Titre : Lactames macrocycliques

Lactames macrocycliques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Hand Hygiene

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment diagnostiquer une infection bactérienne ?

Le diagnostic repose sur des cultures bactériennes et des tests de sensibilité.
Infections bactériennes Cultures bactériennes
#2

Quels tests sont utilisés pour les lactames macrocycliques ?

Des tests de sensibilité aux antibiotiques sont effectués pour évaluer l'efficacité.
Antibiotiques Tests de sensibilité
#3

Quels symptômes indiquent une infection nécessitant des lactames ?

Fièvre, douleur, inflammation et signes d'infection localisée peuvent indiquer une infection.
Symptômes Infections
#4

Comment évaluer l'efficacité des lactames macrocycliques ?

L'efficacité est évaluée par l'amélioration clinique et la réduction des cultures positives.
Efficacité Cultures positives
#5

Quels examens d'imagerie sont utiles ?

Des radiographies ou IRM peuvent être utilisées pour évaluer des infections profondes.
Imagerie médicale Infections profondes

Symptômes 5

#1

Quels sont les symptômes d'une infection bactérienne ?

Fièvre, frissons, douleur, rougeur et gonflement au site d'infection sont fréquents.
Symptômes Infections bactériennes
#2

Les lactames provoquent-ils des effets secondaires ?

Oui, des effets secondaires comme des éruptions cutanées ou des troubles gastro-intestinaux peuvent survenir.
Effets secondaires Eruptions cutanées
#3

Comment reconnaître une réaction allergique ?

Des démangeaisons, un gonflement ou des difficultés respiratoires peuvent indiquer une allergie.
Réaction allergique Démangeaisons
#4

Quels signes d'infection nécessitent une attention médicale ?

Une fièvre élevée persistante ou des douleurs intenses doivent être évaluées par un médecin.
Fièvre Douleurs
#5

Les lactames macrocycliques affectent-ils le système digestif ?

Oui, ils peuvent causer des nausées, vomissements ou diarrhées chez certains patients.
Système digestif Nausées

Prévention 5

#1

Comment prévenir les infections bactériennes ?

Une bonne hygiène, des vaccinations et un usage prudent des antibiotiques aident à prévenir.
Prévention Hygiène
#2

Les lactames macrocycliques sont-ils utilisés en prophylaxie ?

Oui, ils peuvent être utilisés en prophylaxie pour prévenir des infections post-chirurgicales.
Prophylaxie Infections post-chirurgicales
#3

Quelles mesures d'hygiène sont recommandées ?

Se laver les mains régulièrement et éviter le contact avec des personnes malades sont essentiels.
Hygiène Contact
#4

Les vaccinations aident-elles contre les infections ?

Oui, certaines vaccinations peuvent réduire le risque d'infections bactériennes spécifiques.
Vaccinations Infections bactériennes
#5

Comment éviter la résistance aux antibiotiques ?

Utiliser les antibiotiques uniquement lorsque nécessaire et suivre les prescriptions médicales.
Résistance aux antibiotiques Prescriptions médicales

Traitements 5

#1

Comment les lactames macrocycliques sont-ils administrés ?

Ils peuvent être administrés par voie intraveineuse ou orale, selon l'infection.
Administration Voie intraveineuse
#2

Quel est le mécanisme d'action des lactames ?

Ils inhibent la synthèse de la paroi cellulaire bactérienne, entraînant la mort des bactéries.
Mécanisme d'action Paroi cellulaire
#3

Combien de temps dure un traitement typique ?

La durée du traitement varie, mais elle est généralement de 7 à 14 jours selon l'infection.
Durée du traitement Infections
#4

Quels antibiotiques sont des lactames macrocycliques ?

Des exemples incluent la méropénème et l'imipénème, utilisés pour des infections graves.
Antibiotiques Méropénème
#5

Comment gérer les effets secondaires des lactames ?

Il est important de signaler tout effet indésirable au médecin pour ajuster le traitement.
Effets secondaires Ajustement du traitement

Complications 5

#1

Quelles complications peuvent survenir avec les lactames ?

Des réactions allergiques graves ou des infections secondaires peuvent survenir.
Complications Réactions allergiques
#2

Comment gérer une surinfection ?

Une évaluation médicale est nécessaire pour ajuster le traitement et cibler la nouvelle infection.
Surinfection Évaluation médicale
#3

Les lactames peuvent-ils causer des troubles rénaux ?

Oui, certains lactames peuvent affecter la fonction rénale, nécessitant une surveillance.
Troubles rénaux Surveillance
#4

Quels sont les signes d'une réaction sévère ?

Des symptômes comme des difficultés respiratoires ou un gonflement du visage nécessitent une urgence.
Réaction sévère Urgence médicale
#5

Les lactames macrocycliques peuvent-ils interagir avec d'autres médicaments ?

Oui, ils peuvent interagir avec d'autres médicaments, il est donc important d'informer le médecin.
Interactions médicamenteuses Médecin

Facteurs de risque 5

#1

Quels facteurs augmentent le risque d'infection ?

L'immunodépression, le diabète et les interventions chirurgicales augmentent le risque.
Facteurs de risque Immunodépression
#2

Les antécédents d'allergies influencent-ils le traitement ?

Oui, des antécédents d'allergies aux antibiotiques peuvent limiter les options de traitement.
Antécédents médicaux Allergies
#3

Le mode de vie affecte-t-il le risque d'infection ?

Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque.
Mode de vie Alimentation
#4

Les personnes âgées sont-elles plus à risque ?

Oui, les personnes âgées ont un système immunitaire affaibli, les rendant plus vulnérables.
Personnes âgées Système immunitaire
#5

Les voyages augmentent-ils le risque d'infections ?

Oui, les voyages peuvent exposer à des agents pathogènes inconnus, augmentant le risque d'infection.
Voyages Agents pathogènes
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Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale


Validation scientifique effectuée le 15/04/2025

Contenu vérifié selon les dernières recommandations médicales

Auteurs principaux

Jonathan L Sessler

3 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, United States.
Publications dans "Lactames macrocycliques" :

Chunju Li

3 publications dans cette catégorie

Affiliations :
  • College of Sciences, Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai, 200444, People's Republic of China. cjli@shu.edu.cn.
  • Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, 300387, People's Republic of China. cjli@shu.edu.cn.
Publications dans "Lactames macrocycliques" :

Zhongzhen Yang

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.

Adrian C Whitwood

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.

William P Unsworth

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.

Asaad S Mohamed

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.

Nouria A Al-Awadi

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.

Wei Zhou

2 publications dans cette catégorie

Affiliations :
  • State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.
Publications dans "Lactames macrocycliques" :

Qing He

2 publications dans cette catégorie

Affiliations :
  • State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.
Publications dans "Lactames macrocycliques" :

Zhi-Yuan Zhang

2 publications dans cette catégorie

Affiliations :
  • Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, 300387, People's Republic of China.
Publications dans "Lactames macrocycliques" :

David Esteban-Gómez

2 publications dans cette catégorie

Affiliations :
  • Centro de Investigacións Cientı́ficas Avanzadas (CICA) and Departamento de Quı́mica, Universidade da Coruña, Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain.
Publications dans "Lactames macrocycliques" :

Carlos Platas-Iglesias

2 publications dans cette catégorie

Affiliations :
  • Centro de Investigacións Cientı́ficas Avanzadas (CICA) and Departamento de Quı́mica, Universidade da Coruña, Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain.
Publications dans "Lactames macrocycliques" :

Lan-Ying Wang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Yun-Fei Zhang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

De-You Yang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Shu-Jing Zhang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Dan-Dan Han

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Yan-Ping Luo

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Kleopas Y Palate

1 publication dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.
Publications dans "Lactames macrocycliques" :

Yern-Hyerk Shin

1 publication dans cette catégorie

Affiliations :
  • Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.

Sources (5541 au total)

Hand hygiene compliance in the intensive care unit: Hand hygiene and glove changes.

Hand disinfection (HD) is known to be the single most effective prevention measure to avoid nosocomial infections, but the compliance rate (CR) remains low. The aim of this study was to determine the ... This is a single-blinded direct observation of employees of an.ßintensive care unit. One specially educated observer recorded all hand hygiene indications over a period of 21 8-hour shifts as well as ... Over a period of 168.ßhours, 2,036 HDs should be performed during the care for 1 intensive care unit patient. In total, only 690 HDs occurred, resulting in a CR of 33.9%. With regard to the nurses, th... Our results show that HD opportunities occur in high frequency during the treatment of critically ill patients. The compliance with HD remains too low, even when a 100% CR seems to be unachievable. Im...

Hand hygiene for the prevention of infections in neonates.

Annually, infections contribute to approximately 25% of the 2.8 million neonatal deaths worldwide. Over 95% of sepsis-related neonatal deaths occur in low- and middle-income countries. Hand hygiene is... To determine the effectiveness of different hand hygiene agents for preventing neonatal infection in both community and health facility settings.... Searches were conducted without date or language limits in December 2022 in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and Cumulated Index to Nursing and Allied Heal... We used standard methodological procedures expected by Cochrane and the GRADE approach to assess the certainty of evidence. Primary outcomes were incidence of suspected infection (author-defined in st... Our review included six studies: two RCTs, one cluster-RCT, and three cross-over trials. Three studies involved 3281 neonates; the remaining three did not specify the actual number of neonates include... We found a paucity of data that would allow us to reach meaningful conclusions pertaining to the superiority of one form of antiseptic hand hygiene agent over another for the prevention of neonatal in...

Automated hand hygiene compliance system's audible alert reminder increases healthcare worker hand hygiene compliance.

To evaluate the effectiveness of an automated hand hygiene compliance system (AHHCS) audible alert and vibration for increasing hand hygiene compliance.... A nonrandomized, before-and-after, quasi-experimental study of an AHHCS was implemented in several inpatient units. Over a 51-day period, the system's real-time audible alert was turned on, off, and b... This study was conducted at a level 1 trauma center, a regional academic health system with 1,564 beds.... The AHHCS was implemented in 9 inpatient units: 3 adult medical-surgical step-down units, and 6 adult intensive care units. The AHHCS badges were assigned to patient care assistants, registered nurses... In the 9 inpatient units, selected healthcare staff were issued wearable badges that detected entry into and exit from a patient room. The audible alert was turned on for 16 days, turned off for 17 da... Utilization of the AHHCS real-time audible alert reminder resulted in sustained HH compliance ≥90%. When the alert and vibration were deactivated, HH compliance dropped to an average of 74% (range, 62... Utilization of an AHHCS with real-time reminder audible alerts may be an effective method to increase healthcare worker HH compliance to ≥90%. Users of AHHCSs should consider the use of real-time remi...

Tailored positioning and number of hand rub dispensers: the fundamentals for optimized hand hygiene compliance.

Availability of alcohol-based hand rub (ABHR) dispensers at positions adapted to the work flow of healthcare workers (HCWs) is decisive in order to carry out indication-based hand rubbing. Although re... In order to analyse the impact of the location and number of ABHR dispensers on hand hygiene performance, additional dispensers were systematically placed in patient rooms in a surgical 38-bed ward at... The addition of dispensers increased ABHR consumption across the entire ward. Before the intervention, mean consumption was 20.6 mL/patient-day, whereas mean consumption after the intervention was 25.... ABHR consumption can be increased significantly by optimizing the position and number of dispensers. The outstanding factors are visibility and integrability of dispenser use into the work flow; in pa...

Clinical evaluation of an electronic hand hygiene monitoring system.

We aimed to test the accuracy of an electronic hand hygiene monitoring system (EHHMS) during daily clinical activities in different wards and with varying health care professions.... The accuracy of an EHHMS (Sani Nudge) was assessed during real clinical conditions by comparing events registered by two observers in parallel with events registered by the EHHMS. The events were cate... A total of 103 events performed by 25 health care workers (9 doctors, 11 nurses, and 5 cleaning assistants) were included in the analyses. The EHHMS had a sensitivity of 100% and a PPV of 100% when me... The objective accuracy measures demonstrate that this EHHMS can capture hand hygiene behavior under clinical conditions in different settings with clinical health care workers but show less accuracy w...

Use of thermal imaging to measure the quality of hand hygiene.

Hand hygiene has long been promoted as the most effective way to prevent the transmission of infection. However, due to low compliance and low quality of hand hygiene reported in previous studies, con... In total, 32 participants were recruited to participate in this study. Participants were required to perform four types of hand rubbing to achieve different coverage of the alcohol-based formulation. ... This system found promising results in terms of accuracy (93.5%) and Dice coefficient (87.1%) when observations took place 10 s after hand rubbing. At 60 s after hand rubbing, accuracy and Dice coeffi... Thermal imaging has potential for accurate, constant and systematic monitoring of the quality of hand hygiene....

Investigation of individual nurses' relative hand hygiene performance using an anonymous automated electronic hand hygiene monitoring system and a nursing assignment schedule.

We investigated whether an anonymous automated electronic monitoring system (EMS) could be used to compare hand hygiene (HH) performance of individual nurses.... Prospective observational cohort study. HH performance in 10 acute-care patient rooms was estimated through an EMS that anonymously measured HH events, and room entries and exits. The association betw... Over 99 days, there were 38,596 HH events and 135,546 room entries and exits (global HH performance, 28%). For 10 of 54 (19%) nurses, the median HH percentile rank of the rooms to which they were assi... An association exists between a room's HH rate and its assigned nurse. This association could hold potential value for an individualized feedback strategy....

Impact of direct hand hygiene observations and feedback on hand hygiene compliance among nurses and doctors in medical and surgical wards: an eight-year observational study.

The improvement of hand hygiene compliance (HHC) is vital for preventing healthcare-associated infections (HAIs).... To determine whether observation and feedback influences HHC among nurses and doctors in surgical and medical wards, and whether these actions impact HAI incidence.... In this longitudinal observational study, HHC and the incidence of HAIs were observed in six medical and seven surgical wards in a tertiary hospital in Finland from May 2013 to December 2020. Data of ... HH monitoring included 24,614 observations among nurses and 6396 observations among doctors. In medical wards, HHC rates increased 10.8%, from 86.2% to 95.5%, and HAI incidence decreased from 15.9 to ... Direct observations and feedback of HH increased HHC significantly among nurses and doctors over an eight-year period. During the same period, the incidence of HAIs significantly decreased in both med...

Train-the-Trainers in hand hygiene facilitate the implementation of the WHO hand hygiene multimodal improvement strategy in Japan: evidence for the role of local trainers, adaptation, and sustainability.

"Train-the-Trainers in hand hygiene" (TTT) is a standardized training to train infection prevention and control (IPC) practitioners with the aim to promote hand hygiene in health care according to the... Three TTT courses were conducted annually from 2020 to 2022 in Japan. A team "TTT-Japan" composed of more than 20 IPC practitioners who completed their first TTT participation adapted the original TTT... 158 Japanese healthcare workers participated in three TTT courses, the majority of whom (131, 82.9%) were nurses. Twenty-seven local trainers were involved in 2nd and 3rd TTTs. The scores of pre- and ... TTTs were successfully adapted and implemented in Japan, leading to sustained hand hygiene promotion activities by local trainers over three years. Further research is warranted to assess the long-ter...