Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity.
Chimpanzee
MHC
Nonhuman primates
Journal
Immunogenetics
ISSN: 1432-1211
Titre abrégé: Immunogenetics
Pays: United States
ID NLM: 0420404
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
26
06
2018
accepted:
22
08
2018
pubmed:
31
8
2018
medline:
6
7
2019
entrez:
31
8
2018
Statut:
ppublish
Résumé
Chimpanzees have been used for some time as an animal model in research on immune-related diseases in humans. The major histocompatibility complex (MHC) region of the chimpanzee has also been the subject of studies in which the attention was mainly on the class I genes. Although full-length sequence information is available on the DRB region genes, such detailed information is lacking for the other class II genes and, if present, is based mainly on exon 2 sequences. In the present study, full-length sequencing was performed on DQ, DP, and DRA genes in a cohort of 67 pedigreed animals, thereby allowing a thorough analysis of the MHC class II repertoire. The results demonstrate that the number of MHC class II lineages and alleles is relatively low, whereas haplotype diversity (combination of genes/alleles on a chromosome) seems to have been maximised by crossing-over processes.
Identifiants
pubmed: 30159708
doi: 10.1007/s00251-018-1080-4
pii: 10.1007/s00251-018-1080-4
doi:
Substances chimiques
HLA-DP Antigens
0
HLA-DQ Antigens
0
HLA-DR Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-23Commentaires et corrections
Type : ErratumIn
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