Titre : Protéines de maintenance des minichromosomes

Protéines de maintenance des minichromosomes : Questions médicales fréquentes

Termes MeSH sélectionnés :

Meropenem
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maintenance des minichromosomes", "description": "Comment diagnostiquer une anomalie des protéines MCM ?\nQuels tests sont utilisés pour évaluer les MCM ?\nLes niveaux de MCM peuvent-ils être mesurés ?\nQuels marqueurs sont associés aux MCM ?\nLes MCM sont-elles liées à des cancers spécifiques ?", "url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Meropenem&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Protéines de maintenance des minichromosomes", "description": "Quels symptômes indiquent une dysfonction des MCM ?\nLes symptômes sont-ils spécifiques aux MCM ?\nComment les MCM affectent-elles la santé cellulaire ?\nLes MCM sont-elles liées à des symptômes neurologiques ?\nPeut-on observer des symptômes précoces de dysfonction MCM ?", "url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Meropenem&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Protéines de maintenance des minichromosomes", "description": "Peut-on prévenir les anomalies des MCM ?\nY a-t-il des tests de dépistage pour les MCM ?\nL'alimentation influence-t-elle les MCM ?\nLe stress affecte-t-il les MCM ?\nLes exercices physiques aident-ils les MCM ?", "url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Meropenem&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Protéines de maintenance des minichromosomes", "description": "Quels traitements ciblent les MCM ?\nLes thérapies géniques peuvent-elles aider ?\nY a-t-il des médicaments pour les MCM ?\nComment la chimiothérapie affecte-t-elle les MCM ?\nLes traitements sont-ils personnalisés pour les MCM ?", "url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Meropenem&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Protéines de maintenance des minichromosomes", "description": "Quelles complications peuvent survenir avec des anomalies MCM ?\nLes anomalies MCM sont-elles héréditaires ?\nComment les MCM affectent-elles le vieillissement ?\nLes MCM sont-elles liées à des maladies auto-immunes ?\nLes anomalies MCM peuvent-elles causer des troubles neurologiques ?", "url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Meropenem&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Protéines de maintenance des minichromosomes", "description": "Quels facteurs augmentent le risque d'anomalies MCM ?\nL'exposition à des toxines influence-t-elle les MCM ?\nLe tabagisme affecte-t-il les MCM ?\nLe vieillissement est-il un facteur de risque pour les MCM ?\nLes antécédents familiaux influencent-ils les MCM ?", "url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Meropenem&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une anomalie des protéines MCM ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses de protéines peuvent identifier des anomalies." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer les MCM ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "L'immunobuvardage et la PCR sont couramment utilisés pour évaluer les MCM." } }, { "@type": "Question", "name": "Les niveaux de MCM peuvent-ils être mesurés ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les niveaux de MCM peuvent être mesurés par des techniques de biologie moléculaire." } }, { "@type": "Question", "name": "Quels marqueurs sont associés aux MCM ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Les marqueurs de prolifération cellulaire, comme Ki-67, sont souvent associés aux MCM." } }, { "@type": "Question", "name": "Les MCM sont-elles liées à des cancers spécifiques ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des niveaux élevés de MCM sont souvent associés à divers types de cancers." } }, { "@type": "Question", "name": "Quels symptômes indiquent une dysfonction des MCM ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des anomalies dans la réplication de l'ADN peuvent entraîner des symptômes variés." } }, { "@type": "Question", "name": "Les symptômes sont-ils spécifiques aux MCM ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Non, les symptômes peuvent varier selon le type de maladie associée aux MCM." } }, { "@type": "Question", "name": "Comment les MCM affectent-elles la santé cellulaire ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Une mauvaise fonction des MCM peut entraîner des erreurs dans la réplication de l'ADN." } }, { "@type": "Question", "name": "Les MCM sont-elles liées à des symptômes neurologiques ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Certaines études suggèrent un lien entre les MCM et des troubles neurologiques." } }, { "@type": "Question", "name": "Peut-on observer des symptômes précoces de dysfonction MCM ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des signes précoces peuvent inclure des anomalies de croissance cellulaire." } }, { "@type": "Question", "name": "Peut-on prévenir les anomalies des MCM ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une bonne hygiène de vie et un suivi médical régulier peuvent aider à prévenir." } }, { "@type": "Question", "name": "Y a-t-il des tests de dépistage pour les MCM ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques peuvent être proposés pour les personnes à risque élevé." } }, { "@type": "Question", "name": "L'alimentation influence-t-elle les MCM ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée peut soutenir la santé cellulaire et la fonction des MCM." } }, { "@type": "Question", "name": "Le stress affecte-t-il les MCM ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Le stress chronique peut perturber la fonction cellulaire, y compris celle des MCM." } }, { "@type": "Question", "name": "Les exercices physiques aident-ils les MCM ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la fonction des MCM." } }, { "@type": "Question", "name": "Quels traitements ciblent les MCM ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des inhibiteurs spécifiques de MCM sont en cours de développement pour le cancer." } }, { "@type": "Question", "name": "Les thérapies géniques peuvent-elles aider ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la thérapie génique pourrait corriger les anomalies des MCM dans certains cas." } }, { "@type": "Question", "name": "Y a-t-il des médicaments pour les MCM ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments ciblant la voie de réplication de l'ADN sont en développement." } }, { "@type": "Question", "name": "Comment la chimiothérapie affecte-t-elle les MCM ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "La chimiothérapie peut perturber la fonction des MCM, affectant la réplication cellulaire." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés pour les MCM ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des profils de MCM des patients." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec des anomalies MCM ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent des cancers, des troubles de croissance et des maladies génétiques." } }, { "@type": "Question", "name": "Les anomalies MCM sont-elles héréditaires ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines anomalies peuvent être héréditaires, augmentant le risque de maladies." } }, { "@type": "Question", "name": "Comment les MCM affectent-elles le vieillissement ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Des dysfonctionnements des MCM peuvent accélérer le vieillissement cellulaire et tissulaire." } }, { "@type": "Question", "name": "Les MCM sont-elles liées à des maladies auto-immunes ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Des recherches suggèrent un lien potentiel entre les MCM et certaines maladies auto-immunes." } }, { "@type": "Question", "name": "Les anomalies MCM peuvent-elles causer des troubles neurologiques ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans les MCM peuvent être associées à des troubles neurologiques." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque d'anomalies MCM ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent augmenter le risque." } }, { "@type": "Question", "name": "L'exposition à des toxines influence-t-elle les MCM ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certaines toxines peut perturber la fonction des MCM." } }, { "@type": "Question", "name": "Le tabagisme affecte-t-il les MCM ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Le tabagisme est un facteur de risque connu pour des anomalies dans la fonction des MCM." } }, { "@type": "Question", "name": "Le vieillissement est-il un facteur de risque pour les MCM ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement peut affecter la fonction des MCM et augmenter le risque de maladies." } }, { "@type": "Question", "name": "Les antécédents familiaux influencent-ils les MCM ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de maladies liées aux MCM peuvent augmenter le risque." } } ] } ] }

Sources (484 au total)

Chemical stability and physical compatibility of meropenem in admixtures for continuous and extended intravenous infusions.

Prolonged intravenous infusion of beta-lactams increase the clinical cure rate compared to conventional administration in critical or septic patients. This study aimed to determine chemical stability ... Admixtures in study were: (i) meropenem 6g in 0.9% sodium chloride (NS) in infusor of 2mL/h 50mL or 10mL/h 240mL; (ii) meropenem 1 or 2g in NS in infusion bag of 250mL. Temperatures of study were: (i)... Chemical stability and physical compatibility of meropenem in admixtures in infusors were reduced at high meropenem concentration and high temperature. Admixtures in infusion bag show chemical stabili... Administration of meropenem 6g in infusion of 24h in 240mL of 0.9% NaCl in infusor of 10mL/h could be possible if the admixture is infused at 4.5°C. Extended infusion of meropenem 1 or 2g in 0.9% NaCl...

Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling.

Meropenem is a carbapenem antibiotic often used in pediatric intensive care units due to its broad spectrum of activity. Therapeutic drug monitoring (TDM) is a useful tool to increase the effectivenes... VAMS technology using 10 µL of WB was evaluated and compared with EDTA-plasma sampling. High-performance liquid chromatography with UV detection was applied to quantify meropenem in VAMS and plasma sa... It was found that no consistent factor could be determined to calculate meropenem plasma concentrations from the WB, indicating that VAMS was not reliable in the TDM of meropenem. Therefore, to reduce... A simple, reliable, and low-cost method was established using high-performance liquid chromatography-UV to determine the concentration of meropenem in 50 µL of plasma. VAMS using WB does not seem to b...

Investigation of in vitro efficacy of quercetin-meropenem combination in carbapenemase-producing Klebsiella pneumoniae isolates.

In recent years, the rapid spread of carbapenem-resistant K. pneumoniae, their higher mortality rates, and limited treatment alternatives cause difficulties in the treatment of these infections. New t... Thirty Carbapenem-resistant K.pneumoniae strains in the culture collection of our laboratory were included in our study. Carbapenemase genes were determined using the Xpert® Carba-R (Cepheid, USA). Sy... Twenty (66.6%) strains had OXA-48, 6 (20%) NDM, 1 (3.3%) KPC, 1 (3.3%) OXA-48+NDM genes, and 2 strains (6.6%) gene could not be detected. In the Quercetin and Meropenem combination study, synergy was ... Although the combination of quercetin and meropenem has a high synergistic effect in carbapenem-resistant K. pneumoniae isolates, it seems that the carbapenemase species affects this situation. howeve...

Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis.

Creatinine clearance (CCr) and pharmacokinetic parameters are markedly affected by pathophysiological changes in patients with sepsis. However, only a few reports have assessed renal function in patie... Patients with sepsis who received intravenous meropenem at the Showa University Hospital were enrolled in this prospective observational study. The PPK model was constructed using blood samples and cl... One hundred samples were collected from 31 patients. The final PPK model incorporating the measured CCr as a covariate in CL displayed the best fit. The recommended dosing regimen to achieve a PTA of ... This model precisely predicted meropenem concentrations in patients with sepsis by accurately evaluating renal function using the measured CCr. Extended dosing was demonstrated to be necessary to achi...

Prediction of Tissue Exposures of Meropenem, Colistin, and Sulbactam in Pediatrics Using Physiologically Based Pharmacokinetic Modeling.

The combination of polymyxins, meropenem, and sulbactam demonstrated efficacy against multi-drug-resistant bacillus Acinetobacter baumannii. These three antibiotics are commonly used against major blo... The objective of this study was to predict drug disposition and extrapolate the efficacy in these tissues using a physiologically based pharmacokinetic modeling approach that linked drug exposures to ... An adult physiologically based pharmacokinetic model was developed for meropenem, colistin, and sulbactam and scaled to pediatrics accounting for both renal and non-renal clearances. The model reliabi... The modeled plasma drug exposures in adults and pediatric patients were consistent with reported literature data. The mean fold errors for meropenem, colistin, and sulbactam were in the range of 0.710... The physiologically based pharmacokinetic modeling supports pediatric dosing regimens of meropenem/colistin/sulbactam in a co-administration setting against infections in the blood, lung, skin, and he...