Titre : Protéines de liaison au TGF-bêta latent

Protéines de liaison au TGF-bêta latent : Questions médicales fréquentes

Termes MeSH sélectionnés :

Interrupted Time Series Analysis
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troubles respiratoires sont-ils liés au TGF-bêta ?\nY a-t-il des signes d'inflammation systémique ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Interrupted+Time+Series+Analysis&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Protéines de liaison au TGF-bêta latent", "description": "Comment prévenir les troubles liés au TGF-bêta ?\nY a-t-il des mesures spécifiques à prendre ?\nLes vaccinations sont-elles importantes ?\nL'éducation des patients est-elle cruciale ?\nLe suivi médical régulier est-il recommandé ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Interrupted+Time+Series+Analysis&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Protéines de liaison au TGF-bêta latent", "description": "Quels traitements sont disponibles pour les troubles liés au TGF-bêta ?\nLa thérapie génique est-elle une option ?\nLes corticostéroïdes sont-ils utilisés ?\nY a-t-il des traitements expérimentaux ?\nLes changements de mode de vie peuvent-ils aider ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Interrupted+Time+Series+Analysis&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Protéines de liaison au TGF-bêta latent", "description": "Quelles complications peuvent survenir ?\nLes complications cardiovasculaires sont-elles possibles ?\nY a-t-il un risque accru de cancer ?\nLes troubles neurologiques peuvent-ils être liés ?\nComment gérer les complications ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Interrupted+Time+Series+Analysis&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Protéines de liaison au TGF-bêta latent", "description": "Quels sont les principaux facteurs de risque ?\nLe vieillissement est-il un facteur de risque ?\nL'obésité influence-t-elle le risque ?\nLe stress a-t-il un impact ?\nLes infections peuvent-elles être un facteur ?", "url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Interrupted+Time+Series+Analysis&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une anomalie des protéines de liaison au TGF-bêta ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur des tests sanguins et des analyses génétiques pour détecter des mutations." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer le TGF-bêta ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des dosages immunologiques et des tests ELISA sont couramment utilisés pour mesurer le TGF-bêta." } }, { "@type": "Question", "name": "Les biopsies sont-elles nécessaires pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des biopsies peuvent être effectuées pour évaluer les tissus affectés et la présence de TGF-bêta." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème avec le TGF-bêta ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme l'inflammation chronique ou des troubles de cicatrisation peuvent indiquer un problème." } }, { "@type": "Question", "name": "Y a-t-il des marqueurs spécifiques pour ces protéines ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des marqueurs comme le TGF-bêta actif peuvent être utilisés pour évaluer leur fonction." } }, { "@type": "Question", "name": "Quels symptômes sont associés à une dysfonction du TGF-bêta ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent des troubles immunitaires, des fibroses et des anomalies de cicatrisation." } }, { "@type": "Question", "name": "La douleur est-elle un symptôme courant ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des douleurs peuvent survenir en raison d'inflammation ou de fibrose tissulaire." } }, { "@type": "Question", "name": "Peut-on observer des anomalies cutanées ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies cutanées comme des cicatrices hypertrophiques peuvent se produire." } }, { "@type": "Question", "name": "Les troubles respiratoires sont-ils liés au TGF-bêta ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles respiratoires peuvent survenir en raison de fibrose pulmonaire associée." } }, { "@type": "Question", "name": "Y a-t-il des signes d'inflammation systémique ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des signes comme la fièvre et la fatigue peuvent indiquer une inflammation systémique." } }, { "@type": "Question", "name": "Comment prévenir les troubles liés au TGF-bêta ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention passe par un mode de vie sain et la gestion des maladies inflammatoires." } }, { "@type": "Question", "name": "Y a-t-il des mesures spécifiques à prendre ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Éviter le tabac et l'alcool peut réduire le risque de complications liées au TGF-bêta." } }, { "@type": "Question", "name": "Les vaccinations sont-elles importantes ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les vaccinations peuvent aider à prévenir les infections qui exacerbent les troubles." } }, { "@type": "Question", "name": "L'éducation des patients est-elle cruciale ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, informer les patients sur les symptômes et les facteurs de risque est essentiel." } }, { "@type": "Question", "name": "Le suivi médical régulier est-il recommandé ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi médical régulier permet de détecter précocement les anomalies." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les troubles liés au TGF-bêta ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des médicaments anti-inflammatoires et des thérapies ciblées." } }, { "@type": "Question", "name": "La thérapie génique est-elle une option ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la thérapie génique est explorée pour corriger des anomalies génétiques liées au TGF-bêta." } }, { "@type": "Question", "name": "Les corticostéroïdes sont-ils utilisés ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les corticostéroïdes peuvent être prescrits pour réduire l'inflammation associée." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements expérimentaux, comme les inhibiteurs de TGF-bêta, sont en cours d'évaluation." } }, { "@type": "Question", "name": "Les changements de mode de vie peuvent-ils aider ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des changements comme une alimentation saine et l'exercice peuvent améliorer les symptômes." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des fibroses, des troubles respiratoires et des maladies auto-immunes." } }, { "@type": "Question", "name": "Les complications cardiovasculaires sont-elles possibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des complications cardiovasculaires peuvent survenir en raison d'une inflammation chronique." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des études suggèrent un lien entre TGF-bêta et certains types de cancer." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils être liés ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles neurologiques peuvent être associés à des déséquilibres du TGF-bêta." } }, { "@type": "Question", "name": "Comment gérer les complications ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "La gestion des complications nécessite une approche multidisciplinaire et un suivi régulier." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents familiaux, des maladies auto-immunes et l'exposition à des toxines." } }, { "@type": "Question", "name": "Le vieillissement est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement peut augmenter le risque de dysfonction des protéines de liaison au TGF-bêta." } }, { "@type": "Question", "name": "L'obésité influence-t-elle le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'obésité est associée à une inflammation chronique, augmentant le risque de troubles." } }, { "@type": "Question", "name": "Le stress a-t-il un impact ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut exacerber les troubles liés au TGF-bêta." } }, { "@type": "Question", "name": "Les infections peuvent-elles être un facteur ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines infections peuvent déclencher des réponses inflammatoires affectant le TGF-bêta." } } ] } ] }

Sources (10000 au total)

Impact of COVID-19 pandemic on food availability and affordability: an interrupted time series analysis in Ghana.

In Africa, approx. 675 million people were at risk of food insecurity. COVID-19 pandemic is likely to have exacerbated this situation, by damaging populations' access to and affordability of foods. Th... Data on food availability and food retail prices collected through weekly market-level data during the period from July 2017 to September 2020 were used in this study. We performed interrupted time-se... As a result, the impact of COVID-19 on food availability was limited. However, the results of interrupted time-series analyses indicate a significant increase in overall mean food prices in Greater Ac... The impact of COVID-19 pandemic on food availability and prices was significant but varied by food type and regions in Ghana. Continuous monitoring and responses are critical to maintain food availabi...

The effect of clinical guidelines on the utilisation of radiographs in chiropractic clinics in Denmark - an interrupted time series analysis.

In Denmark, chiropractors have a statutory right to use radiography and the government-funded national Health Insurance provides partial reimbursement. Danish National Clinical Guidelines recommends a... Anonymised data from January 1st, 2010, to December 31st, 2020, were extracted from the Danish Regions register on health contacts in primary care. Data consisted of the total number of patients consu... In total, 336,128 unique patients consulted a chiropractor in 2010 of which 55,449 (15.4%) had radiography. In 2020, the number of patients consulting a chiropractor had increased to 366,732 of which ... The proportion of Danish chiropractic patients undergoing radiography was halved in the period from 2010 to 2020. However, the dissemination of clinical imaging guidelines recommendations and policy c...

Impact of COVID-19 pandemic on Tuberculosis and HIV services in Ghana: An interrupted time series analysis.

The Coronavirus disease 2019 (COVID-19) burden, coupled with unprecedented control measures including physical distancing, travel bans, and lockdowns of cities, implemented to stop the spread of the v... The study involved the analysis of secondary data obtained from the District Health Information Management System-2 (DHIMS-2) database of Ghana Health Service, from 2016 to 2020. Data were analysed us... The study showed that during the COVID-19 pandemic period, there was an abrupt decline of 20.5% (955CI: 16.0%, 24.5%) in TB case notifications in April and 32.7% (95%CI: 28.8%, 39.1%) in May 2020, wit... This study demonstrated that the COVID-19 pandemic negatively impacted TB case notifications and HIV testing and counselling services, However, ART initiation was generally not impacted during the fir...

Using Preanesthesia Clinic Visits to Improve Advance Directives Completion: An Interrupted Time Series Analysis.

Advance directives documentation can increase the likelihood that patient's wishes are respected if they become incapacitated. Unfortunately, completion rates are suboptimal overall, and disparities m... We conducted a before-after interrupted time series evaluation between January 1, 2015 and June 30, 2019 in a single-center, outpatient preanesthesia clinic. Participants were adults who visited the p... We included 26,368 visits from 22,430 patients. We analyzed financial status for 16,788 visits from 14,274 patients who had address data. There were 11,242 (43%) visits preintervention and 15,126 (57%... Standardizing advance directives discussions during preanesthesia visits was associated with more patients completing advance directives, particularly in vulnerable patient groups....

Interrupted time series segmented regression analysis for detecting waterborne disease outbreaks by syndromic surveillance.

Pathogens can enter the drinking water supply and cause gastroenteritis outbreaks. Such events can affect many people in a short time, making them a high risk for public health. In Australia, the Vict... The study involved an interrupted time series study of a past lapse in water treatment. The baseline period comprised the four weeks before the minimum incubation period of suspected pathogens, set at... In the retrospective analysis, there was strong evidence for an increase in presentations shortly after the event. In the simulations, with no excess presentations (i.e., with the ED data as is) the m... The transient increase in presentations after the event may be attributed to microbiological hazards or increased health-seeking behaviour following the issuing of boil water advisories. The simulatio...

Impact of alcohol taxes on violence in Hong Kong: a population-based interrupted time series analysis.

Interpersonal violence is a major public health concern with alcohol use a known risk factor. Despite alcohol taxation being an effective policy to reduce consumption; Hong Kong, contrary to most deve... To assess the impact of the alcohol tax reductions, we analysed population-based hospitalisation data for assault from the Hong Kong Hospital Authority, and violent and sexual crimes recorded by the H... The 2007 tax cut was associated with sustained increases in violence-related hospitalisation rates for 35-49 age group (female: 0.19%, p=0.007; male: 0.22%, p<0.001; overall: 0.16%, p=0.007); and an i... Both alcohol tax reductions in 2007 and 2008 were in some age groups associated with increases in violence-related hospitalisations and reports of sexual assault even in an environment of low crime....

Impact of COVID-19 pandemic on road traffic injuries in Iran: An interrupted time-series analysis.

Globally, the COVID-19 pandemic has affected the number of road accidents and deaths caused by them. The present study aimed to identify the effect of this epidemic on traffic accidents and their casu... In this study, Interrupted Time Series Analysis (ITSA) was used in a semi-experimental design to measure the impact of the restrictive policies of COVID-19 on road accidents. Data were collected retro... Since February 2020 in Iran, the reduction in the number of road accidents and the number of injuries and deaths in these accidents was significant at 5% but the reduction of deaths in the scene and h... In the early months of the COVID-19 epidemic in Iran, the number of road accidents and their casualties decreased. Policies restricting traffic, quarantine, and fines for violators can be reasons for ...

Pediatric Injury Transfer Patterns During the COVID-19 Pandemic: An Interrupted time Series Analysis.

With the expected surge of adult patients with COVID-19, the Children's Hospital Association recommended a tiered approach to divert children to pediatric centers. Our objective was understanding chan... Children aged < 18 y injured between January 1, 2016 and September 30, 2020, who met National Trauma Databank inclusion criteria from 9 PTCs were included. An interrupted time-series analysis was used... Twenty seven thousand thirty one/47,382 injured patients (57.05%) were transferred to a participating PTC during the study period. Of the COVID cohort, 65.4% (4620/7067) were transferred, compared to ... Transferred trauma patients to Level I PTC increased during the COVID-19 pandemic. The proportion of transferred patients discharged from emergency departments increased. Pediatric trauma transfers ma...

The impact of policy interventions to promote the uptake of biosimilar medicines in Belgium: a nationwide interrupted time series analysis.

The Belgian government has taken several measures to increase the uptake of biosimilars in past years. However, no formal evaluation of the impact of these measures has been made yet. This study aimed... An interrupted time series analysis was performed using an autoregressive integrated moving average (ARIMA) model with the Box-Jenkins method. All data were expressed as defined daily doses (DDD) per ... In the ambulatory care, the effect of a financial prescriber incentive of 2019 was investigated. After this intervention, 44.504 (95% CI -61.61 to -14.812; P < 0.001) fewer etanercept biosimilar DDDs ... The results of this study suggest that the impact of past policy interventions to increase the uptake of biosimilars has been variable and limited. A holistic policy framework is required to develop a...

Prophylactic Enoxaparin Against Catheter-Associated Thrombosis in Postoperative Cardiac Children: An Interrupted Time Series Analysis.

The effectiveness of pharmacologic prophylaxis against catheter-associated thrombosis in children is unclear. We evaluated the compliance and outcomes associated with a prophylactic enoxaparin protoco... The protocol was implemented as a quality improvement initiative and then analyzed using interrupted time series method. Data collected from November 2014 to December 2018 were divided into preprotoco... A 12-bed academic pediatric cardiac ICU.... Children less than or equal to 18 years old with congenital heart disease admitted postoperatively with central venous catheter in situ for greater than or equal to 1 day.... Before 2016, prophylactic enoxaparin was administered according to physician preference. In January 2016, an enoxaparin protocol was implemented with a goal anti-Xa range of 0.25-0.49 international un... We analyzed 780 hospitalizations from 636 children. Median percentage of catheter-days on prophylactic enoxaparin was 33% (interquartile range [IQR], 23-47%), 42% (IQR, 30-51%), and 38% (IQR, 35-52%) ... The temporal association between increase in percentage of catheter-days on enoxaparin and decrease in rate of thrombosis suggests the effectiveness of prophylactic enoxaparin....