Titre : Protéines de liaison au TGF-bêta latent

Protéines de liaison au TGF-bêta latent : Questions médicales fréquentes

Termes MeSH sélectionnés :

Attention Deficit and Disruptive Behavior Disorders
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anomalies cutanées ?\nLes troubles respiratoires sont-ils liés au TGF-bêta ?\nY a-t-il des signes d'inflammation systémique ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=1000#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Protéines de liaison au TGF-bêta latent", "description": "Comment prévenir les troubles liés au TGF-bêta ?\nY a-t-il des mesures spécifiques à prendre ?\nLes vaccinations sont-elles importantes ?\nL'éducation des patients est-elle cruciale ?\nLe suivi médical régulier est-il recommandé ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=1000#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Protéines de liaison au TGF-bêta latent", "description": "Quels traitements sont disponibles pour les troubles liés au TGF-bêta ?\nLa thérapie génique est-elle une option ?\nLes corticostéroïdes sont-ils utilisés ?\nY a-t-il des traitements expérimentaux ?\nLes changements de mode de vie peuvent-ils aider ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=1000#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Protéines de liaison au TGF-bêta latent", "description": "Quelles complications peuvent survenir ?\nLes complications cardiovasculaires sont-elles possibles ?\nY a-t-il un risque accru de cancer ?\nLes troubles neurologiques peuvent-ils être liés ?\nComment gérer les complications ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=1000#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Protéines de liaison au TGF-bêta latent", "description": "Quels sont les principaux facteurs de risque ?\nLe vieillissement est-il un facteur de risque ?\nL'obésité influence-t-elle le risque ?\nLe stress a-t-il un impact ?\nLes infections peuvent-elles être un facteur ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=1000#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une anomalie des protéines de liaison au TGF-bêta ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur des tests sanguins et des analyses génétiques pour détecter des mutations." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer le TGF-bêta ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des dosages immunologiques et des tests ELISA sont couramment utilisés pour mesurer le TGF-bêta." } }, { "@type": "Question", "name": "Les biopsies sont-elles nécessaires pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des biopsies peuvent être effectuées pour évaluer les tissus affectés et la présence de TGF-bêta." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème avec le TGF-bêta ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme l'inflammation chronique ou des troubles de cicatrisation peuvent indiquer un problème." } }, { "@type": "Question", "name": "Y a-t-il des marqueurs spécifiques pour ces protéines ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des marqueurs comme le TGF-bêta actif peuvent être utilisés pour évaluer leur fonction." } }, { "@type": "Question", "name": "Quels symptômes sont associés à une dysfonction du TGF-bêta ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent des troubles immunitaires, des fibroses et des anomalies de cicatrisation." } }, { "@type": "Question", "name": "La douleur est-elle un symptôme courant ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des douleurs peuvent survenir en raison d'inflammation ou de fibrose tissulaire." } }, { "@type": "Question", "name": "Peut-on observer des anomalies cutanées ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies cutanées comme des cicatrices hypertrophiques peuvent se produire." } }, { "@type": "Question", "name": "Les troubles respiratoires sont-ils liés au TGF-bêta ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles respiratoires peuvent survenir en raison de fibrose pulmonaire associée." } }, { "@type": "Question", "name": "Y a-t-il des signes d'inflammation systémique ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des signes comme la fièvre et la fatigue peuvent indiquer une inflammation systémique." } }, { "@type": "Question", "name": "Comment prévenir les troubles liés au TGF-bêta ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention passe par un mode de vie sain et la gestion des maladies inflammatoires." } }, { "@type": "Question", "name": "Y a-t-il des mesures spécifiques à prendre ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Éviter le tabac et l'alcool peut réduire le risque de complications liées au TGF-bêta." } }, { "@type": "Question", "name": "Les vaccinations sont-elles importantes ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les vaccinations peuvent aider à prévenir les infections qui exacerbent les troubles." } }, { "@type": "Question", "name": "L'éducation des patients est-elle cruciale ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, informer les patients sur les symptômes et les facteurs de risque est essentiel." } }, { "@type": "Question", "name": "Le suivi médical régulier est-il recommandé ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi médical régulier permet de détecter précocement les anomalies." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les troubles liés au TGF-bêta ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des médicaments anti-inflammatoires et des thérapies ciblées." } }, { "@type": "Question", "name": "La thérapie génique est-elle une option ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la thérapie génique est explorée pour corriger des anomalies génétiques liées au TGF-bêta." } }, { "@type": "Question", "name": "Les corticostéroïdes sont-ils utilisés ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les corticostéroïdes peuvent être prescrits pour réduire l'inflammation associée." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements expérimentaux, comme les inhibiteurs de TGF-bêta, sont en cours d'évaluation." } }, { "@type": "Question", "name": "Les changements de mode de vie peuvent-ils aider ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des changements comme une alimentation saine et l'exercice peuvent améliorer les symptômes." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des fibroses, des troubles respiratoires et des maladies auto-immunes." } }, { "@type": "Question", "name": "Les complications cardiovasculaires sont-elles possibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des complications cardiovasculaires peuvent survenir en raison d'une inflammation chronique." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des études suggèrent un lien entre TGF-bêta et certains types de cancer." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils être liés ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles neurologiques peuvent être associés à des déséquilibres du TGF-bêta." } }, { "@type": "Question", "name": "Comment gérer les complications ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "La gestion des complications nécessite une approche multidisciplinaire et un suivi régulier." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents familiaux, des maladies auto-immunes et l'exposition à des toxines." } }, { "@type": "Question", "name": "Le vieillissement est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement peut augmenter le risque de dysfonction des protéines de liaison au TGF-bêta." } }, { "@type": "Question", "name": "L'obésité influence-t-elle le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'obésité est associée à une inflammation chronique, augmentant le risque de troubles." } }, { "@type": "Question", "name": "Le stress a-t-il un impact ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut exacerber les troubles liés au TGF-bêta." } }, { "@type": "Question", "name": "Les infections peuvent-elles être un facteur ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines infections peuvent déclencher des réponses inflammatoires affectant le TGF-bêta." } } ] } ] }

Sources (10000 au total)

The Self-Evaluation of Negative Symptoms in Differentiating Deficit Schizophrenia: The Comparison of Sensitivity and Specificity with Other Tools.

Psychometric properties of the Self-evaluation of Negative Symptoms (SNS) in subjects with the deficit subtype of schizophrenia (SCZ-D) have not been investigated so far. This study had the following ... Participants were 82 stable outpatients with schizophrenia, including 40 individuals with SCZ-D and 42 individuals with the non-deficit subtype (SCZ-ND).... Internal consistency was acceptable-to-good in both groups. Factor analysis revealed two dimensions (apathy and emotional). There were significant positive correlations of the SNS total score with the... The present findings indicate that the SNS has good psychometric properties in subjects with SCZ-D and those with SCZ-ND. Moreover, the SNS, the PANSS, and the SOFAS might be used as screening tools f...

Rate control deficits during pinch grip and ankle dorsiflexion in early-stage Parkinson's disease.

Much of our understanding of the deficits in force control in Parkinson's disease (PD) relies on findings in the upper extremity. Currently, there is a paucity of data pertaining to the effect of PD o... The purpose of this study was to concurrently evaluate upper- and lower-limb force control in early-stage PD and a group of age- and gender-matched healthy controls.... Twenty individuals with PD and twenty-one healthy older adults participated in this study. Participants performed two visually guided, submaximal (15% of maximum voluntary contractions) isometric forc... Compared with controls, PD demonstrated slower rates of force development and force relaxation during the foot task, and a slower rate of relaxation during the hand task. Force variability was similar... Together, these results provide quantitative evidence of an impaired capacity in PD to produce submaximal and rapid force across multiple effectors. Moreover, results suggest that force control defici...

Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID.

The coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. The persistent symptoms of anosmia or hyposmia were associated in previous studies with the development of memor... One hundred twenty-eight long-COVID participants were recruited. Reported symptomatology, subjective memory complaints, anxiety and depression symptomatology, and trait-anxiety were assessed. Subjecti... The subjective memory complaints and the anxiety and depression symptoms were similar among the groups, but the score in general cognitive function was lower in the participants with symptoms of acute... Olfactory dysfunction in the acute phase of the infection by COVID-19 is related to cognitive deficits in objective tests, and mood disturbances are associated with self-reported and objective memory....

Structural brain signatures of frailty, defined as accumulation of self-reported health deficits in older adults.

Frailty in older adults has been associated with reduced brain health. However, structural brain signatures of frailty remain understudied. Our aims were: (1) Explore associations between a frailty in... We designed a cross-sectional observational study from a population-based study (The Irish Longitudinal Study on Aging: TILDA). Participants aged ≥50 years who underwent the wave 3 MRI sub-study were ... In 523 participants (mean age 69, 49% men), lower cortex and thalamic volumes were independently associated with higher FI. Sensory and functional difficulties, diabetes, polypharmacy, knee pain, and ... The FI used had a recognizable but subtle structural brain signature in this sample. Only some FI deficits were directly associated with cortex volume, suggesting scope for developing FIs that include...

P50 sensory gating, cognitive deficits and depressive symptoms in first-episode antipsychotics-naïve schizophrenia.

Sensory gating P50 (SG-P50) may be involved in the pathophysiological mechanisms of impaired cognition in schizophrenia (SCZ). Comorbid depressive symptoms are common in SCZ patients and are also foun... We recruited 103 FEAN-SCZ patients (depression: n = 63; non-depression: n = 40) and 55 healthy controls. SG-P50 was measured using the standard auditory dual-click (S1&S2) paradigm. Clinical symptoms ... Compared with non-depressive patients, depressive patients had a significantly larger S2 amplitude (p = 0.005) and a higher S2/S1 ratio at trend level (p = 0.075) after corrected. There were significa... SG-P50 deficit may be an informational biomarker for depressive symptoms and neurocognitive impairments in FEAN-SCZ patients....

Association of cholesterol level with dopamine loss and motor deficits in Parkinson disease: A cross-sectional study.

Cholesterol is vital in neuronal function; however, the influence of cholesterol levels on parkinsonism is unclear. This study investigated the relationship between baseline total cholesterol (TC) lev... This cross-sectional study enrolled 447 drug-naïve patients with PD who underwent dopamine transporter (DAT) imaging. Multivariate linear regression was used to investigate the effect of cholesterol l... No significant correlation was found between TC levels and DAT availability after adjusting for potential confounders. Multivariate linear regression showed that TC levels were significantly and negat... This study suggests that TC levels affect parkinsonian motor symptoms, especially in subjects with low cholesterol status, whereas the severity of axial motor symptoms is negatively associated with TC...

Assessment of Bioenergetic Deficits in Patients With Parkinson Disease and Progressive Supranuclear Palsy Using 31P-MRSI.

Bioenergetic disturbance, mainly caused by mitochondrial dysfunction, is an established pathophysiological phenomenon in neurodegenerative movement disorders. The... In total, 30 PwPD, 16 PwPSP, and 25 healthy control subjects (HCs) underwent a clinical examination, structural magnetic resonance imaging, and... High-energy phosphate metabolites were remarkably decreased in PwPD, particularly in the basal ganglia (-42% compared with healthy controls and -43% compared with PwPSP, p<.0001). This result was not ... Our study shows that mitochondrial dysfunction and bioenergetic depletion contribute to idiopathic Parkinson's disease pathophysiology but not to progressive supranuclear palsy. Combined morphometric ...