Duodenal and Rectal Mucosa Inflammation in Patients With Non-celiac Wheat Sensitivity.
Adult
Biopsy
Colon
/ pathology
Duodenitis
/ etiology
Duodenum
/ pathology
Eosinophils
/ pathology
Female
Histocytochemistry
Humans
Immunohistochemistry
Intestinal Mucosa
/ pathology
Italy
Male
Middle Aged
Mucositis
/ etiology
Proctitis
/ etiology
Prospective Studies
Rectum
/ pathology
Tertiary Care Centers
Wheat Hypersensitivity
/ pathology
Bread
Food Allergy
Histology
Irritable Bowel Syndrome
Nonceliac Wheat Sensitivity
Journal
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
ISSN: 1542-7714
Titre abrégé: Clin Gastroenterol Hepatol
Pays: United States
ID NLM: 101160775
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
09
02
2018
revised:
07
08
2018
accepted:
09
08
2018
pubmed:
24
8
2018
medline:
3
7
2020
entrez:
24
8
2018
Statut:
ppublish
Résumé
Studies of non-celiac gluten or wheat sensitivity (NCGWS) have increased but there are no biomarkers of this disorder. We aimed to evaluate histologic features of colon and rectal tissues from patients with NCGWS. We performed a prospective study of 78 patients (66 female; mean age, 36.4 years) diagnosed with NCGWS by double-blind wheat challenge at 2 tertiary care centers in Italy, from January 2015 through September 2016. Data were also collected from 55 patients wither either celiac disease or self-reported NCGWS but negative results from the wheat-challenge test (non-NCGWS controls). Duodenal and rectal biopsies were collected and analyzed by immunohistochemistry to quantify intra-epithelial CD3 Duodenal tissues from patients with NCGWS had significantly higher numbers of intra-epithelial CD3 We identified markers of inflammation, including increased numbers of eosinophils, in duodenal and rectal mucosa from patients with NCGWS. NCGWS might therefore involve inflammation of the entire intestinal tract. Eosinophils could serve as a biomarker for NCGWS and be involved in its pathogenesis. Clinicaltrials.gov: NCT01762579.
Sections du résumé
BACKGROUND & AIMS
Studies of non-celiac gluten or wheat sensitivity (NCGWS) have increased but there are no biomarkers of this disorder. We aimed to evaluate histologic features of colon and rectal tissues from patients with NCGWS.
METHODS
We performed a prospective study of 78 patients (66 female; mean age, 36.4 years) diagnosed with NCGWS by double-blind wheat challenge at 2 tertiary care centers in Italy, from January 2015 through September 2016. Data were also collected from 55 patients wither either celiac disease or self-reported NCGWS but negative results from the wheat-challenge test (non-NCGWS controls). Duodenal and rectal biopsies were collected and analyzed by immunohistochemistry to quantify intra-epithelial CD3
RESULTS
Duodenal tissues from patients with NCGWS had significantly higher numbers of intra-epithelial CD3
CONCLUSIONS
We identified markers of inflammation, including increased numbers of eosinophils, in duodenal and rectal mucosa from patients with NCGWS. NCGWS might therefore involve inflammation of the entire intestinal tract. Eosinophils could serve as a biomarker for NCGWS and be involved in its pathogenesis. Clinicaltrials.gov: NCT01762579.
Identifiants
pubmed: 30138736
pii: S1542-3565(18)30881-4
doi: 10.1016/j.cgh.2018.08.043
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT01762579']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
682-690.e3Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.