Correlation between relative bacterial activity and lactate dehydrogenase gene expression of co-cultures in vitro.

16S rRNA Biofilm Dental caries/etiology Fusobacteria Lactobacilli Relative bacterial activity ldh-expression

Journal

Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 02 11 2017
accepted: 27 06 2018
pubmed: 8 7 2018
medline: 19 12 2019
entrez: 8 7 2018
Statut: ppublish

Résumé

The present study aims at correlating the relative bacterial activity with the H Well plates were prepared with BHI medium and cultures of Lactobacillus paracasei and Fusobacterium nucleatum. Bacterial growth at 37 °C was measured using a microplate-photometer before and after adding sucrose to the samples. Samples of co-cultures (n = 12) and single-species cultures (n = 3) were taken and pH was assessed. Real-time quantitative PCRs were applied targeting the 16S-gene, the 16S-rRNA, the ldh-gene, and the ldh-mRNA. For L. paracasei with sucrose, an increase in relative bacterial activity (62.8% ± 23.5% [mean, SE]) was observed, while F. nucleatum showed a clear decrease in relative bacterial activity (- 35.0% ± 9.6%). Simultaneously, the H The relative bacterial activity after sucrose pulse showed a significant correlation not only to the acid production (H

Identifiants

pubmed: 29980934
doi: 10.1007/s00784-018-2547-2
pii: 10.1007/s00784-018-2547-2
doi:

Substances chimiques

L-Lactate Dehydrogenase EC 1.1.1.27

Types de publication

Journal Article

Langues

eng

Pagination

1225-1235

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Auteurs

Carolin Walther (C)

Department of Operative Dentistry, Periodontology, and Preventive Dentistry, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. cwalther@ukaachen.de.

Hendrik Meyer-Lueckel (H)

Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Bern, Switzerland.

Georg Conrads (G)

Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.

Marcella Esteves-Oliveira (M)

Department of Operative Dentistry, Periodontology, and Preventive Dentistry, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.

Karsten Henne (K)

Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.

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Classifications MeSH