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Phénomènes chimiques
Phénomènes biochimiques
Conformation moléculaire
Conformation des protéines
Éléments structuraux des protéines
Motifs et domaines d'intéraction protéique
Motifs et domaines d'intéraction protéique : Questions médicales fréquentes
Termes MeSH sélectionnés :
Multicenter Studies as Topic
Diagnostic
5
Protéines
Bioinformatique
Immunoprécipitation
Interactions protéiques
Bioinformatique
Modélisation moléculaire
Conformation protéique
Complexes protéiques
Mutations
Interactions protéiques
Symptômes
5
Dysfonction protéique
Maladies auto-immunes
Cancer
Maladie d'Alzheimer
Maladies génétiques
Fonctions cellulaires
Inflammation
Troubles neurologiques
Prévention
5
Prévention
Mode de vie sain
Dépistage
Maladies génétiques
Vaccins
Réponse immunitaire
Traitements
5
Médicaments
Anticorps monoclonaux
Thérapie génique
Mutations
Inhibiteurs de protéines
Options thérapeutiques
Traitements ciblés
Fonction cellulaire
Thérapies combinées
Efficacité du traitement
Complications
5
Cancers
Maladies neurodégénératives
Maladies auto-immunes
Réponses immunes
Troubles métaboliques
Déséquilibres
Facteurs de risque
5
Facteurs de risque
Génétique
Vieillissement
Stabilité protéique
Infections virales
Perturbations
Mode de vie
Alimentation déséquilibrée
Facteurs environnementaux
Toxines
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{
"@type": "Question",
"name": "Comment prévenir les maladies liées aux interactions protéiques ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent réduire les risques."
}
},
{
"@type": "Question",
"name": "Les dépistages sont-ils utiles pour les troubles protéiques ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des dépistages précoces peuvent aider à identifier des risques de maladies génétiques."
}
},
{
"@type": "Question",
"name": "L'éducation sur les interactions protéiques est-elle importante ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, comprendre les interactions peut aider à prévenir des maladies et à promouvoir la santé."
}
},
{
"@type": "Question",
"name": "Les vaccins influencent-ils les interactions protéiques ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccins peuvent moduler les interactions immunitaires, renforçant la réponse du corps."
}
},
{
"@type": "Question",
"name": "Comment le stress affecte-t-il les interactions protéiques ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress peut altérer les interactions protéiques, affectant la santé globale et le bien-être."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent les interactions protéiques ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les inhibiteurs de protéines ou des anticorps monoclonaux sont utilisés."
}
},
{
"@type": "Question",
"name": "Comment la thérapie génique influence-t-elle les interactions ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut corriger des mutations, rétablissant ainsi des interactions protéiques normales."
}
},
{
"@type": "Question",
"name": "Les inhibiteurs de protéines sont-ils efficaces ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent bloquer des interactions spécifiques, offrant des options thérapeutiques."
}
},
{
"@type": "Question",
"name": "Comment les traitements ciblent-ils les motifs d'interaction ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils visent à modifier ou à bloquer des motifs spécifiques pour restaurer la fonction cellulaire."
}
},
{
"@type": "Question",
"name": "Les thérapies combinées sont-elles bénéfiques ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent cibler plusieurs interactions protéiques, améliorant l'efficacité du traitement."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des interactions anormales ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des cancers, des maladies neurodégénératives ou des troubles métaboliques."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non."
}
},
{
"@type": "Question",
"name": "Comment les interactions affectent-elles le vieillissement ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des interactions protéiques altérées peuvent accélérer le vieillissement cellulaire et tissulaire."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles liées aux interactions ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des interactions anormales peuvent déclencher des réponses auto-immunes dans l'organisme."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils causés par des interactions ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des interactions protéiques défectueuses peuvent entraîner des déséquilibres métaboliques."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de troubles protéiques ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme la génétique, l'environnement et le mode de vie influencent le risque."
}
},
{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la stabilité et la fonction des interactions protéiques."
}
},
{
"@type": "Question",
"name": "Les infections virales influencent-elles les interactions ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales peuvent perturber les interactions protéiques, augmentant les risques."
}
},
{
"@type": "Question",
"name": "Le mode de vie peut-il affecter les interactions protéiques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation déséquilibrée et le manque d'exercice peuvent altérer les interactions."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des toxines ou des polluants peuvent affecter les interactions protéiques et la santé."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 17/04/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Chemistry-BMC, Uppsala University, Box 576, SE-751 23 Uppsala, Sweden. Electronic address: Yiva.ivarson@kemi.uu.se.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
Centre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology Sydney, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
Centre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology Sydney, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
Department of Medical Biochemistry and Microbiology, Uppsala University, BMC Box 582, SE-75123 Uppsala, Sweden. Electronic address: Per.Jemth@imbim.uu.se.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Dynamics of Macromolecular Assembly, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Dynamics of Macromolecular Assembly, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
Publications dans "Motifs et domaines d'intéraction protéique" :
2 publications dans cette catégorie
Affiliations :
Structural Biology and NMR Laboratory and The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Centre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology Sydney, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Centre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology Sydney, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Computational and Structural Biology Laboratory, Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi, 110078, India.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Computational and Structural Biology Laboratory, Division of Biotechnology, Netaji Subhas Institute of Technology, Dwarka, New Delhi, 110078, India.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Computational and Structural Biology Laboratory, Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi, 110078, India.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Computational and Structural Biology Laboratory, Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi, 110078, India. sbhatnagar@nsut.ac.in.
Computational and Structural Biology Laboratory, Division of Biotechnology, Netaji Subhas Institute of Technology, Dwarka, New Delhi, 110078, India. sbhatnagar@nsut.ac.in.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
School of Life Sciences, University of Technology Sydney, Sydney, New South Wales 2007, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
School of Life Sciences, University of Technology Sydney, Sydney, New South Wales 2007, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Height, Australian Centre for Neutron Scattering, New South Wales 2234, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
School of Life Sciences, University of Technology Sydney, Sydney, New South Wales 2007, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular Sciences, Macquarie University, New South Wales 2109, Australia.
Publications dans "Motifs et domaines d'intéraction protéique" :
Lingual microcystic lymphatic malformations (LMLMs) are rare congenital vascular malformations presenting as clusters of cysts filled with lymph fluid or blood. Even small well-limited lesions can be ...
This is a randomized, multicentric study using an individually randomized stepped-wedge design over 24 weeks to evaluate topical application of a 1 mg/mL sirolimus solution once daily, on LMLM, versus...
Given the disappointing state of current treatment options in LMLMs, topical sirolimus could become firstline therapy in treating LMLMs if its efficacy and safety were to be demonstrated....
ClinicalTrials.gov NCT04128722 . Registered on 24 September 2019. EudraCT: EUCTR2019-001530-33-FR Sponsor (University Hospital Center of Tours - CHRU Tours): DR190041-TOPGUN French regulatory authorit...
Most of the Brazilian population relies on public healthcare and stroke is a major cause of disability in this country of continental dimensions. There is limited information about access to rehabilit...
To provide comprehensive information about Access to Rehabilitation After discharge from public hospitals in Brazil (AReA study), up to 6 months after stroke....
The present study intends to collect information from 17 public health centers in 16 Brazilian cities in the 5 macroregions of the country. Each center will include 36 participants (...
The study is ongoing. Recruitment started on January 31...
The AReA study will fill a gap in knowledge about access to stroke rehabilitation in the public health system in different Brazilian regions....
Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive tumor with a low rate of metastatic disease. Previous series have shown a superiority of Mohs micrographic surgery (MMS) compared with wi...
The purpose of the current study was to examine the outcome of surgical treatment of primary DFSP of the trunk and extremities....
We reviewed 236 patients (115 females, 121 males, mean age 41 ± 15 years) undergoing MMS (n = 81, 34%) or WLE (n = 155, 66%) to treat a primary DFSP. Mean tumor size and follow-up was 4 ± 2 cm and 7 y...
There was no difference (p > 0.05) in patient age, sex, tumor size, negative margin excision, or history of a previous inadvertent excision between patients who underwent WLE and those undergoing MMS....
There was no difference in oncologic outcome comparing MMS with WLE for DFSP outside the head and neck. The goal of treatment for DFSP is to achieve a negative margin, regardless of surgical treatment...
Acute lower limb ischemia (ALI) is a limb- and potentially life-threatening condition which requires urgent evaluation and treatment. Contemporary data on optimal therapy and prognosis of ALI are lack...
The proposed study is a prospective, international, multicenter, observational study on ALI (PROMOTE-ALI) (ClinicalTrials.gov - NCT05138679). Patients with ALI (Rutherford classification grade I -III)...
ALI remains a challenging condition and due to the heterogeneous etiology, clinical presentation and treatment strategies, a large multicenter study on this topic is needed to gain contemporary data o...
As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudie...
BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18-80 years with BAD-related stroke within 72 h after symptom onset. Initial clinic...
BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterio...
Narrowband ultraviolet B (NB-UVB) phototherapy is commonly prescribed for patients with moderate-to-severe atopic eczema (AE). The efficacy of NB-UVB, however, has not yet properly been established, a...
A pragmatic, multicenter, PROBE trial will be performed with 1:1 randomization of 316 adult patients with moderate-to-severe AE who have inadequate disease control with topical therapy and who are eli...
The UPDATE trial aims to provide high-quality evidence regarding the (cost-)effectiveness and safety of NB-UVB phototherapy in moderate-to-severe AE patients. Challenges that are addressed in the prot...
ClinicalTrials.gov NCT05704205. Registered on December 8, 2022....
Epidemiological data on cerebral venous thrombosis in China are still lacking at present on the aspects of incidence, recurrence, risk factors, and so on. Herein, we aimed to fill the gap, based on th...
Rectal cancer is a common cancer worldwide. Surgery for rectal cancer with low anterior resection often includes the formation of a temporary protective loop ileostomy. The temporary ostomy is later r...
The present multicenter, double-blinded, randomized, controlled study will compare standard suture closure of the abdominal wall in loop ileostomy reversal with retromuscular synthetic mesh at the sto...
This double-blinded randomized controlled superiority study will compare retromuscular synthetic mesh during the closure of loop ileostomy to standard care. If this study can show a lower frequency of...
ClinicalTrials.gov NCT03720262. Registered on October 25, 2018....
Multicenter contemporary data describing short-term outcomes after initial interventions of neonates with pulmonary atresia with intact ventricular septum (PA-IVS) are limited. This multicenter study ...
Neonates with PA-IVS who underwent surgical or catheter intervention between 2009 and 2019 in 19 centers were reviewed. Risk factors for MACE, defined as cardiopulmonary resuscitation, mechanical circ...
We reviewed 279 neonates: 79 (28%) underwent right ventricular decompression, 151 (54%) underwent systemic-to-pulmonary shunt or ductal stent placement only, 36 (13%) underwent right ventricular decom...
In a multicenter cohort, 1 in 5 neonates with PA-IVS experienced MACE after their initial intervention. Patients with 2 major coronary artery stenoses or lower weight at the time of the initial proced...
Cases of Toxoplasma reactivation or more severe primary infection have been reported in patients receiving immunosuppressive (IS) treatment for autoimmune diseases (AID). The purpose of this study was...
A multicenter descriptive study was conducted using data from the French National Reference Center for Toxoplasmosis (NRCT) that received DNA extracts or strains isolated from patients, associated wit...
61 cases were collected: 25 retrieved by the NRCT and by a call for observations and 36 from a literature review. Half of the cases were attributed to reactivation (50.9%), and most of cases (49.2%) w...
Although this remains a rare condition, clinicians should be aware for the management of patients and for the choice of IS treatment....