Titre : Cytochrome P-450 CYP2C9

Cytochrome P-450 CYP2C9 : Questions médicales fréquentes

Termes MeSH sélectionnés :

Constipation
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profils métaboliques peut aider à évaluer les interactions." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour le CYP2C9 ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de métabolisme hépatique et des analyses sanguines sont utilisés." } }, { "@type": "Question", "name": "Quels symptômes d'une mauvaise métabolisation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des nausées, des saignements ou des réactions allergiques peuvent survenir." } }, { "@type": "Question", "name": "Comment reconnaître une surdose de médicaments ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme des vertiges, des saignements ou des douleurs abdominales peuvent indiquer une surdose." } }, { "@type": "Question", "name": "Quels signes d'une interaction médicamenteuse ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des effets secondaires inattendus ou une efficacité réduite des médicaments peuvent être des signes." } }, { "@type": "Question", "name": "Quels symptômes d'une carence en CYP2C9 ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Une carence peut entraîner des effets indésirables graves lors de l'utilisation de certains médicaments." } }, { "@type": "Question", "name": "Quels symptômes d'une toxicité médicamenteuse ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme des éruptions cutanées, des troubles gastro-intestinaux peuvent apparaître." } }, { "@type": "Question", "name": "Comment prévenir les effets indésirables ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi régulier et des tests génétiques peuvent aider à prévenir les effets indésirables." } }, { "@type": "Question", "name": "Quels conseils pour les patients sous anticoagulants ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Les patients doivent être informés des signes de saignement et des interactions possibles." } }, { "@type": "Question", "name": "Comment éviter les interactions médicamenteuses ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Informer les médecins de tous les médicaments pris aide à éviter les interactions." } }, { "@type": "Question", "name": "Quels tests préventifs pour CYP2C9 ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques avant le traitement peuvent aider à prévenir des complications." } }, { "@type": "Question", "name": "Comment sensibiliser sur CYP2C9 ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Des campagnes d'information sur les risques et les tests génétiques peuvent sensibiliser." } }, { "@type": "Question", "name": "Comment ajuster les doses pour CYP2C9 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les doses doivent être ajustées en fonction des tests génétiques et des réponses cliniques." } }, { "@type": "Question", "name": "Quels médicaments sont métabolisés par CYP2C9 ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments comme la warfarine, le phénytoïne et certains AINS sont métabolisés par CYP2C9." } }, { "@type": "Question", "name": "Comment gérer les interactions médicamenteuses ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Il est essentiel de surveiller les interactions et d'ajuster les traitements en conséquence." } }, { "@type": "Question", "name": "Quels traitements alternatifs pour les déficients ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des alternatives médicamenteuses avec un métabolisme différent peuvent être envisagées." } }, { "@type": "Question", "name": "Comment traiter une surdose liée à CYP2C9 ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement peut inclure l'arrêt du médicament et des soins symptomatiques." } }, { "@type": "Question", "name": "Quelles complications d'une mauvaise métabolisation ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme des saignements graves ou des réactions allergiques peuvent survenir." } }, { "@type": "Question", "name": "Quels risques d'une surdose ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Une surdose peut entraîner des complications graves, y compris des dommages organiques." } }, { "@type": "Question", "name": "Comment gérer les complications liées à CYP2C9 ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Une surveillance étroite et un ajustement des traitements sont nécessaires pour gérer les complications." } }, { "@type": "Question", "name": "Quels effets à long terme d'une déficience ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Une déficience peut entraîner des effets à long terme sur la santé, comme des maladies chroniques." } }, { "@type": "Question", "name": "Quelles complications liées aux interactions ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Les interactions peuvent provoquer des complications comme des hospitalisations ou des traitements prolongés." } }, { "@type": "Question", "name": "Quels facteurs influencent CYP2C9 ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs comme la génétique, l'âge et l'alimentation influencent l'activité de CYP2C9." } }, { "@type": "Question", "name": "Comment l'âge affecte CYP2C9 ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "L'âge avancé peut réduire l'activité de CYP2C9, augmentant le risque d'effets indésirables." } }, { "@type": "Question", "name": "Quel rôle de l'alimentation sur CYP2C9 ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Certaines substances alimentaires peuvent inhiber ou induire l'activité de CYP2C9." } }, { "@type": "Question", "name": "Quels médicaments augmentent le risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments comme les antifongiques peuvent inhiber CYP2C9, augmentant le risque d'effets indésirables." } }, { "@type": "Question", "name": "Comment les maladies hépatiques affectent CYP2C9 ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Les maladies hépatiques peuvent réduire l'activité de CYP2C9, affectant le métabolisme des médicaments." } } ] } ] }

Sources (1109 au total)

Colonic TRPV4 overexpression is related to constipation severity.

Chronic constipation is prevalent and involves both colon sensitivity and various changes in intestinal bacteria, particularly mucosa-associated microflora. Here we examined regulatory mechanisms of T... Colon epithelial cell lines were co-cultured with various enterobacteria (bacterial components and supernatant), folate, LPS, or short chain fatty acids. TRPV4 expression levels and promoter DNA methy... Co-culture of CCD841 cells with P. acnes, C. perfringens, or S. aureus transiently decreased TRPV4 expression but did not induce methylation. Co-culture with clinical isolates and standard strains of ... Colon epithelium cells had increased TRPV4 expression upon co-culture with K. oxytoca, E. faecalis, or E. coli supernatants, as well as TNFα-stimulated TNFαR1 expression via a pathway other than p38. ...

The effect of aroma massage on constipation in elderly individuals.

Constipation is a health problem commonly seen in the elderly individuals. Abdominal massage is thought to stimulate the rectal loading by increasing intra-abdominal pressure.... To determine effects of aromatherapy massage on constipation in the elderly individuals.... Forty eight elderly individuals with constipation were randomized to aromatherapy massage, and control groups. Massage was applied with oil blend to the experimental group during 3 weeks, once a day a... During aroma massage and after aroma massage in intervention group, mean scores related to 'defecation number', 'amount of feces' and 'consistency of feces' were increased and these increases were sta... It was determined that aroma massage practice has increased 'frequency of defecation', 'amount of feces' and 'consistency of feces' but decreased the 'straining during defecation' and 'feeling of inco...

Severity of Nocturia and Constipation in Patients With Ulcerative Colitis.

To investigate the association between nocturia and constipation in patients with ulcerative colitis (UC). Constipation has recently been recognized as an important symptom in patients with UC. Althou... Consecutive series of 290 Japanese patients with UC, Information on constipation, nocturia, and lifestyle habits was obtained using self-administered questionnaires. The definition of constipation was... Among all of the UC patients, the prevalence of mild nocturia, serious nocturia, and constipation was 35.2%, 26.9%, and 12.4%, respectively. The prevalence of constipation in the none, mild, and serio... The severity of nocturia is positively associated with constipation, and physicians should consider the interrelationships between nocturia and constipation in managing UC patients....

The role of rectal ultrasound in children with functional constipation.

The study aimed primarily to compare the transverse rectal diameter in children with functional constipation (FC) and children without constipation in different age groups, and between cases of consti... A controlled prospective study, including a total of 100 children between the ages of 2 and 11 years, who were divided into 50 patients suffering from constipation according to Rome IV criteria and 50... Initial rectal diameter was significantly different between cases (3.55 cm (interquartile range, IQR), 3.2-4) and controls (2.3 cm (IQR, 1.8-2.5)), P value < 0.001, and it was also significantly diffe... Ultrasound measurement of rectal diameter is an important tool to diagnose and follow-up functional constipation in children. Different values of rectal diameter are found between those above and belo...

The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial.

Gut microbiota dysbiosis in patients with chronic kidney disease on haemodialysis (CKD-HD) creates an increase in proteolytic bacteria activity, leading to an increase in the production of uraemic tox... This was a double-blinded randomized controlled clinical trial with a parallel design involving haemodialysis patients. We included chronic haemodialysis patients with gastrointestinal complaints, dif... We included 60 patients (30 intervention; median age of 51.23 (13.57) years, 33.3% male; 30 control; median age of 52.33 (11.29) years, 36.7% male). There was no significant difference in terms of pre... Two months of synbiotic supplementation did not lower indoxyl sulphate toxin levels. Nevertheless, it had a major effect in improving constipation and quality of life affected by constipation in patie... NCT04527640 (date of first registration: 26/08/2020)....