questionsmedicales.fr
Maladies du système immunitaire
Réaction transfusionnelle
Réaction transfusionnelle : Questions médicales fréquentes
Termes MeSH sélectionnés :
DNA Copy Number Variations
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"name": "Comment diagnostiquer une réaction transfusionnelle ?",
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"text": "Le diagnostic repose sur l'observation des symptômes et des tests sanguins."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour confirmer une réaction ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de compatibilité et des analyses de sang sont effectués."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une réaction ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, frissons, éruptions cutanées et douleurs lombaires sont des signes courants."
}
},
{
"@type": "Question",
"name": "Quand doit-on suspecter une réaction transfusionnelle ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Si des symptômes apparaissent dans les heures suivant la transfusion."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'historique médical dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
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{
"@type": "Question",
"name": "Quels sont les symptômes courants d'une réaction transfusionnelle ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, frissons, éruptions cutanées, douleurs thoraciques et hypotension."
}
},
{
"@type": "Question",
"name": "Les réactions transfusionnelles provoquent-elles des douleurs ?",
"position": 7,
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"@type": "Question",
"name": "Peut-on avoir des symptômes respiratoires ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des difficultés respiratoires peuvent se manifester dans certains cas."
}
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{
"@type": "Question",
"name": "Les éruptions cutanées sont-elles fréquentes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des éruptions cutanées peuvent apparaître après une transfusion."
}
},
{
"@type": "Question",
"name": "Comment différencier une réaction allergique d'une transfusion ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les réactions allergiques sont souvent localisées, tandis que les transfusionnelles sont systémiques."
}
},
{
"@type": "Question",
"name": "Comment prévenir les réactions transfusionnelles ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Assurer une compatibilité sanguine rigoureuse et un suivi des antécédents du patient."
}
},
{
"@type": "Question",
"name": "Quel rôle joue le consentement éclairé ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le consentement éclairé informe le patient des risques associés aux transfusions."
}
},
{
"@type": "Question",
"name": "Les tests de compatibilité sont-ils obligatoires ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils sont essentiels pour minimiser le risque de réactions transfusionnelles."
}
},
{
"@type": "Question",
"name": "Comment former le personnel médical à la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des formations régulières sur les protocoles transfusionnels sont nécessaires."
}
},
{
"@type": "Question",
"name": "Les banques de sang effectuent-elles des tests préventifs ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles réalisent des tests pour détecter des anticorps et des infections."
}
},
{
"@type": "Question",
"name": "Quel est le traitement immédiat d'une réaction transfusionnelle ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Arrêter la transfusion et administrer des antihistaminiques ou des corticostéroïdes."
}
},
{
"@type": "Question",
"name": "Faut-il surveiller le patient après une réaction ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance étroite est nécessaire pour détecter d'éventuelles complications."
}
},
{
"@type": "Question",
"name": "Les fluides intraveineux sont-ils nécessaires ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des fluides peuvent être administrés pour maintenir la pression artérielle."
}
},
{
"@type": "Question",
"name": "Quand utiliser des médicaments immunosuppresseurs ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "En cas de réactions sévères, des immunosuppresseurs peuvent être envisagés."
}
},
{
"@type": "Question",
"name": "Les transfusions futures nécessitent-elles des précautions ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests supplémentaires et une surveillance accrue sont recommandés."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles d'une réaction transfusionnelle ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent l'insuffisance rénale, le choc et les infections."
}
},
{
"@type": "Question",
"name": "Comment l'insuffisance rénale se manifeste-t-elle ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut se manifester par une diminution de la production d'urine et un œdème."
}
},
{
"@type": "Question",
"name": "Le choc peut-il être fatal ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le choc anaphylactique ou septique peut être mortel sans traitement rapide."
}
},
{
"@type": "Question",
"name": "Les infections sont-elles une préoccupation après une transfusion ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections virales ou bactériennes peuvent survenir après une transfusion."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications post-transfusionnelles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une prise en charge rapide et appropriée est cruciale pour limiter les séquelles."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de réactions transfusionnelles ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antécédents de transfusions, immunodépression et incompatibilité sanguine augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les patients âgés sont-ils plus à risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients âgés peuvent avoir un risque accru de complications transfusionnelles."
}
},
{
"@type": "Question",
"name": "Les femmes enceintes sont-elles plus susceptibles ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent développer des anticorps anti-Rh, augmentant le risque lors de transfusions."
}
},
{
"@type": "Question",
"name": "Les patients ayant des maladies auto-immunes sont-ils à risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent avoir une réponse immunitaire exacerbée aux transfusions."
}
},
{
"@type": "Question",
"name": "Les transfusions multiples augmentent-elles le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les transfusions répétées augmentent le risque de sensibilisation et de réactions."
}
}
]
}
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When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes aris...
Copy number variations (CNVs) play crucial roles in physiological and pathological processes, including cancer. However, the functional implications of somatic CNVs in tumor progression and evolution ...
Starting from 7352 copy number profiles across 33 different cancer types, we infer the pathogenicity of each CNV and perform both intra- and inter-tumor analyses to predict the functional impact of di...
Our analysis uncovered large heterogeneity among different tumors suggesting in many cases distinct genetic drivers of tumorigenesis. Recurrent genomic alterations frequently coincide with dysfunction...
This study contributes to elucidate the functional impact of pathogenic CNVs in tumor progression and sheds light on their potential as prognostic markers in specific cancer types....
Copy number variations (CNV) may represent a significant proportion of SPG4 and SPG3A diagnosis, the most frequent autosomal dominant subtypes of hereditary spastic paraplegias (HSP). We aimed to asse...
Copy number variants (CNVs), duplications and deletions of genomic sequences, contribute to evolutionary adaptation but can also confer deleterious effects and cause disease. Whereas the effects of am...
Eating disorders (EDs) are complex, multifactorial psychiatric conditions. Previous studies identified pathogenic copy number variations associated with NDDs (NDD-CNVs) in ED patients. However, no sta...
Using array comparative genomic hybridization (aCGH), we conducted a high-resolution CNV analysis of 71 severe female ED patients and 1045 female controls. According to the American College of Medical...
Of the samples analyzed with aCGH, 70 severe ED patients (98.6%) and 1036 controls (99.1%) passed our quality control filtering. We obtained 189 and 2539 rare CNVs from patients and controls, respecti...
Our study provides the first preliminary evidence that NDD-CNVs may confer risk for severe EDs. The pathophysiology may involve synaptic dysfunction....
Circulating cell-free DNA (cfDNA) is a noninvasive substitute to liver biopsy for hepatocellular carcinoma (HCC) molecular profiling. This study aimed to use cfDNA to investigate copy number variation...
Real-Time Polymerase Chain Reaction was used to determine the CNV and cfDNA integrity index in 100 HCC patients....
CNV gain in BCL9 and RPS6KB1 genes was detected in 14% and 24% of patients, respectively. Gain in CNV of BCL9 associated with risk of HCC in alcohol drinkers and hepatitis C seropositivity. In patient...
cfDNA was used to detect BCL9 and RPS6KB1 CNVs, which influence prognosis and can be used as independent predictors of HCC patient survival....
Venous thromboembolism (VTE) is a common disease with high heritability. However, only a small portion of the genetic variance of VTE can be explained by known genetic risk factors. Neutrophil extrace...
Mitochondrial DNA (mtDNA) copy number is associated with tumor activity and carcinogenesis. This study was undertaken to investigate mtDNA copy number in papillary thyroid cancer (PTC) tissues and to ...
DNA was extracted from 105 PTC tissues and 67 control thyroid tissues, and mtDNA copy number mtDNA oxidative damage were determined using qPCR techniques....
Overall, the relative mtDNA copy number was significantly higher in PTC patients (p < 0.001). The risk of developing PTC increased significantly across the tertiles of mtDNA copy number (p trend < 0.0...
Our results indicated that the augmentation of mtDNA content plays a significant role during the initiation of thyroid cancer, and it might represent a potential biomarker for predicting the risk of P...
Considering the essential roles that genetic factors play in azoospermia and oligospermia, this study aims to identify abnormal chromosomes using karyotyping and CNVs and elucidate the associated gene...
A total of 1157 azoospermia and oligospermia patients were recruited, of whom, 769 and 674 underwent next-generation sequencing (NGS) to identify CNVs and routine G-band karyotyping, respectively....
First, 286 patients were co-analyzed using CNV sequencing (CNV-seq) and karyotyping. Of the 725 and 432 patients with azoospermia and oligospermia, 33.8% and 48.9% had abnormal karyotypes and CNVs, re...
Sex chromosome and autosomal CNV loci, such as Xp22.31 and 2p24.3, as well as the associated genes, such as VCX and NACAP9, could be candidate spermatogenesis genes. The high-frequency abnormal karyot...
Copy number variation (CNV) is a type of structural variation, which is a gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity of CNVs are required to realize ...
From single nucleotide polymorphism (SNP), gene and region dimensions, we collected 79 informative features that quantitatively describe the characteristics of CNV, such as CNV length, the number of p...
The performance of the dbCNV suggest that functional deleteriousness-based model of CNV is a promising approach to support the classification prediction and to further understand the pathogenic mechan...