Titre : Lactames macrocycliques

Lactames macrocycliques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Length of Stay

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment diagnostiquer une infection bactérienne ?

Le diagnostic repose sur des cultures bactériennes et des tests de sensibilité.
Infections bactériennes Cultures bactériennes
#2

Quels tests sont utilisés pour les lactames macrocycliques ?

Des tests de sensibilité aux antibiotiques sont effectués pour évaluer l'efficacité.
Antibiotiques Tests de sensibilité
#3

Quels symptômes indiquent une infection nécessitant des lactames ?

Fièvre, douleur, inflammation et signes d'infection localisée peuvent indiquer une infection.
Symptômes Infections
#4

Comment évaluer l'efficacité des lactames macrocycliques ?

L'efficacité est évaluée par l'amélioration clinique et la réduction des cultures positives.
Efficacité Cultures positives
#5

Quels examens d'imagerie sont utiles ?

Des radiographies ou IRM peuvent être utilisées pour évaluer des infections profondes.
Imagerie médicale Infections profondes

Symptômes 5

#1

Quels sont les symptômes d'une infection bactérienne ?

Fièvre, frissons, douleur, rougeur et gonflement au site d'infection sont fréquents.
Symptômes Infections bactériennes
#2

Les lactames provoquent-ils des effets secondaires ?

Oui, des effets secondaires comme des éruptions cutanées ou des troubles gastro-intestinaux peuvent survenir.
Effets secondaires Eruptions cutanées
#3

Comment reconnaître une réaction allergique ?

Des démangeaisons, un gonflement ou des difficultés respiratoires peuvent indiquer une allergie.
Réaction allergique Démangeaisons
#4

Quels signes d'infection nécessitent une attention médicale ?

Une fièvre élevée persistante ou des douleurs intenses doivent être évaluées par un médecin.
Fièvre Douleurs
#5

Les lactames macrocycliques affectent-ils le système digestif ?

Oui, ils peuvent causer des nausées, vomissements ou diarrhées chez certains patients.
Système digestif Nausées

Prévention 5

#1

Comment prévenir les infections bactériennes ?

Une bonne hygiène, des vaccinations et un usage prudent des antibiotiques aident à prévenir.
Prévention Hygiène
#2

Les lactames macrocycliques sont-ils utilisés en prophylaxie ?

Oui, ils peuvent être utilisés en prophylaxie pour prévenir des infections post-chirurgicales.
Prophylaxie Infections post-chirurgicales
#3

Quelles mesures d'hygiène sont recommandées ?

Se laver les mains régulièrement et éviter le contact avec des personnes malades sont essentiels.
Hygiène Contact
#4

Les vaccinations aident-elles contre les infections ?

Oui, certaines vaccinations peuvent réduire le risque d'infections bactériennes spécifiques.
Vaccinations Infections bactériennes
#5

Comment éviter la résistance aux antibiotiques ?

Utiliser les antibiotiques uniquement lorsque nécessaire et suivre les prescriptions médicales.
Résistance aux antibiotiques Prescriptions médicales

Traitements 5

#1

Comment les lactames macrocycliques sont-ils administrés ?

Ils peuvent être administrés par voie intraveineuse ou orale, selon l'infection.
Administration Voie intraveineuse
#2

Quel est le mécanisme d'action des lactames ?

Ils inhibent la synthèse de la paroi cellulaire bactérienne, entraînant la mort des bactéries.
Mécanisme d'action Paroi cellulaire
#3

Combien de temps dure un traitement typique ?

La durée du traitement varie, mais elle est généralement de 7 à 14 jours selon l'infection.
Durée du traitement Infections
#4

Quels antibiotiques sont des lactames macrocycliques ?

Des exemples incluent la méropénème et l'imipénème, utilisés pour des infections graves.
Antibiotiques Méropénème
#5

Comment gérer les effets secondaires des lactames ?

Il est important de signaler tout effet indésirable au médecin pour ajuster le traitement.
Effets secondaires Ajustement du traitement

Complications 5

#1

Quelles complications peuvent survenir avec les lactames ?

Des réactions allergiques graves ou des infections secondaires peuvent survenir.
Complications Réactions allergiques
#2

Comment gérer une surinfection ?

Une évaluation médicale est nécessaire pour ajuster le traitement et cibler la nouvelle infection.
Surinfection Évaluation médicale
#3

Les lactames peuvent-ils causer des troubles rénaux ?

Oui, certains lactames peuvent affecter la fonction rénale, nécessitant une surveillance.
Troubles rénaux Surveillance
#4

Quels sont les signes d'une réaction sévère ?

Des symptômes comme des difficultés respiratoires ou un gonflement du visage nécessitent une urgence.
Réaction sévère Urgence médicale
#5

Les lactames macrocycliques peuvent-ils interagir avec d'autres médicaments ?

Oui, ils peuvent interagir avec d'autres médicaments, il est donc important d'informer le médecin.
Interactions médicamenteuses Médecin

Facteurs de risque 5

#1

Quels facteurs augmentent le risque d'infection ?

L'immunodépression, le diabète et les interventions chirurgicales augmentent le risque.
Facteurs de risque Immunodépression
#2

Les antécédents d'allergies influencent-ils le traitement ?

Oui, des antécédents d'allergies aux antibiotiques peuvent limiter les options de traitement.
Antécédents médicaux Allergies
#3

Le mode de vie affecte-t-il le risque d'infection ?

Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque.
Mode de vie Alimentation
#4

Les personnes âgées sont-elles plus à risque ?

Oui, les personnes âgées ont un système immunitaire affaibli, les rendant plus vulnérables.
Personnes âgées Système immunitaire
#5

Les voyages augmentent-ils le risque d'infections ?

Oui, les voyages peuvent exposer à des agents pathogènes inconnus, augmentant le risque d'infection.
Voyages Agents pathogènes
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Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale


Validation scientifique effectuée le 15/04/2025

Contenu vérifié selon les dernières recommandations médicales

Auteurs principaux

Jonathan L Sessler

3 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, United States.
Publications dans "Lactames macrocycliques" :

Chunju Li

3 publications dans cette catégorie

Affiliations :
  • College of Sciences, Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai, 200444, People's Republic of China. cjli@shu.edu.cn.
  • Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, 300387, People's Republic of China. cjli@shu.edu.cn.
Publications dans "Lactames macrocycliques" :

Zhongzhen Yang

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.

Adrian C Whitwood

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.

William P Unsworth

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.

Asaad S Mohamed

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.

Nouria A Al-Awadi

2 publications dans cette catégorie

Affiliations :
  • Department of Chemistry, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.

Wei Zhou

2 publications dans cette catégorie

Affiliations :
  • State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.
Publications dans "Lactames macrocycliques" :

Qing He

2 publications dans cette catégorie

Affiliations :
  • State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.
Publications dans "Lactames macrocycliques" :

Zhi-Yuan Zhang

2 publications dans cette catégorie

Affiliations :
  • Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, 300387, People's Republic of China.
Publications dans "Lactames macrocycliques" :

David Esteban-Gómez

2 publications dans cette catégorie

Affiliations :
  • Centro de Investigacións Cientı́ficas Avanzadas (CICA) and Departamento de Quı́mica, Universidade da Coruña, Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain.
Publications dans "Lactames macrocycliques" :

Carlos Platas-Iglesias

2 publications dans cette catégorie

Affiliations :
  • Centro de Investigacións Cientı́ficas Avanzadas (CICA) and Departamento de Quı́mica, Universidade da Coruña, Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain.
Publications dans "Lactames macrocycliques" :

Lan-Ying Wang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Yun-Fei Zhang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

De-You Yang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Shu-Jing Zhang

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Dan-Dan Han

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Yan-Ping Luo

1 publication dans cette catégorie

Affiliations :
  • Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, College of Plant Protection, Hainan University, Haikou 570228, China.
Publications dans "Lactames macrocycliques" :

Kleopas Y Palate

1 publication dans cette catégorie

Affiliations :
  • Department of Chemistry, University of York, Heslington York YO10 5DD UK William.unsworth@york.ac.uk.
Publications dans "Lactames macrocycliques" :

Yern-Hyerk Shin

1 publication dans cette catégorie

Affiliations :
  • Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.

Sources (8642 au total)

Effect of Instrumented Spine Surgery on Length of Stay.

Total joint arthroplasty studies have identified that surgeries that take place later in the week have a longer length of stay compared with those earlier in the week. This has not been demonstrated i... All instrumented spine surgeries in 2019 at a single academic tertiary center were retrospectively reviewed. Patients were categorized for surgical day and discharge disposition to home or a rehabilit... Seven hundred six patients were included in the analysis. Excluding Saturday, there were no differences in length of stay based on the day of surgery. Age older than 75 years, female, American Society... Day of surgery does not affect length of stay in instrumented spine surgeries. Discharge to a rehabilitation facility, however, did increase the length of stay as did age older than 75 years, higher A...

Perioperative risk factors impact on intensive care unit length of stay (ICU length of stay) in oral squamous cell carcinoma.

The trend in postoperative care for free flap patients is to deescalate from routine ICU admission into a specialty recovery unit. This study aims to investigate the predictive parameters in a routine... All patients who underwent ablative surgery for OSCC with free flap reconstruction and were managed in the ICU were included in this study. The primary outcome was ICU-length of stay. Perioperative, o... The study included 136 homogeneous patients, with a mean ICU length of stay of 4.5 (± 4.43 day). Patients with pre-operative positive renal dysfunction (P = 0.004), peripheral vascular disease (P < 0.... Patients with perioperative severe renal dysfunction, peripheral vascular disease, postoperative complication or high NYHA class are prone to have a significantly longer ICU length of stay. Several fa...

Frailty, length of stay and cost in hip fracture patients.

A hip fracture causes high morbidity and mortality. Frailty is associated with adverse outcomes and increased costs. Frailty measured using the Hospital Frailty Risk Score (HFRS) is associated with hi... Hip fractures account for an increasing number of hospital admissions around the world and are associated with high rates of morbidity and mortality. Frailty is increasingly recognized to be associate... A retrospective analysis was performed on 1014 patients ≥ 60 years who presented with a hip fracture between January 2016 to June 2020. Each patient was classified into HFRS low, intermediate or high ... Median total hospitalization costs were significantly higher in the highest HFRS (SGD$22,432) patients as compared to intermediate (SGD$18,759) and low HFRS (SGD$15,671) patients. The difference betwe... Frailty is associated with a marked increase in total costs in hip fracture patients. HFRS proved useful in estimating LOS and outcomes for older patients with hip fractures....

Length of Stay in Patients Undergoing Tracheoplasty: A NSQIP Study.

Prolonged length of stay (LOS) has been associated with increased morbidity and resource utilization in various surgical procedures. We aim to determine factors associated with increased hospital stay... The 2012-2018 National Surgical Quality Improvement Program (NSQIP) database was queried for patients undergoing tracheoplasty. Patient LOS was the primary clinical outcome. A LOS >75th percentile was... A total of 252 patients were queried. The majority of patients were female (67.5%), white (82.4%), and over the age of 65 (77.0%). Patients had a median LOS of 7 days with the 75th percentile cutoff b... This study elucidates factors associated with prolonged LOS in patients undergoing tracheoplasty. Patients with COPD and chronic steroid use were significantly associated with prolonged LOS.... 4 Laryngoscope, 133:1938-1942, 2023....

Genetic Testing and Hospital Length of Stay in Neonates With Epilepsy.

We evaluated changes in genetic testing for neonatal-onset epilepsy and associated short-term outcomes over an 8-year period among a cohort of patients in the neonatal intensive care unit (NICU) at a ... Our primary outcome was a change in length of stay (LOS) after 2018. We also ascertained severity of illness with the Neonatal Sequential Organ Failure Assessment (nSOFA), type and result of genetic t... Fifty-three infants with genetic testing were included; 20 infants were tested after 2018. A total of 4160 infants in the NICU without genetic testing were used as reference. In the genetic testing gr... In this cohort, changes in genetic testing for neonatal-onset epilepsy were associated with shorter LOS that was not explained by changes in severity of illness, birth weight, or the average LOS in th...

[Laboratories as predictors of length of hospital stay in patients with pneumonia].

There are several factors that influence the length of hospital stay (LoHS) in patients with community-acquired pneumonia (CAP). There is currently no study in the literature that correlates laborator... To find the association of laboratory parameters with the LoHS in patients with community-acquired pneumonia.... An observational, prospective, longitudinal, and controlled study was conducted in the emergency room of a secondary level hospital.... The mean time of LoHS in patients with CAP was 6.6 ± 3.0 days. The parameters of laboratory of monocytes, basophils and segmented neutrophils presented a correlation (Spearman rho) of 0.363, 0.364 and... LoHS in patients with CAP is related to the counting of monocytes, basophils, and neutrophils at the time of the hospital admittance and it was increased in patients with SAH and patients with COPD....

Laparoscopy in high-risk emergency general surgery reduces intensive care stay, length of stay and mortality.

Emergency general surgery patients undergoing laparoscopic surgery are at reduced risk of mortality and may require reduced length of critical care stay. This study investigated the effect of laparosc... Data were retrieved for all patients entered into the NELA database between 2013 and 2018. Only high-risk surgical patients (P-POSSUM predicted mortality risk of ≥ 5%) were included. Patients undergoi... A total of 66,517 high-risk patients received emergency major abdominal surgery. A laparoscopic procedure was attempted in 6998 (10.5%); of these, the procedure was competed laparoscopically in 3492 (... The results of this study suggest that in patients at high risk of post-operative mortality, laparoscopic emergency bowel surgery leads to a reduced length of critical care stay, overall length of sta...

Factors associated with an extended length of stay in the pediatric burn patient.

The Center for Medicaid and Medicare Services predicts the length of stay for pediatric burn patients based on several variables. However, many patients exceed their anticipated length. This study loo... We conducted a retrospective chart review of 535 pediatric burn patients admitted to our academic hospital from January 2018 to December 2020. 405 patients met inclusion criteria. Data were collected ... Average patient age was 3.36 years. 72.3% were treated for scald burns. Average length of stay was 13.5 days. 20.5% (n = 83) of patients exceeded their predicted length of stay. In comparing patients ... Twenty percent of pediatric burn patients had a longer length of stay than predicted by the Center for Medicaid and Medicare Services. Many factors were strongly associated with a longer-than-predicte...

Qualitative Analysis of Length of Stay and Readmission after Carotid Endarterectomy.

Length of stay (LOS) and readmissions are common measures to evaluate quality of health care. The objective of this study was to evaluate factors related to hospital LOS and readmission within 90 days... Using a single institution database, patients who underwent CEA for carotid stenosis between 2014 and 2019 were identified. Asymptomatic carotid stenosis (no history of any stroke or transient ischemi... There were 125 patients identified who underwent CEA for 133 carotid stenosis, and 8 patients had bilateral CEA; of which 36.8% were asymptomatic carotid stenosis with the remaining being operated on ... More than half of patients undergoing CEA for carotid stenosis were discharged after postoperative day 1. Interventions on modifiable clinical risk factors, such as morning CEA scheduling and manageme...

Association of Prophylaxis and Length of Stay With Venous Thromboembolism in Abdominopelvic Surgery.

Extended venous thromboembolism prophylaxis (eVTEp) is recommended for select patients who have undergone major abdominopelvic surgery to prevent postdischarge venous thromboembolism (pdVTE). Criteria... A retrospective cohort study of patients undergoing abdominopelvic surgery from January 2016 to February 2020 was performed using data from the Michigan Surgical Quality Collaborative. pdVTE was the m... A total of 45,637 patients underwent abdominopelvic surgery. Of which, 3063 (6.71%) were prescribed eVTEp. Two hundred eighty-five (0.62%) had pdVTE. Of the 285, 59 (21%) patients received eVTEp, whil... pdVTE was associated with increasing LOS but not with other VTE risk factors after propensity score matching. Current guidelines for eVTEp do not include LOS. Our findings suggest that LOS >5 d should...