Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor.
Anti-Bacterial Agents
/ chemical synthesis
Aspergillus
/ chemistry
Biphenyl Compounds
/ chemical synthesis
Cell Culture Techniques
Epigenomics
Fungi
/ genetics
Histone Deacetylase Inhibitors
/ pharmacology
Microbial Sensitivity Tests
Molecular Structure
Staphylococcus aureus
/ drug effects
Vorinostat
/ pharmacology
Marine-derived fungi
antibacterial activity
epigenetic manipulation
Journal
Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
pubmed:
24
4
2018
medline:
17
7
2019
entrez:
24
4
2018
Statut:
ppublish
Résumé
Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL.
Identifiants
pubmed: 29683350
doi: 10.1080/14786419.2018.1465423
doi:
Substances chimiques
Anti-Bacterial Agents
0
Biphenyl Compounds
0
Histone Deacetylase Inhibitors
0
diphenyl
2L9GJK6MGN
Vorinostat
58IFB293JI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM