Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Apoptosis
/ drug effects
Biomarkers
/ metabolism
Cell Line, Tumor
Corpus Striatum
/ pathology
Disease Models, Animal
Dopaminergic Neurons
/ metabolism
Glial Fibrillary Acidic Protein
/ metabolism
Gliosis
/ complications
Heme Oxygenase-1
/ metabolism
Humans
Inflammation Mediators
/ metabolism
Male
Mice, Inbred C57BL
Motor Activity
/ drug effects
NF-E2-Related Factor 2
/ metabolism
Neuroprotective Agents
/ pharmacology
Neurotoxins
/ toxicity
Oxidative Stress
/ drug effects
Parkinson Disease
/ complications
Plant Extracts
/ pharmacology
Rotenone
Signal Transduction
/ drug effects
Substantia Nigra
/ pathology
Tyrosine 3-Monooxygenase
/ metabolism
Up-Regulation
/ drug effects
alpha-Synuclein
/ metabolism
Gintonin
MPTP
Neuroinflammation
Neuroprotection
Nrf2/HO-1 pathway
Parkinson’s disease
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
18
01
2018
accepted:
16
03
2018
pubmed:
21
4
2018
medline:
2
4
2019
entrez:
21
4
2018
Statut:
ppublish
Résumé
Gintonin, a ginseng-derived glycolipoprotein isolated from ginseng, has been shown to be neuroprotective in several neurological disorders such as Alzheimer's disease models and depressive-like behaviors. In this study, we sought to investigate the potential protective mechanisms of gintonin in an in vivo MPTP and in vitro MPP
Identifiants
pubmed: 29675576
doi: 10.1007/s12035-018-1020-1
pii: 10.1007/s12035-018-1020-1
doi:
Substances chimiques
Biomarkers
0
Glial Fibrillary Acidic Protein
0
Inflammation Mediators
0
NF-E2-Related Factor 2
0
Neuroprotective Agents
0
Neurotoxins
0
Plant Extracts
0
alpha-Synuclein
0
gintonin
0
Rotenone
03L9OT429T
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9P21XSP91P
Heme Oxygenase-1
EC 1.14.14.18
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-55Subventions
Organisme : National Research Foundation of Korea
ID : 2016M3C7A1904391
Organisme : National Research Foundation of Korea
ID : 2016M3C7A1913845
Commentaires et corrections
Type : RetractionIn
Références
Mol Neurodegener. 2017 Jan 24;12(1):10
pubmed: 28118852
J Neurol Sci. 2018 Mar 15;386:39-45
pubmed: 29406964
Mol Neurobiol. 2012 Oct;46(2):475-86
pubmed: 22773138
J Neurophysiol. 2015 Mar 1;113(5):1493-500
pubmed: 25505112
Antioxid Redox Signal. 2008 Aug;10(8):1343-74
pubmed: 18522489
PLoS One. 2011 Jan 31;6(1):e16706
pubmed: 21304957
Exp Neurol. 2017 Sep;295:77-87
pubmed: 28552716
Neurosci Lett. 2015 Aug 31;603:19-24
pubmed: 26191656
J Affect Disord. 2017 Jun;215:23-29
pubmed: 28314177
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1165-1170
pubmed: 28028237
Nat Protoc. 2007;2(1):141-51
pubmed: 17401348
J Neural Transm (Vienna). 2003 Oct;110(10):1129-44
pubmed: 14523625
Mol Cells. 2012 Dec;34(6):563-72
pubmed: 23161173
Neuropharmacology. 2017 May 1;117:352-363
pubmed: 28238714
CNS Neurosci Ther. 2017 Jan;23(1):33-44
pubmed: 27421686
Eur J Neurol. 2008 Aug;15(8):865-8
pubmed: 18684311
Eur J Dent. 2014 Apr;8(2):211-215
pubmed: 24966772
Trends Mol Med. 2013 Mar;19(3):187-96
pubmed: 23318001
J Neurochem. 2003 Dec;87(6):1527-34
pubmed: 14713308
Neurosci Lett. 2016 Jan 26;612:256-260
pubmed: 26706688
J Ginseng Res. 2016 Jan;40(1):55-61
pubmed: 26843822
Clin Chim Acta. 2015 Sep 20;449:68-76
pubmed: 26048192
Neuromolecular Med. 2014 Jun;16(2):217-30
pubmed: 24522549
J Neuropathol Exp Neurol. 2005 Jul;64(7):623-8
pubmed: 16042314
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a009316
pubmed: 22229125
J Neural Transm (Vienna). 2007;114(12):1553-7
pubmed: 17676428
PLoS One. 2016 Oct 27;11(10):e0164094
pubmed: 27788145
J Neural Transm (Vienna). 2014 Feb;121(2):171-81
pubmed: 23996276
Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):665-70
pubmed: 14704277
PPAR Res. 2017;2017:4089214
pubmed: 28356907
PLoS One. 2017 Jan 6;12(1):e0169560
pubmed: 28060896
Free Radic Biol Med. 2008 Nov 15;45(10):1375-83
pubmed: 18824091
Behav Brain Res. 2010 Jul 29;211(1):1-10
pubmed: 20211655
Oncol Lett. 2017 Jan;13(1):296-300
pubmed: 28123558
Mol Nutr Food Res. 2016 Oct;60(10):2161-2175
pubmed: 27296520
Free Radic Biol Med. 2013 Sep;62:132-144
pubmed: 23380027
Biochim Biophys Acta. 2010 Jan;1802(1):29-44
pubmed: 19733240
Sci Rep. 2016 Aug 24;6:32206
pubmed: 27553905
Sci Rep. 2017 Sep 29;7(1):12435
pubmed: 28963462
Cold Spring Harb Perspect Med. 2012 Jun;2(6):a008870
pubmed: 22675666
Hum Mol Genet. 2011 Mar 1;20(5):867-79
pubmed: 21138942
Biomed Pharmacother. 2004 Jan;58(1):39-46
pubmed: 14739060
Sci Rep. 2017 Jan 18;7:40753
pubmed: 28098243
Biochim Biophys Acta. 2009 Jul;1792(7):676-87
pubmed: 18930814
Sci Rep. 2016 Apr 20;6:24493
pubmed: 27093924
J Alzheimers Dis. 2012;31(1):207-23
pubmed: 22543851
Front Neuroanat. 2015 Jul 08;9:91
pubmed: 26217195
J Neurol Sci. 2014 May 15;340(1-2):198-207
pubmed: 24768159
Am J Chin Med. 2011;39(1):83-94
pubmed: 21213400
Mol Neurobiol. 2018 Apr;55(4):3067-3078
pubmed: 28466267
Neurosci Lett. 2015 Jan 1;584:356-61
pubmed: 25445364
Phytother Res. 2013 Sep;27(9):1293-9
pubmed: 23109250
Parkinsons Dis. 2011 Mar 15;2011:716871
pubmed: 21461368
FEBS Lett. 2016 May;590(10):1455-66
pubmed: 27086966
Parkinsons Dis. 2011 Feb 22;2011:314082
pubmed: 21403858
J Parkinsons Dis. 2013;3(4):461-91
pubmed: 24252804
Transl Neurodegener. 2016 Jul 22;5:14
pubmed: 27453777
Eur J Neurosci. 2007 Sep;26(6):1500-8
pubmed: 17714494
Mol Cells. 2015 Sep;38(9):796-805
pubmed: 26255830
Neurosci Lett. 2008 Aug 15;441(1):16-20
pubmed: 18586394
Phytomedicine. 2017 Feb 15;25:93-99
pubmed: 28190476
Autophagy. 2013 Jan;9(1):112-4
pubmed: 23075854
Sci Rep. 2017 Jan 20;7:40961
pubmed: 28106099