Autoregulation of bacterial gene expression: lessons from the MazEF toxin-antitoxin system.
Autoregulation
Feedback
Gene expression
MazF
Phenotypic heterogeneity
Toxin–antitoxin system
Journal
Current genetics
ISSN: 1432-0983
Titre abrégé: Curr Genet
Pays: United States
ID NLM: 8004904
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
20
07
2018
accepted:
14
08
2018
revised:
13
08
2018
pubmed:
23
8
2018
medline:
28
5
2019
entrez:
23
8
2018
Statut:
ppublish
Résumé
Autoregulation is the direct modulation of gene expression by the product of the corresponding gene. Autoregulation of bacterial gene expression has been mostly studied at the transcriptional level, when a protein acts as the cognate transcriptional repressor. A recent study investigating dynamics of the bacterial toxin-antitoxin MazEF system has shown how autoregulation at both the transcriptional and post-transcriptional levels affects the heterogeneity of Escherichia coli populations. Toxin-antitoxin systems hold a crucial but still elusive part in bacterial response to stress. This perspective highlights how these modules can also serve as a great model system for investigating basic concepts in gene regulation. However, as the genomic background and environmental conditions substantially influence toxin activation, it is important to study (auto)regulation of toxin-antitoxin systems in well-defined setups as well as in conditions that resemble the environmental niche.
Identifiants
pubmed: 30132188
doi: 10.1007/s00294-018-0879-8
pii: 10.1007/s00294-018-0879-8
pmc: PMC6343021
doi:
Substances chimiques
Bacterial Proteins
0
Bacterial Toxins
0
DNA-Binding Proteins
0
Escherichia coli Proteins
0
MazE protein, E coli
0
MazF protein, E coli
0
Endoribonucleases
EC 3.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-138Subventions
Organisme : FP7 PEOPLE
ID : ISTFELLOW
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