TCR αβ+/CD19+ cell depletion in haploidentical hematopoietic allogeneic stem cell transplantation: a review of current data.
Antigens, CD19
/ metabolism
B-Lymphocytes
/ immunology
Graft Rejection
/ immunology
Graft Survival
Graft vs Host Disease
/ etiology
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Immune Reconstitution
Lymphocyte Depletion
/ methods
Mortality
Opportunistic Infections
/ etiology
Receptors, Antigen, T-Cell, alpha-beta
/ metabolism
Transplantation, Haploidentical
/ adverse effects
Transplantation, Homologous
Treatment Outcome
Graft-versus-host disease
TCR αβ+/CD19+ depletion
clinical results
graft rejection
infectious complications
Journal
Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
7
9
2018
medline:
1
5
2020
entrez:
7
9
2018
Statut:
ppublish
Résumé
Allogeneic hematopoietic stem cell transplantation is a curative option for patients with a variety of diseases. Transplantation from a related haploidentical donor is being increasingly utilized for patients who lack an available human leukocyte antigen matched related or unrelated donor. One of the strategies used for haploidentical transplants involves selective depletion of T cells expressing the αβ T cell receptor and CD19+ B cells prior to transplant. This allows for the removal of cells responsible for graft-versus-host disease and post-transplant lymphoproliferative disorder but maintains hematopoietic progenitor and stem cells for engraftment (CD34+ cells), as well as cells to elicit graft-versus-tumor effect and provide anti-infective activity (such as gamma-delta T cells and natural killer cells). The aim of this review article is to present and discuss the data available to date from studies utilizing this method of transplantation.
Identifiants
pubmed: 30187806
doi: 10.1080/10428194.2018.1485905
pmc: PMC6764418
mid: NIHMS1051506
doi:
Substances chimiques
Antigens, CD19
0
Receptors, Antigen, T-Cell, alpha-beta
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
598-609Subventions
Organisme : NCI NIH HHS
ID : P30 CA014520
Pays : United States
Références
Transplantation. 2008 Feb 15;85(3):386-90
pubmed: 18322430
J Hematother. 1999 Apr;8(2):209-18
pubmed: 10349915
Blood. 2007 Jul 1;110(1):433-40
pubmed: 17371948
J Immunother. 2005 Jan-Feb;28(1):73-8
pubmed: 15614047
Cytotherapy. 2007;9(8):746-54
pubmed: 17917892
N Engl J Med. 1998 Oct 22;339(17):1186-93
pubmed: 9780338
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
Hematology. 2017 Apr;22(3):136-144
pubmed: 27724812
Blood. 1999 Jul 1;94(1):333-9
pubmed: 10381530
Bone Marrow Transplant. 1998 May;21(10):987-93
pubmed: 9632271
J Clin Invest. 2003 Dec;112(12):1862-70
pubmed: 14679181
J Immunol. 2004 Jan 1;172(1):644-50
pubmed: 14688377
Blood. 2009 Mar 26;113(13):3119-29
pubmed: 18945967
Ann N Y Acad Sci. 2007 Jun;1106:279-89
pubmed: 17442774
Br J Haematol. 2009 Jun;145(6):816-24
pubmed: 19344418
Exp Hematol. 1999 May;27(5):860-7
pubmed: 10340402
J Hematother. 1996 Oct;5(5):503-9
pubmed: 8938522
Bone Marrow Transplant. 2016 May;51(5):668-74
pubmed: 26808573
Blood. 2017 Aug 3;130(5):677-685
pubmed: 28588018
Bone Marrow Transplant. 2007 Jun;39(12):751-7
pubmed: 17450185
Cytotherapy. 2013 Oct;15(10):1253-8
pubmed: 23993299
Blood. 2006 Feb 1;107(3):1230-2
pubmed: 16239436
Blood. 2015 Apr 9;125(15):2349-58
pubmed: 25612623
Blood. 2014 Jul 31;124(5):822-6
pubmed: 24869942
Biol Blood Marrow Transplant. 2005 Mar;11(3):161-8
pubmed: 15744234
Transplantation. 2001 Dec 27;72(12):1907-14
pubmed: 11773887
N Engl J Med. 2014 Jul 24;371(4):339-48
pubmed: 25054717
Biol Blood Marrow Transplant. 2016 Nov;22(11):2056-2064
pubmed: 27519279
Biol Blood Marrow Transplant. 2017 Mar;23(3):483-490
pubmed: 28039080
Oncoimmunology. 2016 Sep 27;6(2):e1216291
pubmed: 28344861
J Clin Oncol. 2005 May 20;23(15):3447-54
pubmed: 15753458
Blood. 2012 Jun 21;119(25):6145-54
pubmed: 22563089
Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S6-10
pubmed: 26039210
Blood Cells Mol Dis. 2008 Jan-Feb;40(1):13-9
pubmed: 17869547
Curr Opin Hematol. 2017 Nov;24(6):489-495
pubmed: 28817402