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"description": "Comment identifier un inducteur du CYP2D6 ?\nQuels tests sont utilisés pour évaluer l'activité du CYP2D6 ?\nQuels signes indiquent une induction du CYP2D6 ?\nPeut-on mesurer l'activité du CYP2D6 ?\nQuels médicaments sont des inducteurs connus ?",
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{
"@type": "Question",
"name": "Comment identifier un inducteur du CYP2D6 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'identification se fait par l'analyse des médicaments et leur effet sur le métabolisme."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité du CYP2D6 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des dosages de médicaments peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une induction du CYP2D6 ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une diminution de l'efficacité des médicaments métabolisés par CYP2D6 peut indiquer une induction."
}
},
{
"@type": "Question",
"name": "Peut-on mesurer l'activité du CYP2D6 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'activité peut être mesurée par des tests de métabolisme de médicaments spécifiques."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont des inducteurs connus ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme la rifampicine et la carbamazépine sont des inducteurs connus."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent résulter d'une induction du CYP2D6 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une induction peut entraîner une réduction de l'efficacité des médicaments, causant des symptômes de maladie."
}
},
{
"@type": "Question",
"name": "Comment l'induction affecte-t-elle les médicaments ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut réduire la concentration plasmatique des médicaments, diminuant leur effet thérapeutique."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires liés aux inducteurs ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des effets secondaires peuvent survenir si les médicaments perdent leur efficacité."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques peuvent alerter sur une induction ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes de non-réponse au traitement peuvent alerter sur une induction du CYP2D6."
}
},
{
"@type": "Question",
"name": "L'induction peut-elle causer des symptômes d'intoxication ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, si des médicaments sont sous-dosés, cela peut entraîner des symptômes d'intoxication."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'induction du CYP2D6 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les inducteurs connus et surveiller les interactions médicamenteuses."
}
},
{
"@type": "Question",
"name": "Les patients doivent-ils être informés des inducteurs ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'éducation des patients sur les inducteurs est cruciale pour éviter des complications."
}
},
{
"@type": "Question",
"name": "Quelles précautions prendre lors de la prescription ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Évaluer les antécédents médicamenteux et les interactions potentielles avant de prescrire."
}
},
{
"@type": "Question",
"name": "Les médecins doivent-ils surveiller les inducteurs ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance régulière des médicaments inducteurs est recommandée."
}
},
{
"@type": "Question",
"name": "Y a-t-il des recommandations pour les prescripteurs ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des lignes directrices existent pour éviter les interactions avec les inducteurs."
}
},
{
"@type": "Question",
"name": "Comment gérer l'induction du CYP2D6 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est essentiel d'ajuster les doses des médicaments affectés par l'induction."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des inhibiteurs du CYP2D6 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des inhibiteurs peuvent être utilisés pour contrer l'effet des inducteurs."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont souvent ajustés ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antidépresseurs et les antipsychotiques sont souvent ajustés en cas d'induction."
}
},
{
"@type": "Question",
"name": "Y a-t-il des alternatives aux inducteurs ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des médicaments non inducteurs peuvent être prescrits pour éviter l'interaction."
}
},
{
"@type": "Question",
"name": "Comment surveiller l'efficacité du traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suivis réguliers et des dosages de médicaments sont nécessaires pour évaluer l'efficacité."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec l'induction ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent une inefficacité thérapeutique et des effets indésirables."
}
},
{
"@type": "Question",
"name": "L'induction peut-elle entraîner des hospitalisations ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des hospitalisations peuvent être nécessaires en cas de complications graves."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés à l'induction ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les risques incluent des interactions médicamenteuses et des effets secondaires graves."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées à l'induction ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est crucial d'ajuster les traitements et de surveiller les patients de près."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications à long terme ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications à long terme peuvent inclure des effets résiduels sur le métabolisme."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque d'induction ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'utilisation de certains médicaments et des variations génétiques."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il l'induction du CYP2D6 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge peut affecter le métabolisme et la réponse aux inducteurs."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie jouent-elles un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme l'alcool et le tabac peuvent influencer l'induction."
}
},
{
"@type": "Question",
"name": "Y a-t-il des prédispositions génétiques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines variations génétiques peuvent augmenter le risque d'induction."
}
},
{
"@type": "Question",
"name": "Les interactions médicamenteuses sont-elles un facteur ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les interactions avec d'autres médicaments peuvent augmenter le risque d'induction."
}
}
]
}
]
}
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Publications dans "Inducteurs du cytochrome P-450 CYP2D6" :
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Publications dans "Inducteurs du cytochrome P-450 CYP2D6" :
School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Biostatistics & Epidemiology Core, Division of Health Services and Outcomes Research, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Division of Developmental and Behavioral Sciences, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Publications dans "Inducteurs du cytochrome P-450 CYP2D6" :
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Publications dans "Inducteurs du cytochrome P-450 CYP2D6" :
Mental Health Neuroscience Research Department, Division of Psychiatry, University College London, London, UK. e.bramon@ucl.ac.uk.
Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and Maudsley NHS Foundation Trust, London, UK. e.bramon@ucl.ac.uk.
Institute of Cognitive Neuroscience, University College London, London, UK. e.bramon@ucl.ac.uk.
Publications dans "Inducteurs du cytochrome P-450 CYP2D6" :
Intramedullary bone-lengthening nails have become increasingly popular. The 2 most used and successful nails are the FITBONE and the PRECICE nails. Uniform reporting is lacking on complications of int...
We performed a retrospective review of patients operated on with intramedullary lengthening nails at 2 hospitals. We included only lower limb lengthening with FITBONE and PRECICE nails. Recorded patie...
314 segments in 257 patients were included. The FITBONE nail was predominantly used (75%), and most of the lengthenings were performed in the femur (80%). 53% of the patients had complications. 269 co...
Complications with intramedullary bone lengthening nails were more frequent than has previously been reported, with 53% of patients sustaining a complication. Future studies need to document the compl...
The objective of this retrospective study was to assess the effect of the nail to canal ratio and the number and configuration of distal locking screws in bone healing in tibial shaft fractures....
We analyzed 223 consecutive tibial shaft fractures treated with reamed intramedullary nailing between January 2014 and December 2020. We recorded and evaluated the nail to canal ratio (NCR) and the nu...
Bone union was achieved in 195 (87.44%) patients. Uni- and bivariate analyses showed that bone union increased significantly with larger NCR (p = 0.0001) and a greater number of locking planes (p = 0....
Our findings suggest that in tibial shaft fractures treated with intramedullary nailing, NCR should be equal to or greater than 0.79. Additionally, distal locking screws should be used with a biplanar...
A 34-year-old man with a distal tibia bone defect was treated with an intramedullary bone transport nail (Precice Bone Transport System, NuVasive). During planned removal after successful treatment, 7...
When planning for implant removal, surgeons should be aware of potential intraoperative disconnection of subcomponents of this magnetic bone transport nail and ensure that equipment for retrieval (e.g...
Closed reamed locked intramedullary nailing has been the treatment of choice for most of femoral shaft fractures. A high union rate with a low complication rate is generally predictable. For an asepti...
From July 2011 to March 2019, 48 consecutive adult patients (average, 38 years; range, 19-67 years) with aseptic femoral shaft nonunions after intramedullary nailing treatment were studied. All femora...
Forty-one patients were followed for an average of 2.8 years (85.4%; range, 1.9-4.5 years) and all fractures healed. The union rate was 100% (41/41, p < 0.001) with a union time of an average of 3.4 m...
The described modified bone grafting technique may effectively improve a union rate of exchange femur nailing while the surgical procedure is not complicated. It may therefore be used concomitantly in...
This retrospective study aimed to assess the impact of distal nail placement on misalignment and healing rates in distal tibial fractures....
We reviewed all patients with distal tibial fracture treated with intramedullary nailing between 2015 and 2021, and a minimum follow-up of 12 months. Distal nail positioning was determined according t...
Out of the 62 patients included, 56 (90.3%) show bone union without additional procedure, 3 (4.8%) with dynamization, and 3 (4.8%) showed non-union. Twenty-one (33.8%) presented misalignment, with val...
In intramedullary nailing of distal tibial fractures, distal positioning of the nail slightly lateral to the center of the talus in the coronal plane and slightly posterior in the sagittal plane (zone...
In this study, we treated infected ankle bone defects with the induced membrane two-stage technique. The ankle was fused with a retrograde intramedullary nail in the second stage, and the aim of this ...
Elastic stable intramedullary nailing (ESIN) internal fixation is used clinically to treat pathological fractures of bone cysts in children. However, one of the most important complications was remova...
To evaluate the effectiveness of a sequential internal fixation strategy and intramedullary nailing with plate augmentation (IMN/PA) for bone reconstruction in the management of infected femoral shaft...
We performed a retrospective descriptive cohort study of 21 patients (mean age, 36.4 years) with infected bone defects of the femoral shaft treated by the Masquelet technique with a minimum follow-up ...
The median and quartiles of bone defect length was 7 (4.75-9.5) cm. Four patients required iterative debridement for infection recurrence after T1. The median of interval between T1 and T2 was 10 (9-1...
For infected femoral shaft bone defects treated by the Masquelet technique, sequential internal fixation and IMN/PA for the reconstruction can provide excellent mechanical stability, which is benefici...
The task faced by surgeons becomes significantly more challenging when they encounter lower extremity bone defects due to a variety of causes requiring lengthening. The most discussed and successful a...
The data were collected from PubMed, Cochrane Library, Embase, and the Web of Science for all available studies comparing the outcomes of Ilizarov technique alone and LON technique (from January 1, 19...
This review included thirteen studies comprising a total of 629 patients.The external fixation index (month/cm) was significantly smaller in the LON technique compared to the Ilizarov technique alone ...
Our findings indicate that patients treated with the LON technique experienced significantly shorter external fixation durations and a lower incidence of complications (e.g., pin tract infections and ...
The treatment of infected non-unions of the femur and the tibia remains difficult and requires control of the infection and successful bone healing. Antimicrobial coating of intramedullary nails promi...