Perinatal Outcome and Long-Term Neurodevelopment after Intracranial Haemorrhage due to Fetal and Neonatal Alloimmune Thrombocytopenia.
Adolescent
Adult
Blindness
/ etiology
Cerebral Palsy
/ etiology
Child
Child, Preschool
Deafness
/ etiology
Developmental Disabilities
/ etiology
Female
Humans
Infant
Infant, Newborn
Intracranial Hemorrhages
/ complications
Male
Pregnancy
Thrombocytopenia, Neonatal Alloimmune
/ diagnosis
Treatment Outcome
Young Adult
Fetal and neonatal alloimmune thrombocytopenia
Intracranial haemorrhage
Long-term outcome
Neurodevelopment
Journal
Fetal diagnosis and therapy
ISSN: 1421-9964
Titre abrégé: Fetal Diagn Ther
Pays: Switzerland
ID NLM: 9107463
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
11
2017
accepted:
07
03
2018
pubmed:
8
5
2018
medline:
18
7
2019
entrez:
7
5
2018
Statut:
ppublish
Résumé
To evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. We performed an observational cohort study and included all consecutive cases of ICH caused by FNAIT from 1993 to 2015 at Leiden University Medical Centre. Neurological, motor, and cognitive development were assessed at a minimum age of 1 year. The primary outcome was adverse outcome, defined as perinatal death or severe neurodevelopmental impairment (NDI). Severe NDI was defined as any of the following: cerebral palsy (Gross Motor Function Classification System [GMFCS] level ≥II), bilateral deafness, blindness, or severe motor and/or cognitive developmental delay (<-2 SD). In total, 21 cases of ICH due to FNAIT were included in the study. The perinatal mortality rate was 10/21 (48%). Long-term outcome was assessed in 10 children (n = 1 lost to follow-up). Severe and moderate NDI were diagnosed in 6/10 (60%) and 1/10 (10%) of the surviving children. The overall adverse outcome, including perinatal mortality or severe NDI, was 16/20 (80%). The risk of perinatal death or severe NDI in children with ICH due to FNAIT is high. Only screening and effective preventive treatment can avoid this burden.
Identifiants
pubmed: 29730660
pii: 000488280
doi: 10.1159/000488280
pmc: PMC6482979
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
184-191Informations de copyright
© 2018 The Author(s) Published by S. Karger AG, Basel.
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