questionsmedicales.fr
Phénomènes génétiques
Régulation de l'expression des gènes
Épigenèse génétique
Extinction de l'expression des gènes
Systèmes CRISPR-Cas
Systèmes CRISPR-Cas : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Séquençage génétique
Bioinformatique
Échantillons cliniques
Analyse génétique
Gènes Cas
Séquences répétées
Efficacité
Modification génétique
Symptômes
5
Anomalies cellulaires
Modification génétique
Effets secondaires
Mutations off-target
Maladies génétiques
Modifications non ciblées
Réponse immunitaire
Inflammation
Surveillance
Examens cliniques
Prévention
5
Prévention
Mutations héréditaires
Embryons
Gènes pathogènes
Risques
Modifications non intentionnelles
Protocoles de sécurité
Évaluations éthiques
Infections
Virus pathogènes
Traitements
5
Maladies génétiques
Cancers
Drépanocytose
Fibrose kystique
Injection
Administration de médicaments
Essais cliniques
Résultats prometteurs
Thérapie génique
Mutations
Complications
5
Complications
Réponses immunitaires
Gestion des complications
Suivi médical
Cancers
Modifications non ciblées
Tests génétiques
Examens de santé
Effets à long terme
Études approfondies
Facteurs de risque
5
Facteurs de risque
Antécédents médicaux
Personnes âgées
Fragilité cellulaire
Maladies auto-immunes
Réactions indésirables
Antécédents familiaux
Maladies génétiques
Facteurs environnementaux
Efficacité
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"@type": "Question",
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"@type": "Question",
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{
"@type": "Question",
"name": "CRISPR peut-il causer des maladies ?",
"position": 8,
"acceptedAnswer": {
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"text": "Des modifications non ciblées peuvent potentiellement induire des maladies génétiques."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une réponse immunitaire à CRISPR ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes incluent inflammation, douleur ou réactions allergiques au site d'injection."
}
},
{
"@type": "Question",
"name": "Comment surveiller les effets de CRISPR ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "La surveillance se fait par des examens cliniques réguliers et des tests génétiques."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il prévenir des maladies génétiques ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "CRISPR a le potentiel de prévenir des maladies en corrigeant des mutations héréditaires."
}
},
{
"@type": "Question",
"name": "Comment CRISPR peut-il être utilisé en prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il peut être utilisé pour modifier des embryons afin d'éliminer des gènes pathogènes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques dans l'utilisation préventive de CRISPR ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des risques incluent des modifications non intentionnelles et des effets à long terme inconnus."
}
},
{
"@type": "Question",
"name": "Quels protocoles de sécurité existent pour CRISPR ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des protocoles incluent des tests rigoureux et des évaluations éthiques avant l'application."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il être utilisé pour prévenir des infections ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches explorent l'utilisation de CRISPR pour cibler des virus et bactéries pathogènes."
}
},
{
"@type": "Question",
"name": "CRISPR est-il utilisé pour traiter des maladies ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, CRISPR est exploré pour traiter des maladies génétiques et certains cancers."
}
},
{
"@type": "Question",
"name": "Quels types de maladies peuvent être ciblés par CRISPR ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "CRISPR cible des maladies comme la drépanocytose, la fibrose kystique et certains cancers."
}
},
{
"@type": "Question",
"name": "Comment CRISPR est-il administré en traitement ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "CRISPR est généralement administré par injection dans les cellules ou tissus ciblés."
}
},
{
"@type": "Question",
"name": "Quels sont les résultats des essais cliniques avec CRISPR ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les essais montrent des résultats prometteurs, mais nécessitent encore des études approfondies."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il être utilisé en thérapie génique ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, CRISPR est une approche innovante en thérapie génique pour corriger des mutations."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec CRISPR ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des réponses immunitaires, des mutations off-target et des infections."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées à CRISPR ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion implique un suivi médical étroit et des traitements symptomatiques appropriés."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il entraîner des cancers ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des modifications non ciblées par CRISPR pourraient théoriquement induire des cancers."
}
},
{
"@type": "Question",
"name": "Quels tests sont nécessaires après un traitement CRISPR ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des examens de santé réguliers sont recommandés après traitement."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets à long terme de CRISPR ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets à long terme sont encore mal compris et nécessitent des études approfondies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour l'utilisation de CRISPR ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents médicaux, des mutations génétiques et des conditions immunitaires."
}
},
{
"@type": "Question",
"name": "Les personnes âgées sont-elles à risque avec CRISPR ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées peuvent avoir un risque accru en raison de la fragilité cellulaire."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes augmentent-elles les risques de CRISPR ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les maladies auto-immunes peuvent augmenter le risque de réactions indésirables."
}
},
{
"@type": "Question",
"name": "Comment les antécédents familiaux influencent-ils l'utilisation de CRISPR ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antécédents familiaux de maladies génétiques peuvent influencer les décisions thérapeutiques."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux affectent-ils CRISPR ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs environnementaux peuvent influencer l'efficacité et la sécurité de CRISPR."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 21/03/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India. Electronic address: vijaisingh15@gmail.com.
Publications dans "Systèmes CRISPR-Cas" :
4 publications dans cette catégorie
Affiliations :
Genomic Sciences Graduate Program, North Carolina State University, Raleigh, NC, United States; Department of Food, Bioprocessing & Nutrition Sciences, North Carolina State University, Raleigh, NC, United States. Electronic address: rbarran@ncsu.edu.
Publications dans "Systèmes CRISPR-Cas" :
3 publications dans cette catégorie
Affiliations :
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Publications dans "Systèmes CRISPR-Cas" :
3 publications dans cette catégorie
Affiliations :
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Publications dans "Systèmes CRISPR-Cas" :
3 publications dans cette catégorie
Affiliations :
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Publications dans "Systèmes CRISPR-Cas" :
3 publications dans cette catégorie
Affiliations :
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Publications dans "Systèmes CRISPR-Cas" :
3 publications dans cette catégorie
Affiliations :
National Center for Biotechnology Information, National Library of Medicine , Bethesda, MD 20894 , USA.
Publications dans "Systèmes CRISPR-Cas" :
3 publications dans cette catégorie
Affiliations :
National Center for Biotechnology Information, National Library of Medicine , Bethesda, MD 20894 , USA.
Publications dans "Systèmes CRISPR-Cas" :
3 publications dans cette catégorie
Affiliations :
Department of Microbiology, Gargi College, University of Delhi, New Delhi, India. Electronic address: indra.mani@gargi.du.ac.in.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular Microbiology, Biological and Chemical Research Centre, Faculty of Biology, University of Warsaw, Warsaw, Poland.
Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan; Advanced Drug Delivery and Regenerative Biomaterials Lab, Stanford University School of Medicine, Stanford University, Palo Alto, CA, United States. Electronic address: mustafeez.babar@fulbrightmail.org.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Advanced Drug Delivery and Regenerative Biomaterials Lab, Stanford University School of Medicine, Stanford University, Palo Alto, CA, United States. Electronic address: jayraja@stanford.edu.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Kavli Institute of Nanoscience, Department of Bionanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, the Netherlands; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands. Electronic address: stanbrouns@gmail.com.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
a Faculty of Biology, Genetics and Experimental Bioinformatics , University of Freiburg , Freiburg , Germany.
f Freiburg Institute for Advanced Studies,University of Freiburg, Freiburg, Germany.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Genomic Sciences Graduate Program, North Carolina State University, Raleigh, NC, United States; Department of Food, Bioprocessing & Nutrition Sciences, North Carolina State University, Raleigh, NC, United States.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Department of Microbiology, Gargi College, University of Delhi, New Delhi, India.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Department of Biosciences and Biomedical Engineering, Indian Institute of Technology, Indore, India.
Publications dans "Systèmes CRISPR-Cas" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi, India.
Publications dans "Systèmes CRISPR-Cas" :
Research on achievement goals is voluminous but focused primarily on intrapersonal regulation. In the present article, we emphasize the integral role that achievement goals also play in the broader pr...
Seriously ill patients whose prioritized healthcare goals are understood by their clinicians are likely better positioned to receive goal-concordant care....
To examine the proportion of seriously ill patients whose prioritized healthcare goal is accurately perceived by their clinician and identify factors associated with accurate perception....
Secondary analysis of a multicenter cluster-randomized trial of outpatients with serious illness and their clinicians. Approximately two weeks after a clinic visit, patients reported their current pri...
Of 252 patients with a prioritized healthcare goal, 60% had their goal accurately perceived by their clinician, 27% were cared for by clinicians who perceived prioritization of the alternative goal, a...
A majority of seriously ill outpatients are cared for by clinicians who accurately perceive their patients' prioritized healthcare goals. However, a substantial portion are not and may be at higher ri...
Across rehabilitation fields, rehabilitees and professionals meet to set rehabilitation goals. Portrayed as an ordinary, yet foundational practice in rehabilitation, participants often find goal-setti...
Studies of goal setting in later life tend to focus on health-related goal setting, are pre-determined by the researcher (i.e., tick box), and/or are focused on a specific geographical area (i.e., one...
Through a cross-sectional, online survey (N = 1,551), this exploratory study examined the qualitative goal content of older adults. Thematic analysis was used to analyze the qualitative data, and biva...
Over 60% of the participants reported setting goals, and participants from the Australia-NZ and Canada-USA regions were more likely to set goals than the UK-Ireland region. The following six overarchi...
This study supports previous research that demonstrates that older adults can and do set personal goals that are wide ranging. These findings support the need for health professionals to consider diff...
This research challenges the idea that teams from more collectivistic cultures tend to perform better. We propose that in contexts in which there are tradeoffs between group goals (i.e., what is best ...
Adult Spinal Deformity (ASD) is a complex pathologic condition with significant impact on quality of life, including pain, loss of function, and fatigue. Achieving realignment goals is crucial for lon...
To develop an expert-informed (including end users) recovery goal menu for adults recovering from critical illness applicable to the community/home setting....
Stage 1 Item generation: iterative development of domains, sub-domains, and goals in consultation with former intensive care patients, family members and expert clinicians. Stage 2 Content validity as...
Virtual consultation meetings facilitated by the research team at King's College London and Guy's and St Thomas' NHS Foundation Trust....
Content validity as assessed by: the Item-Content Validity Index (I-CVI), Scale Level-Content Validity Index/Universal Agreement (S-CVI/UA) score, the Scale Level-Content Validity Index/Average (S-CVI...
Item generation resulted in a goal menu comprising 4 domains, 22 sub-domains and 95 goals assigned as follows: Self-care: 9 sub-domains with 37 goals, Productivity: 7 sub-domains with 13 goals, Leisur...
An expert informed recovery goal menu for former intensive care patients has been developed with excellent content validity. The final goal menu comprises 169 goals within 24 sub-domains grouped under...
This menu will help patients to set goals and increase our understanding of how individuals recover from critical illness....
Goals provide insight into what is important to an individual. We describe the development and application of a mixed methods approach to elicit goals and perceptions about goals in patients with adva...
Patients receiving first-line treatment for advanced lung cancer participated in semi-structured interviews about their goals. Participants self-generated goals, then selected and ranked their three m...
Participants (N = 75, M...
A majority of participant goals focused on meaningful engagement and living well. Goals were largely viewed as attainable and under participants' control. Cancer clinicians may consider how to support...
Patient-centered care reflecting patient preferences and needs is integral to high-quality care. Individualized care is important for psychosocially complex or high-risk patients with multiple chronic...
We sought to clarify facilitators and barriers perceived by primary care physicians in the Veterans Health Administration to delivering patient-centered care for high-risk or complex patients with mul...
We conducted semi-structured telephone interviews from April to July 2020 among physicians across 20 clinical sites. Findings were analyzed with deductive content analysis based on conceptual models o...
Of 23 physicians interviewed, most were female (n = 14/23, 61%), serving in hospital-affiliated outpatient clinics (n = 14/23, 61%). Participants had a mean of 21 (SD = 11.3) years of experience....
Facilitators included the following: effective physician-patient communication to individualize care, prioritize among multiple needs, and elicit goals to improve patient engagement; access to care, e...
Physicians perceived individual physician-patient interactions were the greatest facilitators or barriers to patient-centered care. Efforts to increase primary care patient-centeredness for complex or...
While previous studies have highlighted the role of episodic future thinking in goal pursuit, the underlying cognitive mechanisms remain unexplored. Episodic future thinking may promote goal pursuit b...