High prevalence and diversity of hepatitis B and hepatitis delta virus in Gabon.
Adolescent
Adult
Aged
Aged, 80 and over
Cross-Sectional Studies
Female
Gabon
/ epidemiology
Genetic Variation
Genotype
Hepatitis Antibodies
/ blood
Hepatitis B
/ epidemiology
Hepatitis B virus
/ genetics
Hepatitis D
/ epidemiology
Hepatitis Delta Virus
/ classification
Humans
Male
Middle Aged
Phylogeny
Prevalence
RNA, Viral
/ genetics
Risk Factors
Sequence Analysis, DNA
Seroepidemiologic Studies
Young Adult
Gabon
genotype
hepatitis B virus
hepatitis D virus
seroprevalence
Journal
Journal of viral hepatitis
ISSN: 1365-2893
Titre abrégé: J Viral Hepat
Pays: England
ID NLM: 9435672
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
18
04
2018
revised:
28
06
2018
accepted:
23
07
2018
pubmed:
25
8
2018
medline:
27
6
2020
entrez:
25
8
2018
Statut:
ppublish
Résumé
Although central Africa is classified as having a high endemicity of hepatitis B virus (HBV) and hepatitis D virus (HDV) infection, there is paucity of prevalence studies. For the first time on a country-wide level in Central Africa, we show in Gabon an overall 7.4% prevalence of Hepatitis B surface antigen (HBsAg) and that more than 25% of the HBsAg-positive population are infected by HDV. Although HBV prevalence did not differ significantly between provinces, there is a north-south split in the distribution of HDV seroprevalence, with the highest rates (>66.0%) correlating with the presence of specific ethnic groups in the northeastern provinces. Genotyping revealed high genetic diversity of the HBV and HDV strains circulating in Gabon, including many restricted to this region of the globe. This work confirmed that high exposure to HBV and HDV infection reported in selected regions of Gabon holds true across the whole country.
Substances chimiques
Hepatitis Antibodies
0
RNA, Viral
0
Banques de données
GENBANK
['MH172021', 'MH172151', 'MH363783', 'MH363805']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
170-182Informations de copyright
© 2018 John Wiley & Sons Ltd.