Titre : Antigène CD274

Antigène CD274 : Questions médicales fréquentes

Termes MeSH sélectionnés :

ErbB Receptors
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"datePublished": "2025-05-15", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Antigène CD274", "description": "Comment diagnostiquer une expression anormale de CD274 ?\nQuels tests sanguins sont utilisés pour CD274 ?\nCD274 est-il associé à des biomarqueurs spécifiques ?\nQuels types de cancers montrent une surexpression de CD274 ?\nComment évaluer l'impact de CD274 sur le système immunitaire ?", "url": "https://questionsmedicales.fr/mesh/D060890?mesh_terms=ErbB+Receptors&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Antigène CD274", "description": "Quels symptômes sont liés à une surexpression de CD274 ?\nCD274 influence-t-il les symptômes des maladies auto-immunes ?\nY a-t-il des symptômes spécifiques au cancer liés à CD274 ?\nComment CD274 affecte-t-il la réponse aux infections ?\nLes symptômes de CD274 sont-ils visibles cliniquement ?", "url": 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"https://questionsmedicales.fr/mesh/D060890?mesh_terms=ErbB+Receptors&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Antigène CD274", "description": "Quelles complications sont liées à une surexpression de CD274 ?\nCD274 peut-il aggraver des maladies existantes ?\nY a-t-il des risques de résistance aux traitements avec CD274 ?\nComment CD274 influence-t-il la survie des patients ?\nLes complications de CD274 sont-elles réversibles ?", "url": "https://questionsmedicales.fr/mesh/D060890?mesh_terms=ErbB+Receptors&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Antigène CD274", "description": "Quels facteurs augmentent le risque d'expression de CD274 ?\nLe tabagisme influence-t-il CD274 ?\nY a-t-il un lien entre l'obésité et CD274 ?\nLes infections virales affectent-elles CD274 ?\nLe stress chronique influence-t-il CD274 ?", "url": "https://questionsmedicales.fr/mesh/D060890?mesh_terms=ErbB+Receptors&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une expression anormale de CD274 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests immunohistochimiques peuvent être utilisés pour détecter CD274 dans les tissus." } }, { "@type": "Question", "name": "Quels tests sanguins sont utilisés pour CD274 ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des dosages de cytokines et des tests de surface cellulaire peuvent évaluer CD274." } }, { "@type": "Question", "name": "CD274 est-il associé à des biomarqueurs spécifiques ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, CD274 est souvent associé à des biomarqueurs de cancer comme PD-1." } }, { "@type": "Question", "name": "Quels types de cancers montrent une surexpression de CD274 ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Les cancers du poumon, du sein et de la vessie montrent souvent une surexpression de CD274." } }, { "@type": "Question", "name": "Comment évaluer l'impact de CD274 sur le système immunitaire ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des études fonctionnelles sur les lymphocytes T peuvent évaluer l'impact de CD274." } }, { "@type": "Question", "name": "Quels symptômes sont liés à une surexpression de CD274 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Une surexpression de CD274 peut entraîner une immunosuppression et des infections fréquentes." } }, { "@type": "Question", "name": "CD274 influence-t-il les symptômes des maladies auto-immunes ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, CD274 peut exacerber les symptômes des maladies auto-immunes en inhibant les cellules T." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques au cancer liés à CD274 ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent inclure la fatigue, la perte de poids et des douleurs localisées." } }, { "@type": "Question", "name": "Comment CD274 affecte-t-il la réponse aux infections ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Une expression élevée de CD274 peut réduire l'efficacité de la réponse immunitaire aux infections." } }, { "@type": "Question", "name": "Les symptômes de CD274 sont-ils visibles cliniquement ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Non, CD274 n'a pas de symptômes visibles, mais son impact est observé par des tests." } }, { "@type": "Question", "name": "Peut-on prévenir l'expression de CD274 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de méthode spécifique pour prévenir l'expression de CD274." } }, { "@type": "Question", "name": "Comment un mode de vie sain influence-t-il CD274 ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Un mode de vie sain peut renforcer le système immunitaire, potentiellement régulant CD274." } }, { "@type": "Question", "name": "Y a-t-il des vaccins ciblant CD274 ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de vaccins spécifiquement ciblant CD274." } }, { "@type": "Question", "name": "La détection précoce des cancers aide-t-elle à gérer CD274 ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la détection précoce peut permettre une intervention rapide sur l'expression de CD274." } }, { "@type": "Question", "name": "Les habitudes alimentaires influencent-elles CD274 ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Certaines études suggèrent que l'alimentation peut moduler l'expression de CD274." } }, { "@type": "Question", "name": "Quels traitements ciblent CD274 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les inhibiteurs de PD-1 et PD-L1, comme le pembrolizumab, ciblent CD274." } }, { "@type": "Question", "name": "Comment les thérapies immunologiques agissent-elles sur CD274 ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Elles bloquent l'interaction entre CD274 et PD-1, stimulant ainsi la réponse immunitaire." } }, { "@type": "Question", "name": "CD274 peut-il être une cible pour la thérapie génique ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des recherches explorent la thérapie génique pour moduler l'expression de CD274." } }, { "@type": "Question", "name": "Quels effets secondaires sont associés aux traitements ciblant CD274 ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Les effets secondaires peuvent inclure des réactions auto-immunes et des inflammations." } }, { "@type": "Question", "name": "Les traitements de CD274 sont-ils efficaces pour tous les cancers ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Non, l'efficacité varie selon le type de cancer et le profil immunitaire du patient." } }, { "@type": "Question", "name": "Quelles complications sont liées à une surexpression de CD274 ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent une immunosuppression accrue et une progression tumorale." } }, { "@type": "Question", "name": "CD274 peut-il aggraver des maladies existantes ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, CD274 peut aggraver des maladies auto-immunes et des infections chroniques." } }, { "@type": "Question", "name": "Y a-t-il des risques de résistance aux traitements avec CD274 ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la surexpression de CD274 peut entraîner une résistance aux thérapies immunologiques." } }, { "@type": "Question", "name": "Comment CD274 influence-t-il la survie des patients ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Une expression élevée de CD274 est souvent associée à un pronostic défavorable dans le cancer." } }, { "@type": "Question", "name": "Les complications de CD274 sont-elles réversibles ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque d'expression de CD274 ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents de cancer, des infections chroniques et l'âge." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il CD274 ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut augmenter l'expression de CD274, surtout dans le cancer du poumon." } }, { "@type": "Question", "name": "Y a-t-il un lien entre l'obésité et CD274 ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Des études montrent que l'obésité peut être associée à une expression accrue de CD274." } }, { "@type": "Question", "name": "Les infections virales affectent-elles CD274 ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines infections virales peuvent induire l'expression de CD274 dans les cellules immunitaires." } }, { "@type": "Question", "name": "Le stress chronique influence-t-il CD274 ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Le stress chronique peut moduler l'expression de CD274, affectant la réponse immunitaire." } } ] } ] }

Sources (10000 au total)

Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) patients at advanced stages receive immunotherapy or treatment with tyrosine kinase inhibitors (TKIs) such as Sorafenib (Sora) or Lenvatinib in frontline as well as Rego... In this study, we addressed the impact of the receptor tyrosine kinase Axl binding to its ligand Gas6 in acquiring refractoriness to TKIs. The initial responses of Axl-positive and Axl-negative cell l... We show that HCC cells exhibiting a mesenchymal-like phenotype were less sensitive to drug treatment, linking TKI resistance to changes in epithelial plasticity. Gas6/Axl expression and activation wer... Together, these data suggest that the inhibition of ErbBs is synthetic lethal with Rego in Axl-expressing HCC cells, showing a novel vulnerability of HCC....

The miR-429 suppresses proliferation and migration in glioblastoma cells and induces cell-cycle arrest and apoptosis via modulating several target genes of ERBB signaling pathway.

Glioblastoma multiforme (GBM) is an aggressive and lethal brain cancer, which is incurable with standard cancer treatments. miRNAs have great potential to be used for gene therapy due to their ability... Here, miR-429 was overexpressed using lentiviral vectors in U-251 and U-87 GBM cells and it was observed that the expression level of several oncogenes of the ERBB pathway, EGFR, PIK3CA, PIK3CB, KRAS,... Altogether, miR-429 seems to be an efficient suppressor of the ERBB genetic signaling pathway and a potential therapeutic for GBM....

Mechanisms and therapeutic targets of ErbB family receptors in hepatocellular carcinoma: a narrative review.

Hepatocellular carcinoma (HCC) is a highly heterogeneous and aggressive tumor. In recent years, the incidence of HCC has been increasing worldwide. Despite notable advancements in treatment methodolog... We performed a comprehensive, narrative review of the latest literature to define the current progress of ErbB family receptors in HCC in both the pre-clinical and clinical arenas.... The ErbB family belongs to the tyrosine kinase (TK) receptor family that comprises four members. These members are closely associated with proliferation, cell cycle regulation, and migration during HC... Through in-depth research and the application of ErbB-targeted therapy, broader avenues will be opened for the treatment of HCC and other tumors, leading to more personalized and precise treatment app...

A phase I trial of the pan-ERBB inhibitor neratinib combined with the MEK inhibitor trametinib in patients with advanced cancer with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation.

Aberrant alterations of ERBB receptor tyrosine kinases lead to tumorigenesis. Single agent therapy targeting EGFR or HER2 has shown clinical successes, but drug resistance often develops due to aberra... Patients with actionable somatic mutations or amplifications in ERBB genes or actionable KRAS mutations were enrolled to receive neratinib and trametinib in this phase I dose escalation trial. The pri... Twenty patients were enrolled with a median age of 50.5 years and a median of 3 lines of prior therapy. Grade 3 treatment-related toxicities included: diarrhea (25%), vomiting (10%), nausea (5%), fati... Neratinib and trametinib combination was toxic and had limited clinical efficacy. This may be due to suboptimal drug dosing given drug-drug interactions.... NCT03065387....

Afatinib in combination with GEMOX chemotherapy as the adjuvant treatment in patients with ErbB pathway mutated, resectable gallbladder cancer: study protocol for a ctDNA-based, multicentre, open-label, randomised, controlled, phase II trial.

Gallbladder cancer (GBC) is an aggressive type of digestive system cancer with a dismal outcome. Given the lack of effective treatment options, the disease rapidly reoccurs and 5-year survival rate is... We conduct a multicentre and randomised study on afatinib combined with gemcitabine and oxaliplatin (GEMOX) in patients with ErbB pathway mutated GBC. Clinical and biological evaluation involving ErbB... The study was approved by the medical-ethical review committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and Renji Hospital Affiliated to Shanghai Jiao Tong Uni... NCT04183712....

Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β

Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with ...