Titre : Proteasome endopeptidase complex

Proteasome endopeptidase complex : Questions médicales fréquentes

Termes MeSH sélectionnés :

Gene Expression Profiling
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biologiques sont associés au protéasome ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les niveaux de protéines ubiquitinées et de certains cytokines peuvent indiquer une dysfonction." } }, { "@type": "Question", "name": "Quels tests génétiques peuvent être utiles ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des tests pour des mutations dans les gènes codant pour les sous-unités du protéasome peuvent être réalisés." } }, { "@type": "Question", "name": "Le diagnostic nécessite-t-il une biopsie ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Une biopsie peut être nécessaire pour évaluer la fonction du protéasome dans certains cas." } }, { "@type": "Question", "name": "Quels symptômes peuvent alerter sur un problème de protéasome ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme la fatigue, la faiblesse musculaire ou des troubles immunitaires peuvent survenir." } }, { "@type": "Question", "name": "Quels symptômes indiquent une défaillance du protéasome ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, faiblesse musculaire, et troubles neurologiques peuvent être des signes." } }, { "@type": "Question", "name": "Les troubles immunitaires sont-ils liés au protéasome ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une défaillance du protéasome peut entraîner une réponse immunitaire altérée." } }, { "@type": "Question", "name": "Peut-on observer des symptômes cutanés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des éruptions cutanées ou des lésions peuvent survenir en raison d'une inflammation." } }, { "@type": "Question", "name": "Les troubles métaboliques sont-ils associés ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles métaboliques peuvent résulter d'une dégradation protéique inefficace." } }, { "@type": "Question", "name": "Y a-t-il des symptômes neurologiques spécifiques ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des troubles cognitifs et des neuropathies peuvent être observés en cas de dysfonction." } }, { "@type": "Question", "name": "Comment prévenir les dysfonctionnements du protéasome ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent soutenir la fonction cellulaire." } }, { "@type": "Question", "name": "Le stress a-t-il un impact sur le protéasome ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter la fonction du protéasome et la santé cellulaire." } }, { "@type": "Question", "name": "L'exercice physique est-il bénéfique ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la fonction immunitaire." } }, { "@type": "Question", "name": "Des examens réguliers sont-ils recommandés ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Des examens réguliers peuvent aider à détecter précocement des dysfonctionnements." } }, { "@type": "Question", "name": "Les habitudes de sommeil influencent-elles le protéasome ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Un sommeil de qualité est crucial pour la régulation des fonctions cellulaires." } }, { "@type": "Question", "name": "Quels traitements ciblent le protéasome ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les inhibiteurs du protéasome, comme le bortezomib, sont utilisés dans certains cancers." } }, { "@type": "Question", "name": "La thérapie génique est-elle une option ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "La thérapie génique visant à corriger les mutations du protéasome est en recherche." } }, { "@type": "Question", "name": "Des traitements symptomatiques existent-ils ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des traitements pour gérer les symptômes comme la fatigue et la douleur sont disponibles." } }, { "@type": "Question", "name": "Les suppléments nutritionnels sont-ils bénéfiques ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments peuvent aider à soutenir la fonction cellulaire et la santé globale." } }, { "@type": "Question", "name": "La physiothérapie peut-elle aider ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la physiothérapie peut améliorer la force musculaire et la fonction physique." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec une dysfonction du protéasome ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme des cancers, des maladies neurodégénératives et des troubles immunitaires peuvent se développer." } }, { "@type": "Question", "name": "Les infections sont-elles plus fréquentes ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une fonction immunitaire altérée peut augmenter le risque d'infections." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de maladies auto-immunes ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une dysfonction du protéasome peut contribuer au développement de maladies auto-immunes." } }, { "@type": "Question", "name": "Les troubles métaboliques peuvent-ils s'aggraver ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles métaboliques peuvent s'aggraver en raison d'une dégradation protéique inefficace." } }, { "@type": "Question", "name": "Des troubles cognitifs peuvent-ils survenir ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles cognitifs peuvent être une complication de la dysfonction du protéasome." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque de dysfonction du protéasome ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'âge avancé, des antécédents familiaux et certaines maladies chroniques augmentent le risque." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il le risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque." } }, { "@type": "Question", "name": "Les expositions environnementales sont-elles un facteur ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des toxines environnementales peut affecter la fonction du protéasome." } }, { "@type": "Question", "name": "Le stress chronique est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut contribuer à la dysfonction du protéasome et à des maladies associées." } }, { "@type": "Question", "name": "Les infections virales peuvent-elles jouer un rôle ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections virales peuvent altérer la fonction du protéasome et augmenter le risque." } } ] } ] }

Sources (10000 au total)

Gene expression profiling of pancreatic ductal adenocarcinomas in response to neoadjuvant chemotherapy.

Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all major cancers. Chemotherapy is the mainstay systemic therapy for PDAC, and chemoresistance is a major clinical problem leadi... Archived formalin-fixed paraffin-embedded tumor tissue samples from patients treated with neoadjuvant chemotherapy were obtained during surgical resection. Specimens were macrodissected and gene expre... Initially, unsupervised multivariate modeling was performed by principal component analysis, which demonstrated a distinct gene expression profile between good- and poor-chemotherapy responders. There... A distinct tumor biological profile between PDAC patients who either respond or not respond to chemotherapy was identified....

Genes deregulated in giant cell arteritis by Nanostring nCounter gene expression profiling in temporal artery biopsies.

To identify differentially expressed genes in temporal artery biopsies (TABs) from patients with giant cell arteritis (GCA) with different histological patterns of inflammation: transmural inflammatio... Expression of 770 immune-related genes was profiled with the NanoString nCounter PanCancer Immune Profiling Panel on formalin-fixed paraffin-embedded TABs from 42 GCA patients with TMI, 7 GCA patients... Unsupervised clustering of the samples revealed two distinct groups: normal TABs and TABs with ILA in one group, 41/42 TABs with TMI in the other one. TABs with TMI showed 31 downregulated and 256 upr... TABs with TMI had a distinct transcriptome compared with normal TABs and TABs with ILA. The few genes potentially deregulated in ILA were also deregulated in TMI. Gene profiling allowed to deepen the ...

Identification and Validation of Common Reference Genes for Normalization of Esophageal Squamous Cell Carcinoma Gene Expression Profiles.

Esophageal squamous cell carcinoma (ESCC) is one of the subtypes of esophageal cancer with Chinese characteristics, and its five-year survival rate is less than 20%. Early diagnosis is beneficial to i...

Identification and Validation of Autophagy-Related Genes in Primary Ovarian Insufficiency by Gene Expression Profile and Bioinformatic Analysis.

To investigate the relationship between primary ovarian insufficiency and autophagy, we detected and got the expression profile of human granulosa cell line SVOG, which was with or without LPS induced... Totally, 6 genes were selected as candidate hub genes which might correlate with the process of primary ovarian insufficiency. The expression of hub genes was then validated by quantitative real-time ... The results indicated that autophagy might play an essential role in the process and underlying molecular mechanism of primary ovarian insufficiency, which was revealed for the first time and may help...

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in

The JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases... This study sought to investigate differential gene expression of several cytokines and their associated... Results showed that the gene expression levelsof both Th1 (... Our finding revealed dysregulation of cytokines and related...

Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells.

Gonadotrophic pituitary adenoma is a major subtype of pituitary adenoma in the sellar region, but it is rarely involved in the hypersecretion of hormones into blood; thus, it is commonly regarded as "... The hPASCs from 14 human gonadotrophic pituitary adenoma clinical samples were cultured and verified via immunohistochemistry. Genetic profiling of hPASCs and the matched tumor cells was performed thr... The hPASCs were successfully isolated and cultured from gonadotrophic pituitary adenoma in vitro, which were identified as positive for generic stem cell markers (Sox2, Oct4, Nestin and CD133) via imm... Genetic profiling of hPASCs may explain the tumorigenesis and invasiveness of gonadotrophic pituitary adenoma. ANXA2 may serve as a potential therapeutic target for the treatment of gonadotrophic pitu...