Titre : Lactames macrocycliques

Lactames macrocycliques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Laparotomy
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Lactames macrocycliques", "description": "Quels sont les symptômes d'une infection bactérienne ?\nLes lactames provoquent-ils des effets secondaires ?\nComment reconnaître une réaction allergique ?\nQuels signes d'infection nécessitent une attention médicale ?\nLes lactames macrocycliques affectent-ils le système digestif ?", "url": "https://questionsmedicales.fr/mesh/D047029?mesh_terms=Laparotomy&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Lactames macrocycliques", "description": "Comment prévenir les infections bactériennes ?\nLes lactames macrocycliques sont-ils utilisés en prophylaxie ?\nQuelles mesures d'hygiène sont recommandées ?\nLes vaccinations aident-elles contre les infections ?\nComment éviter la résistance aux antibiotiques ?", "url": "https://questionsmedicales.fr/mesh/D047029?mesh_terms=Laparotomy&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Lactames macrocycliques", "description": "Comment les lactames macrocycliques sont-ils administrés ?\nQuel est le mécanisme d'action des lactames ?\nCombien de temps dure un traitement typique ?\nQuels antibiotiques sont des lactames macrocycliques ?\nComment gérer les effets secondaires des lactames ?", "url": "https://questionsmedicales.fr/mesh/D047029?mesh_terms=Laparotomy&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Lactames macrocycliques", "description": "Quelles complications peuvent survenir avec les lactames ?\nComment gérer une surinfection ?\nLes lactames peuvent-ils causer des troubles rénaux ?\nQuels sont les signes d'une réaction sévère ?\nLes lactames macrocycliques peuvent-ils interagir avec d'autres médicaments ?", "url": "https://questionsmedicales.fr/mesh/D047029?mesh_terms=Laparotomy&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Lactames macrocycliques", "description": "Quels facteurs augmentent le risque d'infection ?\nLes antécédents d'allergies influencent-ils le traitement ?\nLe mode de vie affecte-t-il le risque d'infection ?\nLes personnes âgées sont-elles plus à risque ?\nLes voyages augmentent-ils le risque d'infections ?", "url": "https://questionsmedicales.fr/mesh/D047029?mesh_terms=Laparotomy&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une infection bactérienne ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur des cultures bactériennes et des tests de sensibilité." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour les lactames macrocycliques ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de sensibilité aux antibiotiques sont effectués pour évaluer l'efficacité." } }, { "@type": "Question", "name": "Quels symptômes indiquent une infection nécessitant des lactames ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Fièvre, douleur, inflammation et signes d'infection localisée peuvent indiquer une infection." } }, { "@type": "Question", "name": "Comment évaluer l'efficacité des lactames macrocycliques ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "L'efficacité est évaluée par l'amélioration clinique et la réduction des cultures positives." } }, { "@type": "Question", "name": "Quels examens d'imagerie sont utiles ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des radiographies ou IRM peuvent être utilisées pour évaluer des infections profondes." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une infection bactérienne ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fièvre, frissons, douleur, rougeur et gonflement au site d'infection sont fréquents." } }, { "@type": "Question", "name": "Les lactames provoquent-ils des effets secondaires ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des effets secondaires comme des éruptions cutanées ou des troubles gastro-intestinaux peuvent survenir." } }, { "@type": "Question", "name": "Comment reconnaître une réaction allergique ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des démangeaisons, un gonflement ou des difficultés respiratoires peuvent indiquer une allergie." } }, { "@type": "Question", "name": "Quels signes d'infection nécessitent une attention médicale ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Une fièvre élevée persistante ou des douleurs intenses doivent être évaluées par un médecin." } }, { "@type": "Question", "name": "Les lactames macrocycliques affectent-ils le système digestif ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent causer des nausées, vomissements ou diarrhées chez certains patients." } }, { "@type": "Question", "name": "Comment prévenir les infections bactériennes ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une bonne hygiène, des vaccinations et un usage prudent des antibiotiques aident à prévenir." } }, { "@type": "Question", "name": "Les lactames macrocycliques sont-ils utilisés en prophylaxie ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent être utilisés en prophylaxie pour prévenir des infections post-chirurgicales." } }, { "@type": "Question", "name": "Quelles mesures d'hygiène sont recommandées ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Se laver les mains régulièrement et éviter le contact avec des personnes malades sont essentiels." } }, { "@type": "Question", "name": "Les vaccinations aident-elles contre les infections ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines vaccinations peuvent réduire le risque d'infections bactériennes spécifiques." } }, { "@type": "Question", "name": "Comment éviter la résistance aux antibiotiques ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Utiliser les antibiotiques uniquement lorsque nécessaire et suivre les prescriptions médicales." } }, { "@type": "Question", "name": "Comment les lactames macrocycliques sont-ils administrés ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent être administrés par voie intraveineuse ou orale, selon l'infection." } }, { "@type": "Question", "name": "Quel est le mécanisme d'action des lactames ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Ils inhibent la synthèse de la paroi cellulaire bactérienne, entraînant la mort des bactéries." } }, { "@type": "Question", "name": "Combien de temps dure un traitement typique ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La durée du traitement varie, mais elle est généralement de 7 à 14 jours selon l'infection." } }, { "@type": "Question", "name": "Quels antibiotiques sont des lactames macrocycliques ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des exemples incluent la méropénème et l'imipénème, utilisés pour des infections graves." } }, { "@type": "Question", "name": "Comment gérer les effets secondaires des lactames ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Il est important de signaler tout effet indésirable au médecin pour ajuster le traitement." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec les lactames ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des réactions allergiques graves ou des infections secondaires peuvent survenir." } }, { "@type": "Question", "name": "Comment gérer une surinfection ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Une évaluation médicale est nécessaire pour ajuster le traitement et cibler la nouvelle infection." } }, { "@type": "Question", "name": "Les lactames peuvent-ils causer des troubles rénaux ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains lactames peuvent affecter la fonction rénale, nécessitant une surveillance." } }, { "@type": "Question", "name": "Quels sont les signes d'une réaction sévère ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme des difficultés respiratoires ou un gonflement du visage nécessitent une urgence." } }, { "@type": "Question", "name": "Les lactames macrocycliques peuvent-ils interagir avec d'autres médicaments ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent interagir avec d'autres médicaments, il est donc important d'informer le médecin." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque d'infection ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'immunodépression, le diabète et les interventions chirurgicales augmentent le risque." } }, { "@type": "Question", "name": "Les antécédents d'allergies influencent-ils le traitement ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents d'allergies aux antibiotiques peuvent limiter les options de traitement." } }, { "@type": "Question", "name": "Le mode de vie affecte-t-il le risque d'infection ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque." } }, { "@type": "Question", "name": "Les personnes âgées sont-elles plus à risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes âgées ont un système immunitaire affaibli, les rendant plus vulnérables." } }, { "@type": "Question", "name": "Les voyages augmentent-ils le risque d'infections ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les voyages peuvent exposer à des agents pathogènes inconnus, augmentant le risque d'infection." } } ] } ] }

Sources (501 au total)

Assessing the impact of frailty in elderly patients undergoing emergency laparotomies in Singapore.

The global rise in ageing populations poses challenges for healthcare systems. By 2030, Singapore anticipates a quarter of its population to be aged 65 or older. This study addresses the dearth of res... Conducted at 2 tertiary centres in Singapore from January to December 2019, a retrospective cohort study examined EL outcomes in patients aged 65 or older. Frailty assessment, using the Clinical Frail... Among 233 participants, 26% were frail, revealing a higher vulnerability in the geriatric population. Frail individuals exhibited elevated preoperative risk, prolonged ICU stays, and significantly hig... Frailty emerged as a pivotal factor influencing the postoperative trajectory of older adults undergoing EL in Singapore. The integration of frailty assessment, particularly when combined with establis...

Characteristics of Laparoscopic Surgery for Trauma Patients and Risks of Conversion to Open Laparotomy.

The discussion is ongoing about appropriate indications for laparoscopic surgery in trauma patients. As timing and risks of conversion to laparotomy remain unclear, we aimed to elucidate characteristi... A retrospective observational study was conducted, using Japanese Trauma Data Bank (2004-2018). We included adult trauma patients who underwent laparoscopic surgery as an initial surgical intervention... Among 444 patients eligible for the study, 31 required conversions to laparotomy. The number of laparoscopic surgeries gradually increased over the study period (0.5-4.5% of trauma laparotomy), withou... Trauma laparoscopy for hemoperitoneum and peritoneal penetration were associated with higher incidence of conversion to open laparotomy....

Outcomes of Abdominal Firearm Injury and Damage Control Laparotomy in the Pediatric Population.

Firearm injuries (GSW) in the pediatric population is a public health crisis. Little is known about the outcomes of damage control laparotomy (DCL) following abdominal GSW. This study aims to evaluate... The trauma registry from an urban Level 1 trauma was queried for pediatric (0-18 y) GSW was queried from September 2013 to June 2020. Demographics, clinical variables, outcomes, readmissions, and reci... Abdominal GSW were identified in 83 patients (17% of all GSW). The median age was 16 [15-17], 84% were male and 86% Black. Violent intent accounted for 90% of GSW. The injury severity score was 16 [9-... Abdominal firearm injuries have high morbidity and mortality in the pediatric population. Damage control operations for abdominal GSWs are a valuable surgical option with similar outcomes to primary a...

Quantifying the impact of reduced opioid use in patients after emergency laparotomy.

Emergency laparotomies have high rates of morbidity and mortality. The evaluation and management of pain are crucial, as poorly managed pain may contribute to postoperative complications and increase ... This was a retrospective, observational study of patients presenting for emergency laparotomy due to trauma from 2014 to 2018. The primary objective was to define clinical outcomes that may be signifi... A total of 102 (35%), 84 (29%), and 105 (36%) patients were stratified into the low, moderate, and high groups, respectively. Mean pain scores for postoperative days 0 to 3 (P = .034), time to first b... Clinical outcomes, such as pain scores, and opioid-related adverse effects, such as time to first bowel movement and nasogastric tube duration, may be linked with the amount of opioids used....

Sarcopenia and visceral fat in patients with incisional hernia after urgent laparotomy.

Various risk factors have been associated with the development of incisional hernia (IH). Some recent papers underlined that visceral fat could be a reliable indicator. Another risk factor which is of... Patients aged 18 years or older who underwent urgent median laparotomy and with continuous direct suturing of the laparotomy were included. They were categorized into two groups: those with a median I... From January 2018 to May 2021, 364 patients underwent urgent surgery in our Department, of whom 222 were aged >18 years old and underwent median laparotomy. Forty-four patients had diagnosis of median... Even when surgery is performed in urgent settings, it could be important to identify patients at risk, especially as CT scans are generally available for all patients with urgent abdominal disease....

Apixaban for extended postoperative thromboprophylaxis in gynecologic oncology patients undergoing laparotomy.

Venous thromboembolic events represent the second most frequent cause of mortality in cancer patients. Recent literature shows that direct oral anticoagulants (DOAC) are at least as effective and safe... The Gynecologic Oncology Division at a large tertiary center transitioned from enoxaparin 40 mg daily to apixaban 2.5 mg BID for 28 days after laparotomies for gynecologic malignancies in November 202... Patient characteristics were similar between groups. No difference was found between total venous thromboembolism rates (4% vs. 3%, p = 0.49). No difference was found in postoperative readmission (5% ... Apixaban for 28-day postoperative thromboprophylaxis was found to be an effective and safe alternative to enoxaparin after laparotomies in a real-world cohort of gynecologic oncology patients....

Psychosocial outcomes following emergency laparotomy (POLO) study: a study protocol for a multicentre mixed-methods prospective cohort study assessing the psycho-social outcomes following emergency laparotomy in adults.

Morbidity from an emergency laparotomy (EmLap) is difficult to define and poorly understood. Morbidity is a holistic concept, reliant upon an interplay of bio-psychosocial outcomes that evolve long af... This is a multicentre, mixed-methods prospective 12-month cohort study with two participant populations: patient participants and family caregivers (FCGs). A target of 160 adult patients who undergo E... This study has received ethical approval (Wales REC7;12/WA/0297) and will be undertaken in accordance with the principles of Good Clinical Practice. We intend to disseminate study results in peer-revi... Clinical Trials.gov NCT05281627....

Getting back 'home' after emergency laparotomy: how many never make it?

Emergency laparotomy (EL) is performed on about 15 500 patients in Australia each year. Aside from mortality there is significant concern about the possibility that previously independent patients dis... Data were collected on all adult patients who underwent EL across four Australian hospitals over 2 years. A total of 113 data points were collected including pre-hospital residence, discharge destinat... A total of 782 patients underwent EL, the mean age was 64 years. Pre-admission, 95.5% of patients were living in their own home. Inpatient mortality was 7.0% and at discharge 72.4% of patients returne... Patients who survive 90 and 365 days following EL nearly all return to their pre-hospital residence, with only a very small proportion of previously independent patients entering dependent care. This ...

An 8-year retrospective review of emergency laparotomy outcomes in a Queensland rural hospital.

Emergency laparotomy (EL) is a major operation performed in critically unwell patients. The National Emergency Laparotomy Audit (NELA), undertaken in the UK since 2013 has shown progressive improvemen... A review of medical records between January 2014 and December 2021 of patients who undergo an EL. Data collected include patient demographics, clinical information, compliance to KPIs and the primary ... This is a descriptive quantitative study. The inclusion and exclusion criteria were similar to those defined in NELA and ANZELA-QI.... The general surgeons at the rural hospital provide emergency surgery services for the North-West Queensland community.... To review local clinical outcomes of 30-day mortality, LOS, and adherence to perioperative KPIs.... Overall, 84 patients met inclusion criteria. The median age (IQR) was 61 (48.8-70.3) years. The 30-day mortality was 3.6% and mean LOS was 12.8 (±13.4) days which was secondary to the low-risk patient... Local outcomes appear to be comparable to national and international benchmarks and a similar rural setting. The audited cohort outperformed the national standard in adherence to perioperative KPIs....