Titre : Inhibiteurs de la 5-alpha réductase

Inhibiteurs de la 5-alpha réductase : Questions médicales fréquentes

Termes MeSH sélectionnés :

Cancer-Associated Fibroblasts
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"https://questionsmedicales.fr/mesh/D058891?mesh_terms=Cancer-Associated+Fibroblasts&page=5#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Inhibiteurs de la 5-alpha réductase", "description": "Quels sont les facteurs de risque de l'hyperplasie bénigne ?\nLa génétique joue-t-elle un rôle dans la calvitie ?\nLe mode de vie influence-t-il la DHT ?\nL'âge est-il un facteur de risque pour la calvitie ?", "url": "https://questionsmedicales.fr/mesh/D058891?mesh_terms=Cancer-Associated+Fibroblasts&page=5#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une hyperplasie bénigne de la prostate ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un examen physique, des tests urinaires et un dosage du PSA aident au diagnostic." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer la DHT ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Un dosage sanguin de la DHT peut être effectué pour évaluer les niveaux hormonaux." } }, { "@type": "Question", "name": "Quels symptômes indiquent un besoin d'inhibiteurs ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes urinaires comme des difficultés à uriner peuvent indiquer un besoin." } }, { "@type": "Question", "name": "Comment évaluer l'efficacité des inhibiteurs ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "L'efficacité est évaluée par l'amélioration des symptômes et la réduction du PSA." } }, { "@type": "Question", "name": "Quels sont les symptômes de l'hyperplasie bénigne de la prostate ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent des mictions fréquentes, un jet urinaire faible et des douleurs." } }, { "@type": "Question", "name": "La calvitie est-elle un symptôme lié à la DHT ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la DHT est impliquée dans la perte de cheveux androgénétique chez les hommes." } }, { "@type": "Question", "name": "Quels effets secondaires peuvent survenir ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Les effets secondaires incluent la dysfonction érectile, la réduction de la libido et la gynécomastie." } }, { "@type": "Question", "name": "Les inhibiteurs affectent-ils la libido ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains patients peuvent éprouver une diminution de la libido en raison des inhibiteurs." } }, { "@type": "Question", "name": "Peut-on prévenir l'hyperplasie bénigne de la prostate ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation saine et un mode de vie actif peuvent aider à réduire le risque." } }, { "@type": "Question", "name": "Y a-t-il des mesures préventives pour la calvitie ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des soins capillaires appropriés et des traitements précoces peuvent aider à prévenir la calvitie." } }, { "@type": "Question", "name": "Les inhibiteurs peuvent-ils être utilisés préventivement ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Ils ne sont généralement pas utilisés en prévention, mais pour traiter des symptômes existants." } }, { "@type": "Question", "name": "Quels changements de mode de vie sont recommandés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée, l'exercice régulier et la gestion du stress sont conseillés." } }, { "@type": "Question", "name": "Quels médicaments sont des inhibiteurs de la 5-alpha réductase ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Les médicaments comme le finastéride et le dutastéride sont des inhibiteurs connus." } }, { "@type": "Question", "name": "Comment les inhibiteurs agissent-ils ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Ils bloquent la conversion de la testostérone en DHT, réduisant ainsi les symptômes." } }, { "@type": "Question", "name": "Quelle est la durée du traitement ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement peut durer plusieurs mois avant d'observer des résultats significatifs." } }, { "@type": "Question", "name": "Les inhibiteurs sont-ils efficaces pour la calvitie ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent ralentir la perte de cheveux et favoriser la repousse chez certains patients." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec les inhibiteurs ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme la dysfonction érectile et des troubles hormonaux peuvent survenir." } }, { "@type": "Question", "name": "Les inhibiteurs augmentent-ils le risque de cancer ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des études montrent des résultats contradictoires, mais un suivi médical est recommandé." } }, { "@type": "Question", "name": "Comment gérer les effets secondaires ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Consulter un médecin pour ajuster le traitement ou envisager des alternatives est conseillé." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles après l'arrêt du traitement, mais pas toutes." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque de l'hyperplasie bénigne ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "L'âge, l'obésité et des antécédents familiaux augmentent le risque d'hyperplasie bénigne." } }, { "@type": "Question", "name": "La génétique joue-t-elle un rôle dans la calvitie ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la génétique est un facteur majeur dans la perte de cheveux androgénétique." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il la DHT ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter les niveaux de DHT." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque pour la calvitie ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque de calvitie augmente avec l'âge, surtout chez les hommes." } } ] } ] }

Sources (10000 au total)

Oral Squamous Cell Carcinoma-Derived ANGPTL3 Induces Cancer Associated Fibroblastic Phenotypes in Surrounding Fibroblasts.

Angiopoietin-like proteins (ANGPTLs) have emerged as both important regulator of lipid and glucose metabolism as well as insulin sensitivity. In particular, ANGPTL3 activity is one of the most importa... For our study, we used hTERT-hNOFs to replace CAFs by coculturing them with oral squamous cell carcinoma (OSCC) cells. We did a microarray dataset analysis to investigate what factors secreted from OS... ANGPTL3 has the most secreted factor derived from various oral cancer cells. To investigate the role of ANGPTL3 in CAFs, we treated rhANGPTL3 in hTERT-hNOFs. The fibroblasts showed an increase of tumo... In conclusion, our study reports the first evidence that ANGPTL3 plays a crucial role in tumor microenvironments by inducing CAF. Therefore, targeting ANGPTL3 may be promising treatment strategy for C...

Breast cancer-derived exosomal lncRNA SNHG14 induces normal fibroblast activation to cancer-associated fibroblasts via the EBF1/FAM171A1 axis.

Exosomes released from cancer cells can activate normal fibroblasts (NFs) into cancer-associated fibroblasts (CAFs), which promotes cancer development. Our study aims to explore the role and potential... Adjacent normal tissues, cancerous and serum specimens were gathered in breast cancer patients. Exosomes and NFs were separated from breast cancer cells (SKBR-3) and normal tissues of patients, respec... SNHG14 and FAM171A1 were upregulated in breast cancer. Exosomes secreted by SKBR-3 cells induced NFs activation in CAFs, as indicated by upregulating CAFs marker levels and facilitated cell viability ... Breast cancer-derived exosomal SNHG14 contributed to NFs transformation into CAFs by the EBF1/FAM171A1 axis....

Cancer-Associated Fibroblasts Are Key Determinants of Cancer Cell Invasion in the Earliest Stage of Colorectal Cancer.

Improving clinical management of early stage colorectal cancers (T1CRCs) requires a better understanding of their underlying biology. Accumulating evidence shows that cancer-associated fibroblasts (CA... Primary T1CAFs and patient-matched normal fibroblasts (NFs) were isolated from endoscopic biopsy specimens of histologically confirmed T1CRCs and normal mucosa, respectively. The impact of T1CAFs and ... In 3-dimensional multicellular cultures, matrix invasion of T1CRC organoids was induced by T1CAFs, but not by matched NFs. Enhanced T1CRC invasion was accompanied by T1CAF-induced ECM remodeling and u... Already in the earliest stage of CRC, cancer cell invasion is promoted by CAFs via direct interactions with epithelial cancer cells and stage-specific, cathepsin H-dependent ECM remodeling. RNA sequen...

Investigating the complex interplay between fibroblast activation protein α-positive cancer associated fibroblasts and the tumor microenvironment in the context of cancer immunotherapy.

This study investigates the role of Fibroblast Activation Protein (FAP)-positive cancer-associated fibroblasts (FAP+CAF) in shaping the tumor immune microenvironment, focusing on its association with ... Utilizing immunohistochemistry, we observed elevated FAP+CAF density in metastatic versus primary renal cell carcinoma (RCC) tumors, with higher FAP+CAF correlating with increased T cell infiltration ... Analysis of immune cell subsets in FAP+CAF-rich stromal areas further revealed significant correlations between FAP+ stroma and various T cell types, particularly in RCC and non-small cell lung cancer... These findings underscore the complexity of tumor biology and the necessity for personalized therapeutic and patient enrichment approaches. The insights gathered from FAP+CAF prevalence, immune infilt...