Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase.
Animals
Behavior, Animal
/ physiology
Brain
Choice Behavior
/ physiology
Conditioning, Operant
/ physiology
Depression
/ chemically induced
Disease Models, Animal
Indoleamine-Pyrrole 2,3,-Dioxygenase
/ genetics
Inflammation
/ chemically induced
Lipopolysaccharides
Mice
Mice, Knockout
Motivation
/ physiology
Reinforcement Schedule
Reward
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
02
01
2018
accepted:
16
04
2018
revised:
18
03
2018
pubmed:
16
5
2018
medline:
12
2
2019
entrez:
16
5
2018
Statut:
ppublish
Résumé
Despite years of research, our understanding of the mechanisms by which inflammation induces depression is still limited. As clinical data points to a strong association between depression and motivational alterations, we sought to (1) characterize the motivational changes that are associated with inflammation in mice, and (2) determine if they depend on inflammation-induced activation of indoleamine 2,3 dioxygenase-1 (IDO1). Lipopolysaccharide (LPS)-treated or spared nerve injured (SNI) wild type (WT) and Ido1
Identifiants
pubmed: 29760410
doi: 10.1038/s41386-018-0075-z
pii: 10.1038/s41386-018-0075-z
pmc: PMC6300560
doi:
Substances chimiques
Indoleamine-Pyrrole 2,3,-Dioxygenase
0
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
364-371Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193522
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073939
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH104694
Pays : United States
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