Evaluation of a PET Radioligand to Image
Acetamides
/ pharmacokinetics
Animals
Biological Transport
Brain
/ diagnostic imaging
Image Processing, Computer-Assisted
Kinetics
Ligands
Macaca mulatta
Mice
Mice, Knockout
Piperidines
/ pharmacokinetics
Positron-Emission Tomography
/ methods
Radiometry
Thiazoles
/ pharmacokinetics
Tissue Distribution
beta-N-Acetylhexosaminidases
/ metabolism
Alzheimer disease
O-GlcNAcase
PET
tau
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
18
04
2018
accepted:
09
07
2018
pubmed:
15
9
2018
medline:
5
11
2019
entrez:
15
9
2018
Statut:
ppublish
Résumé
Accumulation of hyperphosphorylated tau, a microtubule-associated protein, plays an important role in the progression of Alzheimer disease. Animal studies suggest that one strategy for treating Alzheimer disease and related tauopathies may be inhibition of
Identifiants
pubmed: 30213846
pii: jnumed.118.213231
doi: 10.2967/jnumed.118.213231
pmc: PMC6354227
doi:
Substances chimiques
Acetamides
0
Ligands
0
Piperidines
0
Thiazoles
0
lsn3316612
0
hexosaminidase C
EC 3.2.1.50
beta-N-Acetylhexosaminidases
EC 3.2.1.52
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
129-134Informations de copyright
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.
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