Cabergoline treatment in prolactinoma: Amelioration in obstructive and central sleep apneas.
Adult
Brain
/ diagnostic imaging
Cabergoline
/ therapeutic use
Continuous Positive Airway Pressure
/ adverse effects
Disorders of Excessive Somnolence
/ etiology
Dopamine Agonists
/ therapeutic use
Humans
Magnetic Resonance Imaging
Male
Pituitary Neoplasms
/ diagnostic imaging
Polysomnography
/ methods
Prolactinoma
/ diagnostic imaging
Sleep Apnea, Obstructive
/ diagnosis
Snoring
/ etiology
Treatment Outcome
Cabergoline
central sleep apnea
obstructive sleep apnea
pituitary neoplasms
Journal
Journal of postgraduate medicine
ISSN: 0972-2823
Titre abrégé: J Postgrad Med
Pays: India
ID NLM: 2985196R
Informations de publication
Date de publication:
Historique:
pubmed:
28
8
2018
medline:
22
5
2020
entrez:
28
8
2018
Statut:
ppublish
Résumé
A 44-year-old male patient was admitted to the otolaryngology department with a history of progressive snoring, excessive daytime sleepiness, and reduced libido for the last 6 months. Polysomnography demonstrated the presence of moderate obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) of 24.6 events/h, consisting of 77 obstructive and 59 central apneas. The marked number of central apneas in the sleep study and urologic complaints prompted the performance of brain magnetic resonance imaging (MRI), which indicated a pituitary macroadenoma (prolactinoma). Three months after treatment with cabergoline, a control MRI showed a significant reduction in the size of the macroadenoma. The AHI was also significantly decreased (to 11.6 events/h), as were the numbers of obstructive and central apneas. The patient's complaints regarding libido were also regressed. During this treatment period, CPAP therapy has not been tolerated by the patient. Cabergoline treatment reduced the severity of both obstructive and central sleep apneas in this patient.
Identifiants
pubmed: 30147082
pii: 239677
doi: 10.4103/jpgm.JPGM_113_18
pmc: PMC6380128
doi:
Substances chimiques
Dopamine Agonists
0
Cabergoline
LL60K9J05T
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-49Déclaration de conflit d'intérêts
None
Références
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pubmed: 27092695
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pubmed: 27660510