Relationship between pulse pressure and inflammation with left ventricular diastolic dysfunction in chronic kidney disease patients.
Adult
Aged
Biomarkers
/ blood
Blood Pressure
C-Reactive Protein
/ metabolism
Female
Humans
Inflammation
/ blood
Interleukin-12
/ blood
Interleukin-18
/ blood
Logistic Models
Male
Middle Aged
Multivariate Analysis
Prospective Studies
Randomized Controlled Trials as Topic
Renal Insufficiency, Chronic
/ blood
Risk Factors
Vascular Stiffness
Ventricular Dysfunction, Left
/ blood
arterial stiffness
chronic kidney disease
diastolic dysfunction
inflammation
Journal
Internal medicine journal
ISSN: 1445-5994
Titre abrégé: Intern Med J
Pays: Australia
ID NLM: 101092952
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
12
04
2018
revised:
26
06
2018
accepted:
02
07
2018
pubmed:
12
7
2018
medline:
18
12
2019
entrez:
12
7
2018
Statut:
ppublish
Résumé
Diastolic dysfunction (DD) is an important cause of cardiovascular disease (CVD) mortality in chronic kidney disease (CKD) patients. Non-traditional risk factors, such as arterial stiffness and inflammation, are implicated in the pathogenesis of DD in CKD patients. To determine the association between inflammatory markers (interleukin (IL)-12, IL-18, highly sensitive C-reactive protein (hsCRP)) and non-invasive markers of arterial stiffness (24-h pulse pressure (PP)) with DD in stages 3-4 CKD patients. We performed a sub-analysis of 78 non-diabetic stages 3-4 CKD subjects to determine the relationship between 24-h PP, IL-12, IL-18 and hsCRP with DD. DD was present in 38 subjects (49%). Subjects with DD were significantly older (61.0 ± 1.9 vs 50.2 ± 2.0 years; P < 0.001) and had higher 24-h PP (48(95% confidence interval 45, 52) vs 43(95% confidence interval 41, 45) mmHg; P < 0.005); 24-h PP was associated with DD (P = 0.02), but this was no longer significant after adjustment for age (P = 0.31). Serum IL-12, IL-18 and hsCRP levels were not significantly different between subjects with or without DD. Asymptomatic subclinical DD was present in 50% of a cohort of stages 3-4 CKD patients but was not associated with IL-12, IL-18 or hsCRP. The association between 24-h PP and DD was no longer apparent following adjustment for age, but given the small sample size, our findings will need to be explored in larger-sized cohorts of individuals with moderate-stage CKD.
Sections du résumé
BACKGROUND
BACKGROUND
Diastolic dysfunction (DD) is an important cause of cardiovascular disease (CVD) mortality in chronic kidney disease (CKD) patients. Non-traditional risk factors, such as arterial stiffness and inflammation, are implicated in the pathogenesis of DD in CKD patients.
AIM
OBJECTIVE
To determine the association between inflammatory markers (interleukin (IL)-12, IL-18, highly sensitive C-reactive protein (hsCRP)) and non-invasive markers of arterial stiffness (24-h pulse pressure (PP)) with DD in stages 3-4 CKD patients.
METHODS
METHODS
We performed a sub-analysis of 78 non-diabetic stages 3-4 CKD subjects to determine the relationship between 24-h PP, IL-12, IL-18 and hsCRP with DD.
RESULTS
RESULTS
DD was present in 38 subjects (49%). Subjects with DD were significantly older (61.0 ± 1.9 vs 50.2 ± 2.0 years; P < 0.001) and had higher 24-h PP (48(95% confidence interval 45, 52) vs 43(95% confidence interval 41, 45) mmHg; P < 0.005); 24-h PP was associated with DD (P = 0.02), but this was no longer significant after adjustment for age (P = 0.31). Serum IL-12, IL-18 and hsCRP levels were not significantly different between subjects with or without DD.
CONCLUSION
CONCLUSIONS
Asymptomatic subclinical DD was present in 50% of a cohort of stages 3-4 CKD patients but was not associated with IL-12, IL-18 or hsCRP. The association between 24-h PP and DD was no longer apparent following adjustment for age, but given the small sample size, our findings will need to be explored in larger-sized cohorts of individuals with moderate-stage CKD.
Substances chimiques
Biomarkers
0
Interleukin-18
0
Interleukin-12
187348-17-0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
240-247Subventions
Organisme : Hollywood Private Hospital Research Foundation
ID : 303151, 1136046, RF026
Organisme : National Health and Medical Research Council
ID : GNT1039149, 303151, 1136046
Organisme : Pfizer CVL
Organisme : National Health & Medical Research Council Post-Graduate Scholarship
Organisme : Jacquot Research Entry Scholarship
Organisme : Jacquot Research Establishment Award
Informations de copyright
© 2018 Royal Australasian College of Physicians.