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"name": "Diagnostic",
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"description": "Comment diagnostiquer une dysfonction du PRC1 ?\nQuels tests sont utilisés pour évaluer le PRC1 ?\nLe diagnostic nécessite-t-il une biopsie ?\nQuels marqueurs sont associés au PRC1 ?\nLe diagnostic est-il basé sur des symptômes cliniques ?",
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"description": "Quels symptômes indiquent une anomalie du PRC1 ?\nLe PRC1 est-il lié à des cancers spécifiques ?\nLes troubles neurologiques sont-ils liés au PRC1 ?\nLe PRC1 affecte-t-il le métabolisme ?\nY a-t-il des symptômes généraux associés au PRC1 ?",
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"description": "Peut-on prévenir les anomalies liées au PRC1 ?\nY a-t-il des tests de dépistage pour le PRC1 ?\nLes antécédents familiaux influencent-ils le risque ?\nDes conseils génétiques sont-ils disponibles ?\nL'alimentation joue-t-elle un rôle dans la prévention ?",
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"description": "Quels traitements ciblent le PRC1 ?\nLa chimiothérapie est-elle efficace contre les anomalies du PRC1 ?\nDes traitements expérimentaux existent-ils pour le PRC1 ?\nLe PRC1 peut-il être ciblé par des médicaments spécifiques ?\nLes thérapies combinées sont-elles efficaces pour le PRC1 ?",
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"description": "Quelles complications peuvent survenir avec le PRC1 ?\nLe PRC1 est-il lié à des maladies auto-immunes ?\nLes complications sont-elles réversibles ?\nLe PRC1 affecte-t-il la qualité de vie ?\nY a-t-il des complications neurologiques associées ?",
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"name": "Facteurs de risque",
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"description": "Quels sont les facteurs de risque pour le PRC1 ?\nL'âge est-il un facteur de risque pour le PRC1 ?\nLes facteurs environnementaux influencent-ils le PRC1 ?\nLe sexe joue-t-il un rôle dans le risque de PRC1 ?\nLe mode de vie influence-t-il le risque de PRC1 ?",
"url": "https://questionsmedicales.fr/mesh/D063150?mesh_terms=Ventricular+Function,+Left&page=2#section-facteurs de risque"
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction du PRC1 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur des analyses génétiques et des études d'expression génique."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer le PRC1 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de séquençage et des analyses de chromatine sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Le diagnostic nécessite-t-il une biopsie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une biopsie peut être nécessaire pour analyser les tissus affectés par le PRC1."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont associés au PRC1 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs épigénétiques comme les modifications des histones sont souvent analysés."
}
},
{
"@type": "Question",
"name": "Le diagnostic est-il basé sur des symptômes cliniques ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes cliniques peuvent orienter le diagnostic, mais des tests spécifiques sont nécessaires."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une anomalie du PRC1 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies de développement et des troubles de la différenciation cellulaire peuvent survenir."
}
},
{
"@type": "Question",
"name": "Le PRC1 est-il lié à des cancers spécifiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations dans le PRC1 sont associées à divers types de cancers, notamment le cancer du sein."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques sont-ils liés au PRC1 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent un lien entre le PRC1 et des troubles neurologiques, mais les recherches sont en cours."
}
},
{
"@type": "Question",
"name": "Le PRC1 affecte-t-il le métabolisme ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches indiquent que le PRC1 peut influencer le métabolisme cellulaire et énergétique."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes généraux associés au PRC1 ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme la fatigue et des anomalies de croissance peuvent être observés."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les anomalies liées au PRC1 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais un mode de vie sain peut réduire certains risques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour le PRC1 ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de tests de dépistage standardisés pour les anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le risque ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers peuvent augmenter le risque d'anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Des conseils génétiques sont-ils disponibles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des conseils génétiques peuvent aider à évaluer le risque et à discuter des options de prévention."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans la prévention ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut contribuer à la santé cellulaire, mais ne prévient pas spécifiquement les anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent le PRC1 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs de la méthylation des histones et des thérapies géniques sont explorés."
}
},
{
"@type": "Question",
"name": "La chimiothérapie est-elle efficace contre les anomalies du PRC1 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chimiothérapie peut être utilisée, mais son efficacité dépend du type de cancer associé."
}
},
{
"@type": "Question",
"name": "Des traitements expérimentaux existent-ils pour le PRC1 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des traitements expérimentaux sont en cours d'évaluation dans des essais cliniques."
}
},
{
"@type": "Question",
"name": "Le PRC1 peut-il être ciblé par des médicaments spécifiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches sont en cours pour développer des médicaments ciblant spécifiquement le PRC1."
}
},
{
"@type": "Question",
"name": "Les thérapies combinées sont-elles efficaces pour le PRC1 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les thérapies combinées peuvent améliorer l'efficacité des traitements contre les cancers liés au PRC1."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le PRC1 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers avancés et des troubles de développement sévères."
}
},
{
"@type": "Question",
"name": "Le PRC1 est-il lié à des maladies auto-immunes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études suggèrent un lien potentiel entre le PRC1 et certaines maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles."
}
},
{
"@type": "Question",
"name": "Le PRC1 affecte-t-il la qualité de vie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les anomalies du PRC1 peuvent significativement affecter la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications neurologiques associées ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies du PRC1 peuvent entraîner des complications neurologiques, comme des troubles cognitifs."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour le PRC1 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des mutations génétiques, des antécédents familiaux et des expositions environnementales."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le PRC1 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains types de cancers liés au PRC1 sont plus fréquents chez les personnes âgées."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils le PRC1 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des expositions à des agents cancérigènes peuvent augmenter le risque d'anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque de PRC1 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains cancers liés au PRC1 montrent des différences de prévalence entre les sexes."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque de PRC1 ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie malsain, comme le tabagisme, peut augmenter le risque d'anomalies du PRC1."
}
}
]
}
]
}
Arterial structural and functional remodeling is recognized as a key determinant of incident heart failure, although the contribution of arterial properties on left ventricular (LV) remodeling is not ...
The study cohort consisted of 539 participants without overt cardiac disease who underwent extensive cardiovascular examination. Aortic root diameter was measured by two-dimensional echocardiography a...
Aortic root diameter and ePWV were correlated with LV mass index and LVGLS, while only ePWV was related to E / e' ratio. In multivariable analysis, aortic root diameter and ePWV were significantly rel...
Aortic root size and ePWV were independently associated with unfavorable LV remodeling in individuals free of cardiac disease, which might provide useful information into the pathogenesis-linking arte...
Cardiac sarcoidosis (CS) is an important cause of cardiomyopathy. The trajectory of left ventricular ejection fraction (LVEF) in patients with CS undergoing treatment remains unclear. Patients with CS...
Peripartum cardiomyopathy (PPCM) is a rare type of cardiomyopathy that manifests as acute heart failure associated with pregnancy. Delays in early identification result in poor recovery of left ventri...
All baseline and clinical parameters were prospectively collected from a cohort of patients with PPCM admitted to Dr. Hasan Sadikin General Hospital in Bandung, Indonesia between January 2014 and Dece...
This prospective cohort study included 113 patients with PPCM (84 recovered and 29 non-recovered patients). Significant mitral regurgitation (MR), left ventricular ejection fraction (LVEF) <30%, left ...
PPCM recovery score is a convenient scoring system based on clinical and echocardiography assessment that may assist in distinguishing which patients are more likely to develop poor LV function recove...
Iron deficiency anemia (IDA) is a common health problem worldwide. The objective of this study was to noninvasively and quantitatively evaluate early changes in left ventricular systolic function in p...
Sixty-two patients with IDA were selected and divided into two groups based on hemoglobin (Hb) concentration: Group B with Hb > 9 g/dL and group C with 6 g/dL < Hb < 9 g/dL. Thirty-three healthy indiv...
Compared to group A, GWI and GCW were reduced in group B (both P < 0.01). Compared with groups B and A, GLS, GWI, GCW and GWE, and E/A were all diminished, and GWW, LVEDV, LVESV, and E/mean e' were al...
LV-PSL allows noninvasive quantitative assessment of early impaired LV systolic function in IDA patients with preserved LV ejection fraction, and GWI has high sensitivity and specificity compared with...
Left atrial (LA) strain has emerged as a useful parameter for the assessment of left ventricular (LV) diastolic function and the estimation of LV filling pressures. Some have advocated using LA strain...
Spirometric abnormalities have been related to incident heart failure in general population, who generally have preserved left ventricular ejection fraction (LVEF). We aimed to investigate the associa...
Subjects presenting with exertional dyspnoea and received spirometry and echocardiography were eligible for this study. Forced vital capacity (FVC) and forced expiratory volume in the first second (FE...
Among a total of 8669 participants (65.8 ± 16.3 years, 56% men), 3739 (43.1%), 829 (9.6%), 3050 (35.2%) and 1051 (12.1%) had normal, obstructive, restrictive and mixed spirometry pattern, respectively...
The restrictive spirometry pattern or the declined FVC was associated with left ventricular diastolic dysfunction, which aggravated the long-term mortality in the ambulatory dyspnoeic subjects....
Coronary microvascular dysfunction (CMD) has been proposed as an important pathophysiological mechanism in Takotsubo syndrome (TTS). Our aims were (i) to evaluate and compare levels of CMD in patients...
We conducted a prospective study of 27 female TTS patients and an equally sized, age- and gender-matched, cohort of INOCA patients. Coronary microvascular function was quantified invasively using the ...
Coronary microvascular dysfunction is common in patients with TTS and more frequent than in patients with INOCA. CMD in TTS is more severe in the apical compared with the midventricular phenotype of t...
The relationship between left ventricle (LV), extracellular matrix remodeling and fibrosis-linked amphiregulin (ARG) in cirrhotic cardiomyopathy (CCM) is unknown. The aim of the study was to investiga...
Significant left-to-right shunt across a ventricular septal defect (VSD) may lead to left ventricle (LV) volume overload and dilation. The acute loss of LV preload after repair of VSD may contribute t...
To explore left ventricular structural/functional abnormalities in preeclampsia patients by using multimodal echocardiography and to analyze the cardiac impact in preeclampsia subtypes....
A total of 103 individuals, including 64 preeclampsia patients and 39 healthy pregnant women were recruited for this study from 2019 to 2021. There were 34 patients with preeclampsia with severe featu...
EO-SPE patients showed decreased left ventricular ejection fractions, peak longitudinal systolic strain at apical four-chambers, peak circumferential, and radial systolic strain at the apical and mitr...
EO-SPE patients were characterized by left ventricular injury and systolic function reduced. LO-SPE patients were characterized by left ventricular hypertrophy and reduced diastolic function. Multimod...