Identification of six novel susceptibility loci for dyslipidemia using longitudinal exome-wide association studies in a Japanese population.

Adult Aged Ataxin-2 / genetics Carrier Proteins / genetics Cholesterol, HDL / blood Cholesterol, LDL / blood Dyslipidemias / genetics Exome Female GTPase-Activating Proteins / genetics Genetic Loci Humans Intercellular Signaling Peptides and Proteins / genetics Japan Male Middle Aged N-Terminal Acetyltransferase B / genetics Polymorphism, Single Nucleotide Sodium-Phosphate Cotransporter Proteins, Type I / genetics
Dyslipidemia Exome-wide association study Generalized estimating equation HDL-cholesterol LDL-cholesterol Triglyceride

Journal

Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135

Informations de publication

Date de publication:
07 2019
Historique:
received: 11 03 2018
revised: 09 05 2018
accepted: 18 05 2018
pubmed: 8 6 2018
medline: 24 12 2019
entrez: 8 6 2018
Statut: ppublish

Résumé

Recent genome-wide association studies have identified various dyslipidemia-related genetic variants. However, most studies were conducted in a cross-sectional manner. We thus performed longitudinal exome-wide association studies of dyslipidemia in a Japanese population. We used ~244,000 genetic variants and clinical data of 6022 Japanese individuals who had undergone annual health checkups for several years. After quality control, the association of dyslipidemia-related phenotypes with 24,691 single nucleotide polymorphisms (SNPs) was tested using the generalized estimating equation model. In total, 82 SNPs were significantly (P < 2.03 × 10

Identifiants

DOI: 10.1016/j.ygeno.2018.05.015 PMID: 29879492
pubmed: 29879492
pii: S0888-7543(18)30158-7
doi: 10.1016/j.ygeno.2018.05.015
pii:
doi:

Substances chimiques

ATXN2 protein, human 0
Ataxin-2 0
CDSN protein, human 0
Carrier Proteins 0
Cholesterol, HDL 0
Cholesterol, LDL 0
GIT2 protein, human 0
GTPase-Activating Proteins 0
Intercellular Signaling Peptides and Proteins 0
NAA25 protein, human 0
SLC17A3 protein, human 0
Sodium-Phosphate Cotransporter Proteins, Type I 0
TCHP protein, human 0
N-Terminal Acetyltransferase B EC 2.3.1.255

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

520-533

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Yoshiki Yasukochi (Y)

Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu 514-8507, Japan; CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan. Electronic address: hyasukou@proof.ocn.ne.jp.

Jun Sakuma (J)

CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan; Computer Science Department, College of Information Science, University of Tsukuba, Tsukuba 305-8573, Japan; RIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan.

Ichiro Takeuchi (I)

CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan; RIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan; Department of Computer Science, Nagoya Institute of Technology, Nagoya 466-8555, Japan.

Kimihiko Kato (K)

Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu 514-8507, Japan; Department of Internal Medicine, Meitoh Hospital, Nagoya 465-0025, Japan.

Mitsutoshi Oguri (M)

Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu 514-8507, Japan; Department of Cardiology, Kasugai Municipal Hospital, Kasugai 486-8510, Japan.

Tetsuo Fujimaki (T)

Department of Cardiovascular Medicine, Inabe General Hospital, Inabe 511-0428, Japan.

Hideki Horibe (H)

Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi 507-8522, Japan.

Yoshiji Yamada (Y)

Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu 514-8507, Japan; CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Identification of six novel susceptibility...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Identification of six novel susceptibility...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines de liaison au poly(A) › Ataxine-2 › Identification of six novel susceptibility...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Identification of six novel susceptibility...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines HDL › Cholestérol HDL › Identification of six novel susceptibility...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Identification of six novel susceptibility...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Identification of six novel susceptibility...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Exome › Identification of six novel susceptibility...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › Identification of six novel susceptibility...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Identification of six novel susceptibility...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of six novel susceptibility...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Identification of six novel susceptibility...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Identification of six novel susceptibility...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Identification of six novel susceptibility...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acetyltransferases › N-terminal acetyltransferases › N-terminal acetyltransferase B › Identification of six novel susceptibility...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Identification of six novel susceptibility...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Symporteurs › Cotransporteurs de sodium-phosphate › Cotransporteurs sodium-phosphate de type I › Identification of six novel susceptibility...