Comment identifier un domaine d'interaction protéique ?

L'identification se fait par des méthodes bioinformatiques et des expériences de biologie moléculaire.

Quels tests sont utilisés pour analyser les interactions protéiques ?

Les tests incluent le co-immunoprécipitation et les essais de double hybride.

Les motifs d'interaction peuvent-ils être prédits ?

Oui, des outils bioinformatiques permettent de prédire les motifs d'interaction dans les protéines.

Quels marqueurs indiquent une interaction protéique ?

Des changements de conformation ou des complexes protéiques stables peuvent indiquer une interaction.

Comment les mutations affectent-elles les interactions protéiques ?

Les mutations peuvent altérer la structure des motifs, perturbant ainsi les interactions normales.

Quels symptômes indiquent une dysfonction protéique ?

Des symptômes variés comme la fatigue, des troubles métaboliques ou des maladies auto-immunes.

Les interactions protéiques peuvent-elles causer des maladies ?

Oui, des interactions anormales peuvent contribuer à des maladies comme le cancer ou Alzheimer.

Comment les maladies génétiques affectent-elles les interactions ?

Elles peuvent entraîner des défauts dans les motifs d'interaction, perturbant les fonctions cellulaires.

Quels signes cliniques sont liés aux troubles d'interaction ?

Des signes comme l'inflammation, la douleur ou des anomalies neurologiques peuvent apparaître.

Les infections peuvent-elles perturber les interactions protéiques ?

Oui, certains pathogènes modifient les interactions protéiques pour favoriser leur survie.

Comment prévenir les maladies liées aux interactions protéiques ?

Une alimentation équilibrée et un mode de vie sain peuvent réduire les risques.

Les dépistages sont-ils utiles pour les troubles protéiques ?

Oui, des dépistages précoces peuvent aider à identifier des risques de maladies génétiques.

L'éducation sur les interactions protéiques est-elle importante ?

Oui, comprendre les interactions peut aider à prévenir des maladies et à promouvoir la santé.

Les vaccins influencent-ils les interactions protéiques ?

Oui, les vaccins peuvent moduler les interactions immunitaires, renforçant la réponse du corps.

Comment le stress affecte-t-il les interactions protéiques ?

Le stress peut altérer les interactions protéiques, affectant la santé globale et le bien-être.

Quels traitements ciblent les interactions protéiques ?

Des médicaments comme les inhibiteurs de protéines ou des anticorps monoclonaux sont utilisés.

Comment la thérapie génique influence-t-elle les interactions ?

Elle peut corriger des mutations, rétablissant ainsi des interactions protéiques normales.

Les inhibiteurs de protéines sont-ils efficaces ?

Oui, ils peuvent bloquer des interactions spécifiques, offrant des options thérapeutiques.

Comment les traitements ciblent-ils les motifs d'interaction ?

Ils visent à modifier ou à bloquer des motifs spécifiques pour restaurer la fonction cellulaire.

Les thérapies combinées sont-elles bénéfiques ?

Oui, elles peuvent cibler plusieurs interactions protéiques, améliorant l'efficacité du traitement.

Quelles complications peuvent survenir avec des interactions anormales ?

Des complications comme des cancers, des maladies neurodégénératives ou des troubles métaboliques.

Les complications sont-elles réversibles ?

Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non.

Comment les interactions affectent-elles le vieillissement ?

Des interactions protéiques altérées peuvent accélérer le vieillissement cellulaire et tissulaire.

Les maladies auto-immunes sont-elles liées aux interactions ?

Oui, des interactions anormales peuvent déclencher des réponses auto-immunes dans l'organisme.

Les troubles métaboliques sont-ils causés par des interactions ?

Oui, des interactions protéiques défectueuses peuvent entraîner des déséquilibres métaboliques.

Quels facteurs augmentent le risque de troubles protéiques ?

Des facteurs comme la génétique, l'environnement et le mode de vie influencent le risque.

Le vieillissement est-il un facteur de risque ?

Oui, le vieillissement peut affecter la stabilité et la fonction des interactions protéiques.

Les infections virales influencent-elles les interactions ?

Certaines infections virales peuvent perturber les interactions protéiques, augmentant les risques.

Le mode de vie peut-il affecter les interactions protéiques ?

Oui, une alimentation déséquilibrée et le manque d'exercice peuvent altérer les interactions.

Les facteurs environnementaux jouent-ils un rôle ?

Oui, des toxines ou des polluants peuvent affecter les interactions protéiques et la santé.

Motifs et domaines d'intéraction protéique - Informations médicales vérifiées

Physical function across the lifespan in adults with multiple sclerosis: An application of the Short Physical Performance Battery.

May 2023

DOI: 10.1016/j.msard.2023.104624 PMID: 37004273

Multiple sclerosis (MS) typically has its onset in early and middle adulthood, but the population is steadily becoming more dominated by older adults. One of the primary consequences of both MS and ag... The study involved secondary analysis of cross-sectional data from multiple studies. Ambulatory adults with MS who were relapse-free for the last 30 days were recruited, and controls were recruited ba... The two-way ANOVA indicated a main effect of MS status (F(5,500)=34.74, p<.01, η... Overall, MS status and aging have additive effects on physical function, and the summary SPPB score may be driven by a specific component within each age group. SPPB scores may be driven more by mobil...

Humans Aged Adult Longevity Cross-Sectional Studies +3 autres

Physical performance tasks were linked to the PROMIS physical function metric in patients undergoing hemodialysis.

07 2023

DOI: 10.1016/j.jclinepi.2023.04.007 PMID: 37105321

To investigate whether a multi-item performance outcome measure, the physical performance test (PPT), can be calibrated to a common scale with patient-reported outcome measures, using the Patient-Repo... We analyzed baseline data (N = 1,113) from the CONVINCE study, an international trial in end-stage kidney disease patients comparing high-dose hemodiafiltration with high-flux hemodialysis. Assumption... Although some evidence for multidimensionality was found, classical test statistics (Cronbach's Alpha = 0.93), Mokken (Loevinger's H = 0.50), and bifactor analysis (explained common variance = 0.65) i... We found preliminary evidence that the PPT can be linked to the PROMIS PF metric in hemodialysis patients, enabling group comparisons across patient-reported outcome and performance outcome measures. ...

Humans Surveys and Questionnaires Physical Functional Performance Renal Dialysis Patient Reported Outcome Measures +1 autres

Gait parameters, functional performance and physical activity in active and inactive Juvenile Idiopathic Arthritis.

10 2022

DOI: 10.1016/j.gaitpost.2022.09.080 PMID: 36191581

Children with Juvenile Idiopathic Arthritis (JIA) may adopt different movement patterns and participate in physical activity during different states of disease.... Which specific features of gait and physical function performance differ among children with active or inactive JIA compared to healthy children?... Forty-three children participated (14.5 ± 4.2 yrs; 60 % female). 3D-motion analysis methods were coupled with force measures from an instrumented treadmill captured gait mechanical measures. The 30-se... Compared to healthy controls children with active and inactive JIA had worse outcomes (12-21 % slower self-selected and fast walking speeds, 28-34 % slower stair navigation times, 28 % fewer chair ris... Gait speed, specific load-bearing functional tasks and leg stiffness features of gait may be informative 'functional biomarkers' for assessing JIA burden and tracking treatment efficacy. Additional pr...

Child Humans Female Male Arthritis, Juvenile +7 autres

A Data Analytics Approach to Assess the Functional and Physical Performance of Female Soccer Players: A Cohort Design.

22 07 2022

DOI: 10.3390/ijerph19158941 PMID: 35897308

The aim of this study was twofold: (i) to observe the individual results of fitness status [countermovement jump (CMJ)], hop test, linear sprinting time, stride frequency, stride distance, force-power... The study followed a cohort design. Sixteen female soccer players competing in the second division of the Spanish league were monitored during the first days of the pre-season. These players were eval...

Athletic Performance Data Science Exercise Test Female Humans +3 autres

Velocity walking test: Selective influences on physical functional performance for better tracking of older women.

06 2023

DOI: 10.1016/j.archger.2023.104962 PMID: 36804697

To examine the selective influences of changes in walking test capability on physical functional performance (COD speed, COD deficit, linear sprint speed, chair stand test, handgrip strength, and unlo... The performances of eighty women ((age, 64.7 ± 3.38 y; body mass, 66.3 ± 11.15 kg; height, 153.5 ± 5.71 cm, BMI, 28.08 ± 4.00 kg/m... Strength and conditioning coaches and professionals involved with older women should consider the COD deficit (i.e., linear velocity minus change of direction velocity), as a complementary measure to ...

Aged Female Humans Exercise Test Hand Strength +7 autres

Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity.

05 2023

DOI: 10.1007/s00467-022-05758-0 PMID: 36315277

History of chronic kidney disease and kidney transplantation is known to influence physical performance capacity. The aim of this study was to compare the physical performance of pediatric kidney tran... Twenty-four pediatric kidney transplant recipients (62.5% boys) were tested at a median age of 10.8 years. Physical performance capacity was tested with a test set including six different components a... The physical performance capacity in pediatric kidney transplant recipients was lower compared to healthy controls. Surprisingly, no statistically significant correlation was found between graft funct... The physical performance of pediatric kidney transplant recipients is reduced, especially in those with congenital nephrotic syndrome. Clinical parameters, including graft function, did not predict ph...

Male Humans Child Female Kidney Transplantation +5 autres

Assessing individual-level measurement precision of the Short Physical Performance Battery using the test information function.

01 03 2023

DOI: 10.1097/MRR.0000000000000557 PMID: 36591991

The Short Physical Performance Battery (SPPB) is a commonly used tool to assess lower extremity function, composed of three assessments (standing balance, gait speed, and chair stand). While its valid...

Aged Humans Walking Speed Lower Extremity Psychometrics +1 autres

Investigation of the correlation between knee joint position sense and physical functional performance in individuals with transtibial amputation.

01 Oct 2023

DOI: 10.1097/PXR.0000000000000206 PMID: 36723386

In individuals with transtibial amputation, the distal part of the lower extremity is lost. Therefore, the knee joint is of greater importance to be able to provide physical performance. The aim of th... The study included 21 subjects with transtibial amputation. A digital inclinometer was used to evaluate the joint position sense of the amputated side knee joint. The timed up and go test, the 4-squar... The mean age of the participants was 52.52 ± 15.68 years. The mean of the error in knee joint position sense was 5.33 degree (standard deviation = 3.08 degree). The error in knee joint position sense ... The knee joint position sense on the amputated side was found to be associated with physical functional performance in individuals with transtibial amputation. Residual limb knee joint position sense ...

Humans Adult Middle Aged Aged Postural Balance +6 autres

Impact of a multimodal effort re-education programme on functionality, physical performance, and functional capacity in cancer patients with dyspnoea: a randomised experimental study.

06 Sep 2024

DOI: 10.1007/s00520-024-08852-1 PMID: 39237780

In recent years, there has been a significant increase in the survival rates of cancer patients. However, this has also led to an increase in side effects, such as dyspnoea, which can negatively impac... Experimental, prospective, longitudinal, randomised study with a parallel fixed-assignment scheme (CG-IG). The patients were selected from the Medical Oncology Service of the University Hospital Compl... The study sample consisted of 182 patients, with 12 excluded, resulting in a final sample size of n = 170. Sex distribution (CG: 52.9% male and 47.1% female; IG: 49.4% male and 50.6% female). The prim... The results of this study support the beneficial effects of an exercise re-education programme, carried out by an interdisciplinary team in improving the autonomy of oncology patients with dyspnoea.... The clinical trial was registered in ClinicalTrials.gov (NCT04186754). (03 September 2019)....

Humans Male Female Dyspnea Middle Aged +8 autres

Effect of Long-term Exercise Training on Physical Performance and Cardiorespiratory Function in Adults With CKD: A Randomized Controlled Trial.

01 2023

DOI: 10.1053/j.ajkd.2022.06.008 PMID: 35944747

The safety and efficacy of long-term exercise training in reducing physical functional loss in older adults with advanced CKD and comorbidity is uncertain.... Multicenter, parallel group, randomized controlled trial.... Adults 55 years and older with estimated glomerular filtration rate (eGFR) of 15 to <45 mL/min/1.73 m... Twelve months of in-center supervised exercise training incorporating majority aerobic but also muscle strengthening activities or a group health education control intervention, randomly assigned in 1... Primary outcomes were cardiorespiratory fitness and submaximal gait at 6 and 12 months quantified by peak oxygen consumption (Vo... Among 99 participants, the mean age was 68 years, 62% were African American, and the mean eGFR was 33 mL/min/1.73 m... Planned sample size was not reached. Loss to follow-up and dropout were greater than anticipated.... Among adults aged ≥55 years with CKD stages 3b-4 and a high level of medical comorbidity, a 12-month program of in-center aerobic and resistance exercise training was safe and associated with improvem... Government grants (National Institutes of Health).... Registered at ClinicalTrials.gov with study number NCT01462097....

Humans Aged Postural Balance Time and Motion Studies Exercise +3 autres

Motifs et domaines d'intéraction protéique : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Domaine B30.2-SPRY

Domaine BTB-POZ

Superfamille des domaines de mort

Domaines FERM

Domaines MYND

Domaines PDZ

Domaines à doigts de zinc de type RING

Domaine d'homologie SRC

Motif stérile alpha

Domaine Tudor

Domaines WW

Domaine d'activation et de recrutement des caspases

Domaine de mort

Domaine effecteur de mort

Domaine pyrine

Auteurs principaux

Sources (10000 au total)