Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na
cardiac arrhythmia
heart failure
mechanistic modeling
Journal
Wiley interdisciplinary reviews. Systems biology and medicine
ISSN: 1939-005X
Titre abrégé: Wiley Interdiscip Rev Syst Biol Med
Pays: United States
ID NLM: 101516550
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
22
03
2018
revised:
29
05
2018
accepted:
16
06
2018
pubmed:
18
7
2018
medline:
25
6
2020
entrez:
18
7
2018
Statut:
ppublish
Résumé
Quantitative systems modeling aims to integrate knowledge in different research areas with models describing biological mechanisms and dynamics to gain a better understanding of complex clinical syndromes. Heart failure (HF) is a chronic complex cardiac disease that results from structural or functional disorders impairing the ability of the ventricle to fill with or eject blood. Highly interactive and dynamic changes in mechanical, structural, neurohumoral, metabolic, and electrophysiological properties collectively predispose the failing heart to cardiac arrhythmias, which are responsible for about a half of HF deaths. Multiscale cardiac modeling and simulation integrate structural and functional data from HF experimental models and patients to improve our mechanistic understanding of this complex arrhythmia syndrome. In particular, they allow investigating how disease-induced remodeling alters the coupling of electrophysiology, Ca
Identifiants
pubmed: 30015404
doi: 10.1002/wsbm.1434
pmc: PMC6336536
mid: NIHMS978415
doi:
Substances chimiques
Reactive Oxygen Species
0
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1434Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL138160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL138160
Pays : United States
Organisme : NIH HHS
ID : OT2 OD026580
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL131517
Pays : United States
Organisme : NIH HHS
ID : 1OT2OD023848-01
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131517
Pays : United States
Organisme : NIH HHS
ID : OT2 OD023848
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99HL138160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL141214
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 15SDG24910015
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141214
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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