Fatal Anaphylaxis to Atracurium: A Case Report.


Journal

A&A practice
ISSN: 2575-3126
Titre abrégé: A A Pract
Pays: United States
ID NLM: 101714112

Informations de publication

Date de publication:
01 Mar 2019
Historique:
pubmed: 22 8 2018
medline: 14 6 2019
entrez: 22 8 2018
Statut: ppublish

Résumé

A 52-year-old patient was scheduled for a cystoscopy. Anesthesia was induced by intravenous injection of fentanyl and propofol. After administration of atracurium, he became bradycardic and suffered a cardiac arrest. Despite prolonged cardiopulmonary resuscitation, the patient could not be revived. Electrolytes and hemoglobin levels were normal, and a transthoracic echocardiogram showed no signs of pericardial effusions or of any left ventricular contraction. The postmortem found no pathology. However, mast cell tryptase was raised significantly, indicating fatal anaphylaxis. Having presented no classic clinical signs, this case is a reminder that rapid cardiovascular collapse can be the sole clinical feature of anaphylaxis.

Identifiants

pubmed: 30130281
doi: 10.1213/XAA.0000000000000866
pii: 02054229-201903010-00004
doi:

Substances chimiques

Neuromuscular Nondepolarizing Agents 0
Atracurium 2GQ1IRY63P

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

145-146

Références

Hepner DL, Castells MC. Anaphylaxis during the perioperative period. Anesth Analg. 2003;97:1381–1395.
Laxenaire MC, Mertes PM, Benabes B, et al.; Groupe d’Etudes des Réactions Anaphylactoïdes Peranesthésiques. Anaphylaxis during anaesthesia. Results of a two-year survey in France. Br J Anaesth. 2001;87:549–558.
Harper NJ, Dixon T, Dugué P, et al.; Working Party of the Association of Anaesthetists of Great Britain and Ireland. Suspected anaphylactic reactions associated with anaesthesia. Anaesthesia. 2009;64:199–211.
Rose MA, Green SL, Crilly HM, Kolawole H. Perioperative anaphylaxis grading system: ‘making the grade.’ Br J Anaesth. 2016;117:551–553.
Monsieurs KG, Nolan JP, Bossaert LL, et al.; ERC Guidelines 2015 Writing Group. European Resuscitation Council Guidelines for Resuscitation 2015: Section 1. Executive summary. Resuscitation. 2015;95:1–80.
Fisher MM. Clinical observations on the pathophysiology and treatment of anaphylactic cardiovascular collapse. Anaesth Intensive Care. 1988;14:17–21.
Triggiani M, Patella V, Staiano RI, Granata F, Marone G. Allergy and the cardiovascular system. Clin Exp Immunol. 2008;153(suppl 1):7–11.
Jenson RD, Latham LB, Vitalpur GV, Dierdorf SF. Immunoglobulin e-mediated anaphylaxis on the tenth exposure to cisatracurium in a 4-year-old child. A A Case Rep. 2013;1:49–51.
Reddy JI, Cooke PJ, van Schalkwyk JM, Hannam JA, Fitzharris P, Mitchell SJ. Anaphylaxis is more common with rocuronium and succinylcholine than with atracurium. Anesthesiology. 2015;122:39–45.
Dewachter P, Mouton-Faivre C. Anaphylaxis incidence with rocuronium, succinylcholine, and atracurium: how risk communication can influence behaviour. Anesthesiology. 2015;123:718–736.

Auteurs

Jan Schumacher (J)

From the Department of Anaesthetics, Guy's and St. Thomas' National Health Service Foundation Trust, London, United Kingdom.

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Classifications MeSH