Decreased body mass index during treatment with sodium oxybate in narcolepsy type 1.
central nervous system stimulants
dyssomnias
hydroxybutyrates
hypersomnia
weight loss
Journal
Journal of sleep research
ISSN: 1365-2869
Titre abrégé: J Sleep Res
Pays: England
ID NLM: 9214441
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
02
11
2017
revised:
31
01
2018
accepted:
01
02
2018
pubmed:
6
3
2018
medline:
26
3
2020
entrez:
6
3
2018
Statut:
ppublish
Résumé
Narcolepsy type 1 is characterised by an increase in body weight after disease onset, frequently leading to obesity. It was suggested that this weight gain may be counteracted by treatment with sodium oxybate. We here provide longitudinal body mass index data of patients with narcolepsy type 1 after starting treatment with sodium oxybate, compared with patients in whom treatment with modafinil was initiated. Eighty-one individuals with narcolepsy type 1 fulfilled the entry criteria for this retrospective study: 59 had newly started treatment with sodium oxybate and 22 had newly started modafinil. Gender-specific differences between both treatment groups were compared using Student's t tests and mixed effect modeling. Patients using sodium oxybate lost weight, with a mean body mass index decrease of 2.56 kg/m
Identifiants
pubmed: 29504180
doi: 10.1111/jsr.12684
pmc: PMC7378953
doi:
Substances chimiques
Anesthetics, Intravenous
0
Sodium Oxybate
7G33012534
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12684Informations de copyright
© 2018 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.
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