Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors.
Animals
Calcium
/ metabolism
Cells, Cultured
Cocaine
/ pharmacology
Corpus Striatum
/ cytology
Dopamine Uptake Inhibitors
/ pharmacology
Ghrelin
/ metabolism
HEK293 Cells
Humans
Male
Models, Molecular
Neurons
/ cytology
Oleanolic Acid
/ analogs & derivatives
Phosphorylation
Rats
Rats, Sprague-Dawley
Receptors, sigma
/ metabolism
Saponins
/ metabolism
Signal Transduction
/ drug effects
Sigma-1 Receptor
Cross-regulation
Drug addiction
Functional selectivity
G protein-coupled heteroreceptor complex
Neuroendocrine
Receptor heteromer
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
01
12
2017
accepted:
21
05
2018
pubmed:
8
6
2018
medline:
13
7
2019
entrez:
8
6
2018
Statut:
ppublish
Résumé
Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (σ
Identifiants
pubmed: 29876881
doi: 10.1007/s12035-018-1140-7
pii: 10.1007/s12035-018-1140-7
doi:
Substances chimiques
3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl)ester
0
Dopamine Uptake Inhibitors
0
Ghrelin
0
Receptors, sigma
0
Saponins
0
Oleanolic Acid
6SMK8R7TGJ
Cocaine
I5Y540LHVR
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1196-1210Subventions
Organisme : Secretaría de Estado de Investigación, Desarrollo e Innovación
ID : BFU2015-664405-R
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