Functional and structural plasticity following action observation training in multiple sclerosis.
Adult
Aged
Brain
/ diagnostic imaging
Case-Control Studies
Female
Frontal Lobe
/ diagnostic imaging
Functional Neuroimaging
Gray Matter
/ diagnostic imaging
Hand
/ physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis
/ diagnostic imaging
Neuronal Plasticity
Observation
Organ Size
Temporal Lobe
/ diagnostic imaging
Upper Extremity
/ physiopathology
White Matter
/ diagnostic imaging
Multiple sclerosis
action observation
hand motor impairment
plasticity
training
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
8
8
2018
medline:
23
6
2020
entrez:
8
8
2018
Statut:
ppublish
Résumé
Hand motor deficits contribute to multiple sclerosis (MS)-related disability. Action observation training (AOT) is promising to improve upper limb function in neurologic patients. In this preliminary study, we investigated AOT effects on dominant-hand motor performance in MS patients with upper limb motor impairment and performed an explorative analysis of their anatomical and functional magnetic resonance imaging (MRI) substrates. In total, 46 healthy controls (HC) and 41 MS patients with dominant-hand motor impairment were randomized to AOT (HC-AOT = 23; MS-AOT = 20; watching daily-life action videos and execution) or control-training (HC-Control = 23; MS-Control = 21; watching landscapes videos and execution). Behavioral, structural, and functional (at rest and during object manipulation) MRI scans were acquired before and after a 2-week training. After training, MS groups improved in right upper limb functions, mainly in AOT group ( The 10-day AOT promotes clinical improvements in MS patients through structural and functional modifications of the action observation matching system.
Sections du résumé
BACKGROUND
Hand motor deficits contribute to multiple sclerosis (MS)-related disability. Action observation training (AOT) is promising to improve upper limb function in neurologic patients.
OBJECTIVES
In this preliminary study, we investigated AOT effects on dominant-hand motor performance in MS patients with upper limb motor impairment and performed an explorative analysis of their anatomical and functional magnetic resonance imaging (MRI) substrates.
METHODS
In total, 46 healthy controls (HC) and 41 MS patients with dominant-hand motor impairment were randomized to AOT (HC-AOT = 23; MS-AOT = 20; watching daily-life action videos and execution) or control-training (HC-Control = 23; MS-Control = 21; watching landscapes videos and execution). Behavioral, structural, and functional (at rest and during object manipulation) MRI scans were acquired before and after a 2-week training.
RESULTS
After training, MS groups improved in right upper limb functions, mainly in AOT group (
CONCLUSION
The 10-day AOT promotes clinical improvements in MS patients through structural and functional modifications of the action observation matching system.
Identifiants
pubmed: 30084706
doi: 10.1177/1352458518792771
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM