all frailty tools,... Ultrasound measures of quadriceps thickness is variably associated with frailty in prevalent haemodialysis recipients, dependent upon the frailty tool used, but not independent of other variables. Fur... Clinicaltrials.gov : NCT03071107 registered 06/03/2017....

Aged Humans Frail Elderly Frailty Geriatric Assessment +3 autres

Relationship between quadriceps muscle computed tomography measurement and motor function, muscle mass, and sarcopenia diagnosis.

2023

DOI: 10.3389/fendo.2023.1259350 PMID: 38047116

The quadriceps muscle is one of the human body's largest and most clinically important muscles and is evaluated using mid-thigh computed tomography (CT); however, its relationship with motor function ... A total of 472 middle-aged and older community dwellers (254 men and 218 women) aged ≥40 years (mean age: 62.3 years) were included in this study. The quantity and quality of the quadriceps muscle wer... In men, CSA and CSA×CTV were significantly associated with seven of the eight motor functions (p<0.05), excluding only balance ability. BMI-corrected CSA was significantly correlated with all eight mo... The present results showed that a single CT image of the quadriceps muscle at the mid-thigh is useful for diagnosing sarcopenic changes, such as loss of muscle mass, muscle weakness, and muscle functi...

Middle Aged Male Humans Female Aged +5 autres

Immunohistochemical analysis of the quadriceps femoris muscle before and after total knee arthroplasty.

Jan 2023

DOI: 10.1016/j.knee.2022.10.010 PMID: 36403397

The number of total knee arthroplasties (TKA) has increased steadily with the aging of the population. This surgical procedure is recognized for its success in pain relief and restoration of knee func... Muscle biopsies (VM and VL muscles) were collected from patients previously submitted to TKA via the medial parapatellar route and undergoing TKA revision (main group, n = 9) and patients with osteoar... The normal mosaic pattern of the medial and lateral knee muscles was observed in the main and control groups, with no evidence of peripheral nerve damage. Notably, 88.9 % of the patients exhibited mil... The medial parapatellar incision for TKA surgical access does not generate definitive morphological changes in the VM and VL muscle fibers but may contribute to VL atrophy....

Humans Arthroplasty, Replacement, Knee Quadriceps Muscle Knee Joint Knee +1 autres

Association of Regional Muscle Thickness and Echo Intensity with Muscle Volume, Intramuscular Adipose Tissue, and Strength of the Quadriceps Femoris.

2023

DOI: 10.2147/CIA.S424504 PMID: 37724172

This study aimed to investigate the association of muscle thickness (MT) and echo intensity (EI) obtained at different regions along the muscle length with muscle volume (MV), intramuscular adipose ti... A total of 135 community-dwelling adults (64 men and 71 women) participated in the study. Ultrasound scanning of the rectus femoris (RF) and vastus intermedius (VI) was performed at three locations (f... The correlation between RF-MT and RF-MV weakened as scanning approached the distal thigh, and the difference between the coefficients for the scanning locations was significant for women. However, the... The results of this study suggest that ultrasound measurements at the distal thigh can predict MV, IntraMAT, and muscle strength of the QF to the same degree as those at the mid-thigh....

Male Female Humans Quadriceps Muscle Thigh +3 autres

Wearable Neuromuscular Electrical Stimulation on Quadriceps Muscle Can Increase Venous Flow.

Dec 2023

DOI: 10.1007/s10439-023-03349-0 PMID: 37598135

Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) may increase venous blood flow to reduce the risk of venous thromboembolism. This study assessed whether Q-NMES pants could increase p...

Humans Quadriceps Muscle Venous Thromboembolism Muscle Contraction Electric Stimulation Therapy +3 autres

Comparison of The Effect of High- and Low-Frequency Vibration Foam Rolling on The Quadriceps Muscle.

09 2022

DOI: 10.52082/jssm.2022.376 PMID: 36157391

Vibration foam rolling (VFR) intervention has recently gained attention in sports and rehabilitation settings since the superimposed vibration with foam rolling can affect several physiological system...

Humans Isometric Contraction Male Muscle Strength Quadriceps Muscle +2 autres

Sex differences in quadriceps and inspiratory muscle fatigability following high-intensity cycling.

Mar 2023

DOI: 10.1016/j.jsams.2023.02.006 PMID: 36863893

As females have been hypothesized to have more fatigue resistant inspiratory muscles, this study aimed to compare the development of inspiratory and leg muscle fatigue between males and females follow... Cross-sectional comparison.... 17 healthy young males (27 ± 6 years, V̇O... Time to exhaustion was similar between sexes (p = 0.270, 95% CI -2.4 - 0.7 min). MVC of the quadriceps was lower after cycling for males (83.9 ± 11.5% vs. 94.0 ± 12.0% of baseline for females, p = 0.0... Females incur similar peripheral fatigue in the quadriceps and inspiratory muscles compared with men following high-intensity cycling, despite smaller reduction in voluntary force. This small differen...

Humans Male Female Sex Characteristics Cross-Sectional Studies +5 autres

Evaluation of Changes in Quadriceps Femoris Muscle in Critically III Children Using Ultrasonography.

06 2023

DOI: 10.1007/s12098-022-04220-1 PMID: 35834126

To measure changes in muscle thickness and echogenicity, reflecting muscle bulk and quality, respectively, of quadriceps femoris (QF), in critically ill children.... This study was done on 58 children aged 1-18 y requiring mechanical ventilation, admitted in a pediatric intensive care unit (PICU) of a tertiary care hospital from January 2018 to June 2019. QF thick... The median muscle thickness of QF was 1.58 cm, and vastus intermedius and rectus femoris echogenicity was 35.5 and 25.88 units, respectively in the present cohort, with median age of 6 y. Only 36 of t... There was a significant change in rectus femoris echogenicity, but not in QF thickness. Echogenicity rather than muscle thickness may be a more sensitive marker for changes in muscle properties....

Humans Child Quadriceps Muscle Intensive Care Units, Pediatric Ultrasonography +2 autres

Metalloproteases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Metalloendopeptidases

Metalloexopeptidases

Collagenases

Enzymes de conversion de l'endothéline

Gelatinases

Insulinase

Lysostaphin

Matrix metalloproteinases

Procollagen peptidase

Bacillus thermoproteolyticus neutral proteinase

Carboxypeptidases A

Cystinyl aminopeptidase

Glutamate carboxypeptidase II

Glutamyl aminopeptidase

Leucyl Aminopeptidase

Lysine carboxypeptidase

Microbial collagenase

Matrix metalloproteinase 14

Matrix metalloproteinase 15

Matrix metalloproteinase 16

Auteurs principaux

Sources (10000 au total)