Inhibiteurs de la 5-alpha réductase : Questions médicales fréquentes
Nom anglais: 5-alpha Reductase Inhibitors
Descriptor UI:D058891
Tree Number:D27.505.696.399.450.855.200
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"name": "Diagnostic",
"headline": "Diagnostic sur Inhibiteurs de la 5-alpha réductase",
"description": "Comment diagnostiquer une hyperplasie bénigne de la prostate ?\nQuels tests sont utilisés pour évaluer la DHT ?\nQuels symptômes indiquent un besoin d'inhibiteurs ?\nComment évaluer l'efficacité des inhibiteurs ?",
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"name": "Symptômes",
"headline": "Symptômes sur Inhibiteurs de la 5-alpha réductase",
"description": "Quels sont les symptômes de l'hyperplasie bénigne de la prostate ?\nLa calvitie est-elle un symptôme lié à la DHT ?\nQuels effets secondaires peuvent survenir ?\nLes inhibiteurs affectent-ils la libido ?",
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"headline": "Prévention sur Inhibiteurs de la 5-alpha réductase",
"description": "Peut-on prévenir l'hyperplasie bénigne de la prostate ?\nY a-t-il des mesures préventives pour la calvitie ?\nLes inhibiteurs peuvent-ils être utilisés préventivement ?\nQuels changements de mode de vie sont recommandés ?",
"url": "https://questionsmedicales.fr/mesh/D058891?page=2#section-prévention"
},
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"name": "Traitements",
"headline": "Traitements sur Inhibiteurs de la 5-alpha réductase",
"description": "Quels médicaments sont des inhibiteurs de la 5-alpha réductase ?\nComment les inhibiteurs agissent-ils ?\nQuelle est la durée du traitement ?\nLes inhibiteurs sont-ils efficaces pour la calvitie ?",
"url": "https://questionsmedicales.fr/mesh/D058891?page=2#section-traitements"
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"headline": "Complications sur Inhibiteurs de la 5-alpha réductase",
"description": "Quelles complications peuvent survenir avec les inhibiteurs ?\nLes inhibiteurs augmentent-ils le risque de cancer ?\nComment gérer les effets secondaires ?\nLes complications sont-elles réversibles ?",
"url": "https://questionsmedicales.fr/mesh/D058891?page=2#section-complications"
},
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"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Inhibiteurs de la 5-alpha réductase",
"description": "Quels sont les facteurs de risque de l'hyperplasie bénigne ?\nLa génétique joue-t-elle un rôle dans la calvitie ?\nLe mode de vie influence-t-il la DHT ?\nL'âge est-il un facteur de risque pour la calvitie ?",
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"@type": "Question",
"name": "Comment diagnostiquer une hyperplasie bénigne de la prostate ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un examen physique, des tests urinaires et un dosage du PSA aident au diagnostic."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer la DHT ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un dosage sanguin de la DHT peut être effectué pour évaluer les niveaux hormonaux."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent un besoin d'inhibiteurs ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes urinaires comme des difficultés à uriner peuvent indiquer un besoin."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'efficacité des inhibiteurs ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité est évaluée par l'amélioration des symptômes et la réduction du PSA."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes de l'hyperplasie bénigne de la prostate ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des mictions fréquentes, un jet urinaire faible et des douleurs."
}
},
{
"@type": "Question",
"name": "La calvitie est-elle un symptôme lié à la DHT ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la DHT est impliquée dans la perte de cheveux androgénétique chez les hommes."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires peuvent survenir ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires incluent la dysfonction érectile, la réduction de la libido et la gynécomastie."
}
},
{
"@type": "Question",
"name": "Les inhibiteurs affectent-ils la libido ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains patients peuvent éprouver une diminution de la libido en raison des inhibiteurs."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir l'hyperplasie bénigne de la prostate ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation saine et un mode de vie actif peuvent aider à réduire le risque."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives pour la calvitie ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des soins capillaires appropriés et des traitements précoces peuvent aider à prévenir la calvitie."
}
},
{
"@type": "Question",
"name": "Les inhibiteurs peuvent-ils être utilisés préventivement ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils ne sont généralement pas utilisés en prévention, mais pour traiter des symptômes existants."
}
},
{
"@type": "Question",
"name": "Quels changements de mode de vie sont recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée, l'exercice régulier et la gestion du stress sont conseillés."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont des inhibiteurs de la 5-alpha réductase ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les médicaments comme le finastéride et le dutastéride sont des inhibiteurs connus."
}
},
{
"@type": "Question",
"name": "Comment les inhibiteurs agissent-ils ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils bloquent la conversion de la testostérone en DHT, réduisant ainsi les symptômes."
}
},
{
"@type": "Question",
"name": "Quelle est la durée du traitement ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut durer plusieurs mois avant d'observer des résultats significatifs."
}
},
{
"@type": "Question",
"name": "Les inhibiteurs sont-ils efficaces pour la calvitie ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent ralentir la perte de cheveux et favoriser la repousse chez certains patients."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec les inhibiteurs ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme la dysfonction érectile et des troubles hormonaux peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les inhibiteurs augmentent-ils le risque de cancer ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études montrent des résultats contradictoires, mais un suivi médical est recommandé."
}
},
{
"@type": "Question",
"name": "Comment gérer les effets secondaires ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Consulter un médecin pour ajuster le traitement ou envisager des alternatives est conseillé."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles après l'arrêt du traitement, mais pas toutes."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de l'hyperplasie bénigne ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge, l'obésité et des antécédents familiaux augmentent le risque d'hyperplasie bénigne."
}
},
{
"@type": "Question",
"name": "La génétique joue-t-elle un rôle dans la calvitie ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la génétique est un facteur majeur dans la perte de cheveux androgénétique."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il la DHT ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter les niveaux de DHT."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour la calvitie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de calvitie augmente avec l'âge, surtout chez les hommes."
}
}
]
}
]
}
The most prescribed class of medications for benign prostatic hyperplasia (BPH) is α-blockers (ABs). However, the cardiovascular safety profile of these medications among patients with BPH is not well...
To compare the safety of ABs vs 5-α reductase inhibitors (5-ARIs) for risk of adverse cardiovascular outcomes....
This active comparator, new-user cohort study was conducted using insurance claims data from a 20% random sample of Medicare beneficiaries from 2007 to 2019 to evaluate the 1-year risk of adverse card...
Exposure was defined by a qualifying prescription fill for an AB or 5-ARI after at least 12 months without a prescription for these drug classes....
Follow-up began at a qualified refill for the study drug. Primary study outcomes were hospitalization for heart failure (HF), composite major adverse cardiovascular events (MACE; hospitalization for s...
Among 189 868 older adult males, there were 163 829 patients initiating ABs (mean [SD] age, 74.6 [6.2] years; 579 American Indian or Alaska Native [0.4%], 5890 Asian or Pacific Islander [3.6%], 9179 B...
These results suggest that ABs may be associated with an increased risk of adverse cardiovascular outcomes compared with 5-ARIs. If replicated with more detailed confounder data, these results may hav...
To investigate the effect of 5-α reductase inhibitor on the expression of inflammation-related cytokines in Benign prostatic hyperplasia (BPH) specimens after transurethral prostatic resection (TUR-P)...
We prospectively examined the expression of inflammation-related cytokines with immunohistochemistry in the paraffin blocks of 60 patients who underwent TUR-P. 30 cases in the 5-α-reductase inhibitor ...
There was no statistical difference in the location, range and degree of inflammation between the two groups (P > 0.05). When IL-17 expression was low, there was statistical difference between the two...
5-α Reductase inhibitor can inhibit the expression of Bcl-2 in prostatic tissue and the inflammatory response related to T-helper cell 1 (Th1) and T-helper cell 2 (Th2) cells. However, it did not affe...
Five-alpha reductase inhibitors (5αRIs) are used to treat benign prostatic hyperplasia (BPH). However, the cardiovascular effects of 5αRIs remain poorly understood. The study objective was to compare ...
Using the Clinical Practice Research Datalink linked with hospitalization and vital statistics data, we conducted a population-based cohort study among patients newly diagnosed with BPH. We defined ex...
Our cohort included 94,440 men with incident BPH. A total of 3893 hospitalizations for heart failure occurred over 527,660 person-years of follow-up (incidence rate 7.38; 95% CI, 7.15-7.61, per 1000 p...
The use of 5αRIs was not associated with an increased risk of hospitalization for heart failure, myocardial infarction, stroke, or cardiovascular death compared with non-use....
5-alpha reductase inhibitors (5-ARIs) are commonly used and widely available, with benefits observed from their effect on androgen signalling. Their effect relies on the inhibition of the 5-alpha redu...
Finasteride and dutasteride are 5-alpha reductase selective inhibitors (5ARIs). They were introduced as therapeutic agents for the treatment of benign prostatic hyperplasia in 1992 and 2002, respectiv...
In recent decades, there has been increased interest in the possible adverse neurological effects of 5α-reductase inhibitors (5-ARIs), which have been used mainly for benign prostatic hyperplasia and ...
To investigate the association of 5-ARI use with all-cause dementia, Alzheimer disease, vascular dementia, depression, and suicide....
This Swedish register-based cohort study included 2 236 876 men aged 50 to 90 years between July 1, 2005, and December 31, 2018. Statistical analyses were performed from September 15, 2021, to May 25,...
A diagnosis of all-cause dementia, Alzheimer disease, vascular dementia, depression, or completed suicide....
A recorded prescription in the Swedish national prescription register of finasteride or dutasteride and duration of use....
Of 2 236 876 men (median age at the start of follow-up, 55 years [IQR, 50-65 years] and at treatment initiation, 73 years [IQR, 66-80 years]), 70 645 (3.2%) started finasteride treatment, and 8774 (0....
This cohort study found that, while men receiving 5-ARI treatment showed a higher risk for dementia in the initial periods after starting treatment, the decreasing magnitude of the association over ti...
Parkinson's disease (PD) is characterized by motor symptoms due to loss of brain dopamine and non-motor symptoms, including gastrointestinal disorders. Although there is no cure for PD, symptomatic tr...
The ability of 5α-reductase inhibitors (5ARI) to reduce the risk of new onset bladder cancer (BC) has been studied with variable results. Our objective was to conduct a retrospective cohort population...
We used routinely collected health care data from Ontario, Canada. Men ≥66 years of age with a prescription for a 5ARI were matched to non-5ARI users. Matching was done using a propensity score of sel...
We identified 93,197 men who initiated 5ARI therapy (52% dutasteride, and 48% finasteride) between 2003 and 2013 and matched them 1:1 to men who did not start a 5ARI. The median at-risk period for the...
In a large cohort of men, the use of a 5ARI was associated with a significantly decreased the risk of BC diagnosis after more than 2 years of continuous therapy....
Concerns exist regarding the effects of 5-alpha reductase inhibitors (5-ARIs) on multipa-rametric magnetic resonance imaging (mpMRI) and clinically significant prostate cancer (csPCa) detection. Our o...
The antiandrogenic effect of the 5α-reductase inhibitor (5-ARI) has been investigated for its role in preventing male-predominant cancers. Although 5-ARI has been widely associated with prostate cance...
To assess the association between 5-ARI prescription prior to BC diagnosis and reduced risk of BC progression....
This cohort study analyzed patient claims data from the Korean National Health Insurance Service database. The nationwide cohort included all male patients with BC diagnosis in this database from Janu...
Newly dispensed prescriptions of 5-ARIs at least 12 months prior to cohort entry (BC diagnosis), with a minimum of 2 prescriptions filled....
The primary outcomes were the risks of bladder instillation and radical cystectomy, and the secondary outcome was all-cause mortality. To compare the risk of outcomes, the hazard ratio (HR) was estima...
The study cohort initially included 22 845 males with BC. After propensity score matching, 5300 patients each were assigned to the α-blocker only group (mean [SD] age, 68.3 [8.8] years) and 5-ARI plus...
Results of this study suggest an association between prediagnostic prescription of 5-ARI and reduced risk of BC progression....