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"description": "Comment diagnostiquer une anomalie des kinases Aurora ?\nQuels marqueurs sont associés aux kinases Aurora ?\nLes kinases Aurora sont-elles liées à des cancers spécifiques ?\nQuels tests sont utilisés pour évaluer l'activité des kinases Aurora ?\nPeut-on détecter les kinases Aurora dans le sang ?",
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie des kinases Aurora ?",
"position": 1,
"acceptedAnswer": {
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"text": "Des tests génétiques et des analyses de tissus tumoraux peuvent révéler des anomalies."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont associés aux kinases Aurora ?",
"position": 2,
"acceptedAnswer": {
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"text": "Les niveaux d'expression des kinases Aurora A et B peuvent servir de marqueurs tumoraux."
}
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"@type": "Question",
"name": "Les kinases Aurora sont-elles liées à des cancers spécifiques ?",
"position": 3,
"acceptedAnswer": {
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"text": "Oui, elles sont souvent surexprimées dans des cancers comme le sein et le poumon."
}
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité des kinases Aurora ?",
"position": 4,
"acceptedAnswer": {
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"text": "Des tests de phosphorylation et des analyses de Western blot sont couramment utilisés."
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"@type": "Question",
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}
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"name": "Quels symptômes sont liés à une dysrégulation des kinases Aurora ?",
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"text": "Les symptômes varient selon le cancer, mais peuvent inclure fatigue, douleur et perte de poids."
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{
"@type": "Question",
"name": "Les kinases Aurora affectent-elles la division cellulaire ?",
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"text": "Oui, elles jouent un rôle clé dans la mitose, et leur dysfonction peut entraîner des anomalies cellulaires."
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"@type": "Question",
"name": "Y a-t-il des signes précoces de cancer liés aux kinases Aurora ?",
"position": 8,
"acceptedAnswer": {
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"text": "Des signes précoces peuvent inclure des changements inexpliqués dans le corps, mais sont souvent vagues."
}
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{
"@type": "Question",
"name": "Les kinases Aurora sont-elles impliquées dans des symptômes neurologiques ?",
"position": 9,
"acceptedAnswer": {
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"text": "Certaines études suggèrent un lien entre les kinases Aurora et des troubles neurologiques dans certains cancers."
}
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"@type": "Question",
"name": "Comment les kinases Aurora influencent-elles la croissance tumorale ?",
"position": 10,
"acceptedAnswer": {
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"text": "Elles régulent la mitose, et leur surexpression peut conduire à une croissance tumorale incontrôlée."
}
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{
"@type": "Question",
"name": "Peut-on prévenir les anomalies des kinases Aurora ?",
"position": 11,
"acceptedAnswer": {
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"text": "Il n'existe pas de méthode spécifique, mais un mode de vie sain peut réduire le risque de cancer."
}
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"@type": "Question",
"name": "Les dépistages réguliers aident-ils à détecter les problèmes liés aux kinases Aurora ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, des dépistages réguliers peuvent aider à détecter des cancers associés aux anomalies des kinases."
}
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{
"@type": "Question",
"name": "Y a-t-il des facteurs de mode de vie influençant les kinases Aurora ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et l'exercice peuvent influencer la santé cellulaire et réduire les risques."
}
},
{
"@type": "Question",
"name": "Les antioxydants aident-ils à prévenir les anomalies des kinases Aurora ?",
"position": 14,
"acceptedAnswer": {
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"text": "Des études suggèrent que les antioxydants peuvent réduire le stress oxydatif, mais des recherches sont nécessaires."
}
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{
"@type": "Question",
"name": "Les vaccinations peuvent-elles prévenir les cancers liés aux kinases Aurora ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations, comme celles contre le HPV, peuvent réduire le risque de cancers spécifiques."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent les kinases Aurora ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques des kinases Aurora sont en développement pour traiter divers cancers."
}
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{
"@type": "Question",
"name": "Les inhibiteurs de kinases Aurora sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études montrent qu'ils peuvent réduire la croissance tumorale, mais des recherches sont nécessaires."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires peuvent résulter des traitements ciblant les kinases Aurora ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure nausées, fatigue et troubles hématologiques."
}
},
{
"@type": "Question",
"name": "Les traitements ciblant les kinases Aurora sont-ils combinés avec d'autres thérapies ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils sont souvent combinés avec la chimiothérapie ou la radiothérapie pour améliorer l'efficacité."
}
},
{
"@type": "Question",
"name": "Y a-t-il des essais cliniques sur les kinases Aurora ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, plusieurs essais cliniques évaluent l'efficacité des inhibiteurs de kinases Aurora dans divers cancers."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies des kinases Aurora ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent la progression rapide du cancer et la résistance aux traitements."
}
},
{
"@type": "Question",
"name": "Les anomalies des kinases Aurora augmentent-elles le risque de métastases ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surexpression des kinases Aurora est souvent associée à une augmentation des métastases."
}
},
{
"@type": "Question",
"name": "Comment les anomalies des kinases Aurora affectent-elles le pronostic ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles sont souvent liées à un pronostic défavorable en raison de la croissance tumorale agressive."
}
},
{
"@type": "Question",
"name": "Les complications des traitements ciblant les kinases Aurora sont-elles fréquentes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des complications comme des infections et des troubles sanguins peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les anomalies des kinases Aurora peuvent-elles affecter la réponse immunitaire ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent altérer la réponse immunitaire, rendant le corps moins efficace contre le cancer."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque associés aux anomalies des kinases Aurora ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux de cancer, l'exposition à des agents cancérigènes."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque d'anomalies des kinases Aurora ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque d'anomalies des kinases Aurora augmente généralement avec l'âge."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque pour les kinases Aurora ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme est un facteur de risque connu pour plusieurs types de cancer associés aux kinases."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans les anomalies des kinases Aurora ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en graisses et en sucres peut augmenter le risque de cancer et d'anomalies."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles liées aux anomalies des kinases Aurora ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales, comme le HPV, sont associées à des cancers où les kinases Aurora sont impliquées."
}
}
]
}
]
}
Various assay methods have been developed to study antimicrobial activity based on contamination of surfaces with different amounts of liquid bacterial suspensions. Since surfaces with frequent hand c...
To investigate a surface previously confirmed to display antimicrobial activity even after drying of small volumes of bacterial suspension (Egger antimicrobial surfaces: EAS) under conditions modellin...
EAS, an antimicrobial copper alloy, as well as a negative control were examined to assess interlaboratory test reproducibility....
Significantly fewer bacteria on EAS after touch transfer and some differences in the touch transmission were detected between the two laboratories. However, an identical assessment of effectiveness fo...
Since, in the real world of a hospital, organisms are typically transferred between dry surfaces, further standardization of the touch-transfer method is worthwhile for a better understanding of the e...
Color imaging is a tried and true method for the evaluation of cosmetic and dermatological effects, but it fails to capture all the information in a scene's spectral reflectance. For this reason, ther...
We developed a novel HyperSpectral Imager (HSI) able to take in vivo full-face format images as a next generation instrument for skin color measurement and beyond. Here, we report part of the results ...
We find that the measurements from the HSI provide repeatability and reproducibility as good or better than those of our previous benchmark devices....
From these results, we conclude that not only is the HSI suitable for use in color evaluation studies, but also that it gives operational advantages over the previous generation of evaluation instrume...
Stakeholders in the modeling and simulation (M&S) community organized a workshop at the 2019 Annual Meeting of the Orthopaedic Research Society (ORS) entitled "Reproducibility in Modeling and Simulati...
Although high-resolution manometry (HR_ARM) is commonly used to diagnose defecatory disorders, its intraindividual day-to-day reproducibility is unknown. Since these measurements entail voluntary effo...
In 22 healthy women (35 years [14] mean [SD]) and 53 constipated patients (42 years [13], 46 women), the rectal balloon expulsion time (BET), and anorectal pressures were measured with HR_ARM on 2 day...
Among constipated patients, the anal resting (mean CCC [95%CI] 0.62 [0.43-0.76]) and squeeze pressures (CCC 0.65 [0.47-0.79]), rectoanal gradient during evacuation (CCC 0.42 [0.17-0.62]), and rectal s...
While HR_ARM variables and the BET are reproducible within healthy and constipated persons, the outcome on repeat testing differed in 79% of constipated patients....
Incorporating open science practices has become a priority for submission criteria in the International Journal of Eating Disorders (IJED). In this systematic review, we used the rigor and reproducibi...
For this systematic review, six trained coders examined 1145 articles published from January 2011 to May 2021, including the 5 years prior to the 2016 introduction of the Open Science Foundation artic...
There was evidence of a significant positive relationship between time and total rigor and reproducibility (Total RR) criteria included in IJED articles following the implementation of preregistration...
Although findings indicate that statistical rigor and reproducibility in this field has increased, the lack of direct relationship between open science methods and article visibility for scientists su...
Statistical controversies within science threaten the rigor and reproducibility of published research. Open science practices, including the preregistration of study hypotheses, links to statistical c...
To evaluate multicenter repeatability and reproducibility of T...
MRF experiments were performed on 5 different 3 Tesla MRI scanners at 3 different institutions: University Hospitals Cleveland Medical Center (Cleveland, OH), Brigham and Women's Hospital (Boston, MA)...
The intrascanner variation of values measured using MRF was less than 2% for T...
Prostate MRF measurements of T...
Western blot is a popular biomolecular analysis method for measuring the relative quantities of independent proteins in complex biological samples. However, variability in quantitative western blot da...
This study aimed to validate a semiquantitative electronic food frequency questionnaire (eFFQ) in estimating the intake of a comprehensive list of nutrients and bioactive compounds among adults from s...
Publicly available speech corpora facilitate reproducible research by providing open-access data for participants who have consented/assented to data sharing among different research teams. Such corpo...
In this research note, we introduce the PERCEPT (Perceptual Error Rating for the Clinical Evaluation of Phonetic Targets) corpora, PERCEPT-R (Rhotics) and PERCEPT-GFTA (Goldman-Fristoe Test of Articul...
We demonstrate the use of PERCEPT corpora, PhonBank, and Phon for clinical training and research questions appropriate to child citation speech. Increased use of these tools has the potential to enhan...
There is reason to believe that the favorable measurement properties of the 6‑minute walk test (6MWT) reported for retest reliability and its capability to detect a true change in healthy individuals ...
Immediately before postacute rehabilitation, 50 LuTXr completed 6MWT testing twice, separated by 1-2 workdays (retest reliability), and were reassessed after completion of rehabilitation 2 months late...
Baseline retest 6‑minute walk distance (6MWD) and the age-related predicted walking distance (6MWD%...
The 6MWT overall represents a reliable functional performance tool in LuTXr that is sensitive to detect changes in physical performance as a result of medical postacute rehabilitation....