Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy.
Adult
Aging
/ psychology
Antiretroviral Therapy, Highly Active
/ adverse effects
Bacteria
/ classification
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Cohort Studies
Dysbiosis
/ microbiology
Female
Gastrointestinal Microbiome
HIV
/ genetics
HIV Infections
/ drug therapy
High-Throughput Nucleotide Sequencing
Humans
Middle Aged
Mouth
/ microbiology
Opportunistic Infections
Phylogeny
RNA, Ribosomal, 16S
/ genetics
Saliva
/ microbiology
Viral Load
HIV
aging
disease progression
opportunistic infection
oral microbiome
saliva
Journal
AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
29
5
2018
medline:
27
2
2020
entrez:
30
5
2018
Statut:
ppublish
Résumé
Human immunodeficiency virus (HIV)-associated nonacquired immunodeficiency syndrome (AIDS) conditions, such as cardiovascular disease, diabetes, osteoporosis, and dementia are more prevalent in older than in young adult HIV-infected subjects. Although the oral microbiome has been studied as a window into pathogenesis in aging populations, its relationship to HIV disease progression, opportunistic infections, and HIV-associated non-AIDS conditions is not well understood. We utilized 16S rDNA-based pyrosequencing to compare the salivary microbiome in three groups: (1) Chronically HIV-infected women >50 years of age (aging); (2) HIV-infected women <35 years of age (young adult); and (3) HIV-uninfected age-matched women. We also examined correlations between salivary dysbiosis, plasma HIV RNA, CD4
Identifiants
pubmed: 29808701
doi: 10.1089/AID.2017.0200
pmc: PMC6909750
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
276-286Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000004
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000454
Pays : United States
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