Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk.
Adult
Alcoholism
/ diagnostic imaging
Conditioning, Classical
/ physiology
Conditioning, Operant
/ physiology
Cues
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nucleus Accumbens
/ diagnostic imaging
Recurrence
Risk
Severity of Illness Index
Transfer, Psychology
/ physiology
Alcohol dependence
Human neuroimaging
Nucleus accumbens
Pavlovian-instrumental transfer
Relapse
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
30
09
2016
accepted:
02
12
2017
pubmed:
10
1
2018
medline:
27
8
2019
entrez:
10
1
2018
Statut:
ppublish
Résumé
The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients (t = - 3.86, p < .001), but not in healthy controls (t = - 0.92, p = .36). This behavioral inhibition was associated with neural activation in the nucleus accumbens (NAcc) (t
Identifiants
pubmed: 29313106
doi: 10.1007/s00406-017-0860-4
pii: 10.1007/s00406-017-0860-4
doi:
Banques de données
ClinicalTrials.gov
['NCT01679145']
Types de publication
Journal Article
Langues
eng
Pagination
295-308Références
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